HLCL-61
Based on 2 publication(s) in Google Scholar
HLCL-61 is a first-in-class small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 586395-74-6
- Formel: C23H24N2O
- Molecular Weight:344.45
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Biologische Aktivität
Protein arginine methyltransferase 5[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MV4-11 | IC50 |
7.21 μM
Compound: 98; HLCL-61
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Inhibition of cell growth in human MV4-11 cells measured after 48 hrs by MTS assay
Inhibition of cell growth in human MV4-11 cells measured after 48 hrs by MTS assay
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[PMID: 38359536] |
| THP-1 | IC50 |
3.98 μM
Compound: 98; HLCL-61
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Inhibition of cell growth in human THP-1 cells measured after 48 hrs by MTS assay
Inhibition of cell growth in human THP-1 cells measured after 48 hrs by MTS assay
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[PMID: 38359536] |
HLCL-61 (1-100 μM; 24-72 hours) reduces cells growth at dose-dependent manner with IC50s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively[1].
HLCL-61 shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples, starting at 12 h post-treatment and persisting after 48 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MV4-11 cells, THP-1 cells, FLT3-WT blast (primary blasts from patients), FLT3-ITD blast (primary blasts from patients)
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Concentration:1, 5, 10, 25, 50, 100 μM
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Incubation Time:24, 48, 72 hours
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Result:Dose-dependent reduction in cell viability with IC50s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively.
Chemical Information
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CAS. Nr. 586395-74-6
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Molecular Weight 344.45
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Formel C23H24N2O
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SMILES
COC1=CC=CC=C1CNCC2=CC3=C(C=C2)N(CC)C4=C3C=CC=C4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Proc Natl Acad Sci U S A
2019 Feb 19;116(8):2961-2966. PMID: 30718431 -
J Virol
PRMT5 Facilitates Infectious Bursal Disease Virus Replication through Arginine Methylation of VP1. [Abstract]2023 Mar 30;97(3):e0163722. PMID: 36786602
HLCL-61 purchased from MedChemExpress. Usage Cited in: J Virol. 2023 Mar 30;97(3):e0163722. [Abstract]
HLCL-61 hydrochloride (4 µg/mL; 6 h) noticeably inhibits arginine methylation of VP1 in Flag-VP1-transfected DF-1 cells.
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Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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