TFGF-18
TFGF-18 is a GSK-3β inhibitor (IC50: 0.59 μM). TFGF-18 inhibits LPS-induced microglia activation and proinflammatory mediators release via inhibiting GSK-3β and downstream p65/NF-κB signaling. TFGF-18 inhibits neuronal apoptosis and oxidative stress, inhibits expressions of Bax, caspase3 and cleaved-caspase3 and increases the expression of Bcl-2. TFGF-18 has neuroprotection effect, inhibit neuroinflammation and attenuates cognitive impairment.
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- CAS. Nr.: 2222662-20-4
- Formel: C28H30F3NO11
- Molecular Weight:613.53
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
Chemical Information
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CAS. Nr. 2222662-20-4
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Molecular Weight 613.53
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Formel C28H30F3NO11
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SMILES
COC1=C(C(C=C(C2=CC(OC)=C(C=C2)OC)O3)=O)C3=CC(OC)=C1[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)C(N[C@@H](C)C(F)(F)F)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Xu M, et al. Anti-Neuroinflammatory Effects of a Semi-Synthetic Isoorientin-Based Glycogen Synthase Kinase-3β Inhibitor in Lipopolysaccharide-Activated Microglial Cells. ACS Chem Neurosci. 2022 Jan 5;13(1):43-52. [Content Brief]
[2]. Zhao Y, et al. Anti-oxidative stress and cognitive improvement of a semi-synthetic isoorientin-based GSK-3β inhibitor in rat pheochromocytoma cell PC12 and scopolamine-induced AD model mice via AKT/GSK-3β/Nrf2 pathway. Exp Neurol. 2024 Oct;380:114881. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
TFGF-18 Related Classifications
HY-171031 Related Classifications
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