Harmalan
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Harmalan is a tryptamine binding site stimulant and an imidazoline binding site ligand. Harmalan can be isolated from the leaves of Flindersia laevicarpa. Harmalan elevates 5-HT (HY-B1473A) levels and reduces 5-HIAA levels in the cerebral cortex. Harmalan increases spontaneous motor activity, induces clonic convulsions, produces anxiogenic effects, and elicits head weaving, hindlimb abduction, trunk curvature, piloerection, resting tremor, ataxia, forelimb abduction with increased muscle tone, and occasional alternating forepaw treading behaviors.
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- Reinheit: 98.45%
- CAS. Nr.: 525-41-7
- Formel: C12H12N2
- Molecular Weight:184.24
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Speicherung:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| FM3A | EC50 |
1.0 x 10-5 M
Compound: 6
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In vitro cytotoxic activity tested in mouse mammary tumor FM3A cells
In vitro cytotoxic activity tested in mouse mammary tumor FM3A cells
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[PMID: 15026051] |
| H9 | EC50 |
32 μM
Compound: 21
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Antiviral activity against HIV1 in human H9 cells assessed as inhibition of viral replication
Antiviral activity against HIV1 in human H9 cells assessed as inhibition of viral replication
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[PMID: 11473435] |
| H9 | IC50 |
110.3 μM
Compound: 21
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Cytotoxicity against human H9 cells
Cytotoxicity against human H9 cells
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[PMID: 11473435] |
Harmalan exhibits low affinity for benzodiazepine binding sites in rat brain cell membranes, with an IC50 of 419 μM[1].
Harmalan binds to the 5-HT2 receptor sites on the cell membrane of the rat prefrontal cortex, with an IC50 value of 1.92 μM[1].
Harmalan exhibits high affinity for tryptamine binding sites in rat cerebral cortex cell membranes, with an IC50 of 0.038 μM[1].
Harmalan potently binds to the I-1 imidazoline binding site on rat renal cell membranes, with an IC50 of 46 nM[3].
Harmalan (40 min) potently binds to the I-2 imidazoline binding sites in rat whole brain cell membranes, with a Ki value of 148 nM[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Harmalan (1-40 mg/kg; i.v.) dose-dependently induces clonic convulsions in female Wistar rats, an effect antagonized by benzodiazepine agonist but not benzodiazepine site blockers, and modulated by serotonin/tryptamine receptor agents[1].
Harmalan (34 µmol/kg; i.v.) increases cerebral cortex 5-HT concentrations and decreases 5-HIAA concentrations in female Wistar rats, with additive effects when combined with monoamine oxidase inhibitor and indolealkylamine[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (female, 180-220 g)[1]
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Dosage:3.125 mg/kg; 6.25 mg/kg; 9.375 mg/kg; 10 mg/kg; 12.5 mg/kg
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Administration:i.v.
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Result:Caused lateral head weaving, hind limb abduction, back bending, coat ruffling, and resting torso tremor in 8/10 rats at 3.125 mg/kg.
Induced head and torso resting tremor lasting 2-3 hours, ataxia, forelimb abduction, increased extensor muscle tone, and occasional reciprocal forepaw treading in all rats, plus clonic convulsions followed by postictal relaxation in 3/10 rats at 6.25 mg/kg.
Triggered seizure trains lasting up to 15 minutes post-injection in 7/10 rats at 9.375 mg/kg.
Produced clonic convulsions in 9/10 rats at 10 mg/kg.
Induced marked excitation with generalized convulsions and jumping up to 0.5 m in all rats at 12.5 mg/kg.
Chemical Information
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CAS. Nr. 525-41-7
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Appearance Solid
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Molecular Weight 184.24
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Formel C12H12N2
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Color Yellow to brown
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SMILES
CC1=NCCC2=C1NC3=CC=CC=C23
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Lösungsmittel & Löslichkeit
DMSO : 50 mg/mL (271.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (279 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.4277 mL | 27.1385 mL | 54.2770 mL | 135.6926 mL |
| 5 mM | 1.0855 mL | 5.4277 mL | 10.8554 mL | 27.1385 mL | |
| 10 mM | 0.5428 mL | 2.7139 mL | 5.4277 mL | 13.5693 mL | |
| 15 mM | 0.3618 mL | 1.8092 mL | 3.6185 mL | 9.0462 mL | |
| 20 mM | 0.2714 mL | 1.3569 mL | 2.7139 mL | 6.7846 mL | |
| 25 mM | 0.2171 mL | 1.0855 mL | 2.1711 mL | 5.4277 mL | |
| 30 mM | 0.1809 mL | 0.9046 mL | 1.8092 mL | 4.5231 mL | |
| 40 mM | 0.1357 mL | 0.6785 mL | 1.3569 mL | 3.3923 mL | |
| 50 mM | 0.1086 mL | 0.5428 mL | 1.0855 mL | 2.7139 mL | |
| 60 mM | 0.0905 mL | 0.4523 mL | 0.9046 mL | 2.2615 mL | |
| 80 mM | 0.0678 mL | 0.3392 mL | 0.6785 mL | 1.6962 mL | |
| 100 mM | 0.0543 mL | 0.2714 mL | 0.5428 mL | 1.3569 mL |
Harmalan Related Classifications
HY-W194842 Related Classifications
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