DCPLA-ME
Based on 2 publication(s) in Google Scholar
DCPLA-ME, the methyl ester form of DCPLA, is a potent PKCε activator for use in the treatment of neurodegenerative diseases.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 98.0%
- CAS. Nr.: 56687-67-3
- Formel: C21H38O2
- Molecular Weight:322.53
-
Speicherung:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
-
HY-P0154
Epsilon-V1-2PKCε Inhibitor -
HY-13689
Go 6983PKC Inhibitor -
HY-10195
RuboxistaurinPKCβ Inhibitor -
HY-13772
ValrubicinAntibiotic -
HY-10195B
Ruboxistaurin hydrochloridePKCβ Inhibitor -
HY-13867
Bisindolylmaleimide IPKC Inhibitor -
HY-18965
TAS-301PKC Inhibitor -
HY-101569
DarovasertibPKC Inhibitor -
HY-N0699
DaphnoretinPKC Activator -
HY-117800
BJE6-106PKCδ Inhibitor -
HY-12307
(-)-Indolactam VPKC Activator -
HY-13866
Ro 31-8220 mesylatePCK Inhibitor
Publications Citing Use of MedChemExpress (MCE) DCPLA-ME
More
Biologische Aktivität
Beschreibung
IC50 & Target
|
PKCε |
Chemical Information
-
CAS. Nr. 56687-67-3
-
Appearance Liquid (Density: 0.938±0.06 g/cm3)
-
Molecular Weight 322.53
-
Formel C21H38O2
-
Color Colorless to light yellow
-
SMILES
O=C(OC)CCCCCCCC1C(CC2C(CCCCC)C2)C1
-
Synonyms
DCPLA methyl ester
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Front Aging Neurosci
PKCε Activation Restores Loss of PKCε, Manganese Superoxide Dismutase, Vascular Endothelial Growth Factor, and Microvessels in Aged and Alzheimer's Disease Hippocampus. [Abstract]2022 Mar 1:14:836634. PMID: 35299945 -
bioRxiv
Palmitoylated importin α recruits PKCε to the plasma membrane to drive breast cancer cell motility. [Abstract]2026 Jun 1:2026.05.28.728515. PMID: 42282530
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 15.62 mg/mL (48.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.56 mg/mL (4.84 mM); Clear solution
This protocol yields a clear solution of ≥ 1.56 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (15.6 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
-
Data Sheet (266 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1005 mL | 15.5024 mL | 31.0049 mL | 77.5122 mL |
| 5 mM | 0.6201 mL | 3.1005 mL | 6.2010 mL | 15.5024 mL | |
| 10 mM | 0.3100 mL | 1.5502 mL | 3.1005 mL | 7.7512 mL | |
| 15 mM | 0.2067 mL | 1.0335 mL | 2.0670 mL | 5.1675 mL | |
| 20 mM | 0.1550 mL | 0.7751 mL | 1.5502 mL | 3.8756 mL | |
| 25 mM | 0.1240 mL | 0.6201 mL | 1.2402 mL | 3.1005 mL | |
| 30 mM | 0.1033 mL | 0.5167 mL | 1.0335 mL | 2.5837 mL | |
| 40 mM | 0.0775 mL | 0.3876 mL | 0.7751 mL | 1.9378 mL |
DCPLA-ME Related Classifications
HY-108599A Related Classifications
Powered by Bioz