(±)-trans-BAS-2
(±)-trans-BAS-2 is a hHDAC6 inhibitor with an IC50 value of 0.462 μM. (±)-trans-BAS-2 serves as a scaffold for the design of proteolysis-targeting chimeras (PROTACs) and induces proteasome-dependent degradation of hHDAC6 in cells. (±)-trans-BAS-2 can be used in the research of triple-negative breast cancer and multiple myeloma.
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- CAS. Nr.: 2790482-16-3
- Formel: C13H21N3O2S
- Molecular Weight:283.39
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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HDAC6 0.462 μM (IC50) |
(±)-trans-BAS-2 (compound 1) (0.462-30 μM; 1 h) potently inhibits recombinant full-length human HDAC6 with an IC50 of 0.462 μM[1].
(±)-trans-BAS-2 (10-12.68 μM; 24 h) induces dose-dependent cell death in MDA-MB-231 triple-negative breast cancer cells with an IC50 of 12.68 μM[1].
(±)-trans-BAS-2 (10-12.68 μM; 24 h) induces dose-dependent cell death in JJN3 multiple myeloma cells with an IC50 of 12.68 μM[1].
(±)-trans-BAS-2 (2 mM; 30 min) does not inhibit recombinant zebrafish HDAC6 CD2 at a concentration of 2 mM[1].
(±)-trans-BAS-2 (50 μM; 24 h) inhibits WT human HDAC6 activity in MDA-MB-231 cells, increasing acetyl-α-tubulin levels, but does not inhibit D567N mutant human HDAC6 activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 triple-negative breast cancer cells
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Concentration:12.68 μM (IC50); 10 μM
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Incubation Time:24 h
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Result:Induced dose-dependent cell death in MDA-MB-231 cells, with an IC50 of 12.68 μM for cell death.
Caused 28.72% cell death at 10 μM.
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Cell Line:JJN3 multiple myeloma cells
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Concentration:12.68 μM (IC50); 10 μM
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Incubation Time:24 h
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Result:Induced dose-dependent cell death in JJN3 cells, with an IC50 of 12.68 μM for cell death.
Caused 28.72% cell death at 10 μM.
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Cell Line:MDA-MB-231 cells transfected with WT or D567N human HDAC6-FLAG
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Concentration:50 μM
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Incubation Time:24 h
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Result:Significantly increased acetyl-α-tubulin levels in cells transfected with WT human HDAC6-FLAG (densitometry value of ~12 × 104 relative units, normalized to FLAG).
Had no effect on acetyl-α-tubulin levels in cells transfected with D567N human HDAC6-FLAG.
Chemical Information
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CAS. Nr. 2790482-16-3
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Molecular Weight 283.39
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Formel C13H21N3O2S
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SMILES
[H][C@@]12[C@](NC(SCC(N3CCOCC3)=O)=N2)([H])CCCC1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
(±)-trans-BAS-2 Related Classifications
HY-184505 Related Classifications
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