OART
OART (Oxaliplatin-artesunate) is a ferroptosis inducer. OART significantly inhibits tumor cell proliferation. OART induces cytoplasmic and mitochondrial LPO to promote tumor ferroptosis, via destroying glutathione-mediated ferroptosis defense system and enhancing iron-dependent Fenton reaction. OART enhances tumor immunogenicity, transforming tumor environment from immunosuppressive to immunosensitive. OART has strong tumor regression in tumor-bearing mouse models. OART can be used for cancer immunotherapy research.
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- Formel: C27H42N2O13Pt+
- Molecular Weight:797.71
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
Chemical Information
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Molecular Weight 797.71
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Formel C27H42N2O13Pt+
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SMILES
[OH-][Pt+4]12([O-]C(C([O-]2)=O)=O)(OC(CCC(O[C@@H]([C@@H]([C@@]3(CC[C@H]([C@@]4(CC5)[H])C)[H])C)O[C@](O[C@]65C)([C@]34OO6)[H])=O)=O)[NH2][C@@]7([H])[C@](CCCC7)([H])[NH2]1
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Synonyms
Oxaliplatin-artesunate
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
OART Related Classifications
HY-177483 Related Classifications
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- OART
- Oxaliplatin-artesunate
- Ferroptosis
- Mitochondrial Metabolism
- Glutathione Peroxidase
- Transferrin Receptor
- MMP
- Dihydroorotate Dehydrogenase
- Cytoplasmic
- Mitochondrial
- LPO
- 4T1 cells
- B16F10 cells
- Renca cells
- HUVEC
- Glutathione
- Fenton reaction
- Tumor regression
- Cancer immunotherapy
- Tumor-bearing mouse models
- Inhibitor
- inhibitor
- inhibit