OUL245
OUL245 is a 7-Hydroxy derivative, and a selectively PARP2 inhibitor (IC50=44 nM). OUL245 also inhibits other PARP and TNKS enzymes with IC50s of 2.9-8.8 μM.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1023814-45-0
- Formel: C8H5N3OS
- Molecular Weight:191.21
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
|
PARP2 44 nM (IC50) |
PARP-1 570 nM (IC50) |
PARP3 8.8 μM (IC50) |
PARP4 6.0 μM (IC50) |
TNKS1 1.6 μM (IC50) |
TNKS2 370 μM (IC50) |
PARP10 2.9 μM (IC50) |
PARP14 6.7 μM (IC50) |
PARP15 2.0 μM (IC50) |
OUL245 (1 μM; 10-12 d) unlike other derivatives, does not save cells overexpressing PARP10 from ADP ribosylation-dependent cell death[1].
Pharmacokinetic Analysis[1]
| water solubility μg/mL | GI Papp×10-6 cm/s (RM %) | BBB Papp×10-6 cm/s (RM %) | metabolic stablity % | stab in human plasma | stab. in MeOH | stab in PBS pH 7.4 |
| 24.91 | 0.019 | 0.164 | 95.05 | >24 | >24 | >24 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 1023814-45-0
-
Molecular Weight 191.21
-
Formel C8H5N3OS
-
SMILES
C1=CC2=C(C=C1O)SC3=NN=CN23
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Powered by Bioz