Cinuperone
Cinuperone is a multi-target competitive receptor ligand and σ receptor antagonist that acts on Dopamine D1, σ, Dopamine D1, and 5-HT2 receptors. Cinuperone shows significantly higher affinity for σ receptors than for Dopamine D1 receptors, and only exhibits moderate binding activity for dopamine D2 receptors. Cinuperone can be used in the research of central nervous system diseases.
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- CAS. Nr.: 82117-51-9
- Formel: C23H24FN3O
- Molecular Weight:377.46
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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D2 Receptor 75 nM (IC50) |
D1 Receptor 6200 nM (IC50) |
5-HT2 Receptor 240 nM (IC50) |
Cinuperone potently inhibits [3H]-spiperone binding to dopamine2 receptors in rat striatal membranes with an IC50 of 76 nM[2].
Cinuperone weakly inhibits [3H]-SCH 23390 binding to dopamine1 receptors in rat striatal membranes with an IC50 of 6200 nM[2].
Cinuperone potently inhibits [3H]-haloperidol binding to σ receptors in rat cerebellar membranes with an IC50 of 54 nM[2].
Cinuperone moderately inhibits [3H]-ketanserin binding to 5-HT2 receptors in rat frontal cortex membranes with an IC50 of 240 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Cinuperone (10 μmol/kg; administered 30 minutes prior to apomorphine) antagonizes apomorphine-induced climbing in male albino mice with an ED50 of 10 μmol/kg[2].
Cinuperone (15 μmol/kg; administered 30 minutes prior to apomorphine) antagonizes apomorphine-induced yawning in male albino rats with an ED50 of 15 μmol/kg[2].
Cinuperone (0.97 μmol/kg; i.p.; administered 30 minutes prior to quipazine) antagonizes quipazine-induced head twitches in male albino rats with an ED50 of 0.97 μmol/kg[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 82117-51-9
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Molecular Weight 377.46
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Formel C23H24FN3O
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SMILES
O=C(C1=CC=C(F)C=C1)CCCN2CCN(C=3N=CC4=CC=CC=C4C3)CC2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Cinuperone Related Classifications
HY-W754019 Related Classifications
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