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Art. -Nr.: HY-P2012

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TRP-601

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

TRP-601 is a caspase inhibitor. TRP-601 reversed the increased expression of active caspase-2, the activation of endogenous apoptotic pathway and the up-regulation of key protein triggered by hyperoxia.

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CAS. Nr.: 1094569-02-4
Formel: C₄₀H₄₈F₂N₆O₁₁
Molecular Weight:826.84

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Please store the product under the recommended conditions in the Certificate of Analysis.

TRP-601 Chemical Structure

CAS. Nr.: 1094569-02-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (1)
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Caspase-2

Caspase 3

Bcl-2

Alle Caspase Isoform-spezifische Produkte anzeigen :

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen :

In Vivo

TRP-601 (1 mg/kg, Intraperitoneal injection, single dose) reduces hyperoxia-induced caspase activation in rats, attenuates neuronal cell death in the developing brain in rats and inhibits intrinsic apoptotic signaling^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Wistar rats ^[1]
Dosage:

1 mg/kg
Administration:

Intraperitoneal injection (i.p.)
Result:

Ameliorated the increase of caspase-3 activity and reduced protein expression of processed caspase-2 and enzymatic activity.
Significantly reduced neuronal cell death and did not influence levels of physiological apoptosis.
Decreased Apaf-1 protein expression to control levels.
Increased mRNA expression of Bcl-2.

Chemical Information

CAS. Nr. 1094569-02-4
Molecular Weight 826.84
Formel C₄₀H₄₈F₂N₆O₁₁
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Phytomedicine

The protective mechanism of Hydroxysafflor yellow A for the treatment of stroke - heart - syndrome via activating the ZBP1-NLRP3 signaling pathway. [Abstract]

2025 Sep:145:157011. PMID: 40602292

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (260 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. M Sifringer, et al. Prevention of neonatal oxygen-induced brain damage by reduction of intrinsic apoptosis. Cell Death Dis. 2012 Jan 12;3(1):e250. [Content Brief]

[2]. Sifringer M, et al. Prevention of neonatal oxygen-induced brain damage by reduction of intrinsic apoptosis [J]. Cell death & disease, 2012, 3(1): e250-e250.

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Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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TRP-601

1 Cited Publications

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Biologische Aktivität
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- IC₅₀ & Target
- In Vivo
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Publications (1)
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TRP-601

Publications Citing Use of MedChemExpress (MCE) TRP-601

Alle Caspase Isoform-spezifische Produkte anzeigen

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

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TRP-601 Related Classifications

HY-P2012 Related Classifications