Cat. No.: HY-110280

MC1742

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

MC1742 is a potent HDAC inhibitor, with IC₅₀s of 0.1 μM, 0.11 μM, 0.02 μM, 0.007 μM, 0.61 μM, 0.04 μM and 0.1 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10 and HDAC11, respectively. MC1742 can increase acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells growth. MC1742 can induce growth arrest, apoptosis, and differentiation in sarcoma CSC.

For research use only. We do not sell to patients.

Purity: 98.95%
CAS No.: 1776116-74-5
Formula: C₂₁H₂₁N₃O₃S
Molecular Weight:395.47

Storage:

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

MC1742 Chemical Structure

CAS No.: 1776116-74-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

HDAC1

0.1 μM (IC₅₀)

HDAC2

0.11 μM (IC₅₀)

HDAC3

0.02 μM (IC₅₀)

HDAC6

0.007 μM (IC₅₀)

HDAC8

0.61 μM (IC₅₀)

HDAC10

0.04 μM (IC₅₀)

HDAC11

0.1 μM (IC₅₀)

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HFF	IC₅₀	3295 nM Compound: 1	Cytotoxicity against HFF Cytotoxicity against HFF	[PMID: 30366254]

In Vitro

MC1742 (compound 1) (0.5 and 2 μM; 24 hours) increases acetylation in a dose-dependent manner, observable as punctuate nuclear staining of acetyl-histone H3^[1].
MC1742 (0.5, 1 and 2 μM; 24, 48 and 72 hours) significantly induces apoptosis of all CSC cultures^[1].
MC1742 (0.025-0.5 μM; 14 days) enhances bone nodule formation in a significant dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence

Cell Line:

Sarcoma cancer stem cells^[1]
Concentration:

0.5 and 2 μM
Incubation Time:

24 hours
Result:

Increased acetylation in a dose-dependent manner, observable as punctuate nuclear staining of acetyl-histone H3.

Apoptosis Analysis

Cell Line:

Sarcoma cancer stem cells^[1]
Concentration:

0.5, 1 and 2 μM
Incubation Time:

24, 48 and 72 hours
Result:

Significantly induced apoptosis of all CSC cultures.

Cell Differentiation Assay

Cell Line:

Sarcoma cancer stem cells^[1]
Concentration:

0.025, 0.05, 0.1 and 0.5 μM
Incubation Time:

14 days
Result:

Successfully enhanced bone nodule formation in a significant dose-dependent manner.

Chemical Information

CAS No. 1776116-74-5
Appearance Solid
Molecular Weight 395.47
Formula C₂₁H₂₁N₃O₃S
Color White to off-white
SMILES

O=C1N=C(NC(C2=CC=C(C3=CC=CC=C3)C=C2)=C1)SCCCCC(NO)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Publications (1)

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Journal Impact Factor

Int J Parasitol Drugs Drug Resist

2026 May 17;31:100649.

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (505.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5286 mL

12.6432 mL

25.2864 mL

5 mM

0.5057 mL

2.5286 mL

5.0573 mL

10 mM

0.2529 mL

1.2643 mL

2.5286 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Di Pompo G, et al. Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells. J Med Chem. 2015;58(9):4073-4079. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5286 mL	12.6432 mL	25.2864 mL	63.2159 mL
	5 mM	0.5057 mL	2.5286 mL	5.0573 mL	12.6432 mL
	10 mM	0.2529 mL	1.2643 mL	2.5286 mL	6.3216 mL
	15 mM	0.1686 mL	0.8429 mL	1.6858 mL	4.2144 mL
	20 mM	0.1264 mL	0.6322 mL	1.2643 mL	3.1608 mL
	25 mM	0.1011 mL	0.5057 mL	1.0115 mL	2.5286 mL
	30 mM	0.0843 mL	0.4214 mL	0.8429 mL	2.1072 mL
	40 mM	0.0632 mL	0.3161 mL	0.6322 mL	1.5804 mL
	50 mM	0.0506 mL	0.2529 mL	0.5057 mL	1.2643 mL
	60 mM	0.0421 mL	0.2107 mL	0.4214 mL	1.0536 mL
	80 mM	0.0316 mL	0.1580 mL	0.3161 mL	0.7902 mL
	100 mM	0.0253 mL	0.1264 mL	0.2529 mL	0.6322 mL

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MC1742

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Histone Modification Research Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Liver Cancer Compound Library

Osteogenesis Compound Library

Cell Death Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Brain Cancer Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

High-Efficiency Gene Editing Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) MC1742

All HDAC Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

MC1742

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Epigenetics Compound Library

Histone Modification Research Compound Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Anti-Breast Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Liver Cancer Compound Library

Osteogenesis Compound Library

Cell Death Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Brain Cancer Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

High-Efficiency Gene Editing Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) MC1742

All HDAC Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

MC1742 Related Classifications

HY-110280 Related Classifications