Meropenem
Based on 34 publication(s) in Google Scholar
Meropenem (SM 7338) is a carbapenem antibiotic with broad-spectrum antibacterial activity. Meropenem has activity against susceptible and resistant N. gonorrhoeae (MIC value of 0.02-0.06 mg/mL), H. influenzae (MIC value of 0.03-0.12 mg/mL), and H. ducreyi (MIC value of 0.015-0.12 mg/mL).
For research use only. We do not sell to patients.
- Purity: 99.85%
- CAS No.: 96036-03-2
- Formula: C17H25N3O5S
- Molecular Weight:383.46
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Publications Citing Use of MedChemExpress (MCE) Meropenem
More- Nat Microbiol. 2023 Mar;8(3):410-423. [Abstract]
- Nat Commun. 2022 Mar 2;13(1):1116. [Abstract]
- Nano Today. 2024 Dec.
- J Exp Med. 2026 Mar 2;223(3):e20241287. [Abstract]
- Proc Natl Acad Sci U S A. 2024 Jan 16;121(3):e2314514121. [Abstract]
- Emerg Microbes Infect. 2024 Dec;13(1):2321981. [Abstract]
- Biomed Pharmacother. 2023 Dec 31:169:115856. [Abstract]
- Virulence. 2026 Dec 31;17(1):2646808. [Abstract]
- Bioorg Chem. 2025 Jun 1:159:108421. [Abstract]
- Int J Antimicrob Agents. 2025 Jun 9:107551. [Abstract]
- Spectrochim Acta A Mol Biomol Spectrosc. 2020 Apr 5;230:118066. [Abstract]
- Int J Antimicrob Agents. 2018 Aug;52(2):269-271. [Abstract]
- mLife. 2025 Apr 15;4(2):155-168. [Abstract]
- Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00414-18. [Abstract]
- FASEB J. 2026 Jan 31;40(2):e71438. [Abstract]
- BMC Microbiol. 2025 Apr 29;25(1):257. [Abstract]
- Microorganisms. 2024 Mar 13;12(3):575. [Abstract]
- iScience. 2025 Mar 28;28(5):112311. [Abstract]
- Microbiol Spectr. 2025 Oct 16:e0160325. [Abstract]
- Microbiol Spectr. 2024 Aug 6;12(8):e0397923. [Abstract]
- Open Forum Infect Dis. 2023 Jan 27;10(2):ofad038. [Abstract]
- J Antimicrob Chemother. 2026 Jun 3;81(7):dkag204. [Abstract]
- J Antimicrob Chemother. 2026 Feb 2;81(3):dkag034. [Abstract]
- J Antimicrob Chemother. 2025 Nov 5:dkaf408. [Abstract]
- J Antimicrob Chemother. 2020 Jul 1;75(7):1850-1858. [Abstract]
- J Glob Antimicrob Resist. 2025 Apr 26:S2213-7165(25)00088-8. [Abstract]
- Eur J Clin Microbiol Infect Dis. 2025 Sep 29. [Abstract]
- Infect Drug Resist. 2026 May 8;19.
- Infect Drug Resist. 2021 Jun 30;14:2499-2507. [Abstract]
- J Antibiot (Tokyo). 2026 Feb 17. [Abstract]
- Infect Genet Evol. 2025 Sep:133:105780. [Abstract]
- J Microbiol Methods. 2026 Feb 25:107441. [Abstract]
- Diagn Microbiol Infect Dis. 2026 Feb;114(2):117181. [Abstract]
- bioRxiv. 2024 May 10.
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Microbiological Assay
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Microbiological Assay
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Microbiological Assay
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Microbiological Assay
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Microbiological Assay
All Antibiotic Isoforms
More
Biological Activity
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β-lactam |
Meropenem is intrinsically stable to dehydropeptidase-1 (DHP-1) degradation and Meropenem acts by inhibiting bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBPs). Meropenem possesses broad-spectrum in vitro activity, which includes activity against many Gram-positive, Gram-negative and anaerobic bacteria; Meropenem lacks activity against Enterococcus faecium, methicillin-resistant Staphylococcus aureus and Stenotrophomonas maltophilia[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats (250-350 g) induced acute necrotizing pancreatitis[3]
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Dosage:60 mg/kg
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Administration:Intraperitoneal injection; once
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Result:Significantly reduced the incidence of pancreatic infection.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 96036-03-2
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Appearance Solid
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Molecular Weight 383.46
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Formula C17H25N3O5S
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Color Off-white to light yellow
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SMILES
O=C(C(N12)=C(S[C@@H]3CN[C@H](C(N(C)C)=O)C3)[C@H](C)[C@]2([H])[C@@H]([C@H](O)C)C1=O)O
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Synonyms
SM 7338
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Structure Classification
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Initial Source
aerobes and anaerobes
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (34)
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Journal Impact Factor
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Most Recent
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Nat Microbiol
Characterization of antibiotic resistomes by reprogrammed bacteriophage-enabled functional metagenomics in clinical strains. [Abstract]2023 Mar;8(3):410-423. PMID: 36759752 -
Nat Commun
Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China. [Abstract]2022 Mar 2;13(1):1116. PMID: 35236849
Meropenem purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Mar 2;13(1):1116. [Abstract]
Resistance rates of Escherichia coli isolates from farms in different provinces of mainland China to different classes of antibiotics, including Meropenem.
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J Exp Med
2026 Mar 2;223(3):e20241287. PMID: 41400657 -
Proc Natl Acad Sci U S A
In-patient evolution of a high-persister Escherichia coli strain with reduced in vivo antibiotic susceptibility. [Abstract]2024 Jan 16;121(3):e2314514121. PMID: 38190524 -
Emerg Microbes Infect
AMXT-1501 targets membrane phospholipids against Gram-positive and -negative multidrug-resistant bacteria. [Abstract]2024 Dec;13(1):2321981. PMID: 38422452
Meropenem purchased from MedChemExpress. Usage Cited in: Emerg Microbes Infect. 2024 Dec;13(1):2321981. [Abstract]
Antibacterial activity of AMXT-1501 against K. pneumoniae, an ESBL-producing E. coli, and carbapenem-resistant Enterobacteriaceae E. coli detected by time-killing assays; compared with meropenem or tigecycline (final concentration at 8× MIC); The dashed lines indicated the limit of detection of time-killing assays. Antibacterial activity of AMXT-1501 against abdominal infected with E. coli ECO2219 (n = 15/group); compared with TIG.
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Biomed Pharmacother
The enhancement effect of small molecule Lyb24 reveals AzoR as a novel target of polymyxin B. [Abstract]2023 Dec 31:169:115856. PMID: 37949698 -
Virulence
Antibacterial efficacy and mechanism of the novel antimicrobial peptide lachnospirin-1 against Acinetobacter baumannii. [Abstract]2026 Dec 31;17(1):2646808. PMID: 41838520 -
Bioorg Chem
Repurposing tavaborole to combat resistant bacterial infections through competitive inhibition of KPC-2 and metabolic disruption. [Abstract]2025 Jun 1:159:108421. PMID: 40179579 -
Int J Antimicrob Agents
Elucidating adaptive compensatory tigecycline resistance mechanisms of RamA, RarA and SoxS in Klebsiella pneumoniae. [Abstract]2025 Jun 9:107551. PMID: 40499596 -
Spectrochim Acta A Mol Biomol Spectrosc
Spectral signal processing approaches for selective quantification of the recently FDA approved brand-new combination of Vaborbactam and Meropenem; for conformity assessment of bulk and batch release. [Abstract]2020 Apr 5;230:118066. PMID: 31958602 -
Int J Antimicrob Agents
Activity of TP-6076 against carbapenem-resistant Acinetobacter baumannii isolates collected from inpatients in Greek hospitals. [Abstract]2018 Aug;52(2):269-271. PMID: 29559273 -
mLife
Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria. [Abstract]2025 Apr 15;4(2):155-168. PMID: 40313980
Meropenem purchased from MedChemExpress. Usage Cited in: mLife. 2025 Apr 15;4(2):155-168. [Abstract]
Treatment of wild-type BCG with the ClpP-targeting compound GDI-5755 and Ethambutol (ETH) or Meropenem (MPM) significantly reduced the minimum inhibitory concentration (MIC) of each drug.
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Antimicrob Agents Chemother
Aztreonam-Avibactam Combination Restores Susceptibility of Aztreonam in Dual-Carbapenemase-Producing Enterobacteriaceae. [Abstract]2018 Jul 27;62(8). pii: e00414-18. PMID: 29760136 -
FASEB J
Enhancing the Susceptibility of Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics Through the Use of 4-Methoxysalicyl Aldehyde. [Abstract]2026 Jan 31;40(2):e71438. PMID: 41524623 -
BMC Microbiol
Klebsiella pneumoniae under xylose pressure: the growth adaptation, antimicrobial susceptibility, global proteomics analysis and role of XylA and XylB proteins. [Abstract]2025 Apr 29;25(1):257. PMID: 40301709
Meropenem purchased from MedChemExpress. Usage Cited in: BMC Microbiol. 2025 Apr 29;25(1):257. [Abstract]
To evaluate the influence of various concentrations of xylose on the antimicrobial susceptibility of K. pneumoniae, the MIC values of K. pneumoniaetoward commonly used antibiotics, including Meropenem, Gentamicin, and Ceftriaxone, were determined after xylose exposure at various concentrations.
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Microorganisms
Antimicrobial Resistance and Genomic Characteristics of Escherichia coli Strains Isolated from the Poultry Industry in Henan Province, China. [Abstract]2024 Mar 13;12(3):575. PMID: 38543626
Meropenem purchased from MedChemExpress. Usage Cited in: Microorganisms. 2024 Mar 13;12(3):575. [Abstract]
Percentages of E. coli strains showing antimicrobial resistance to different antimicrobial agents. AMP, Ampicillin; CAZ, Ceftazidime; IPM, Imipenem; MRP, Meropenem; GEN, Gentamicin; OFX, Ofloxacin; SXT, Trimethoprim–sulfamethoxazole; TET, Tetracycline; TGC, Tigecycline; CL, Colistin; FFC, Florfenicol.
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iScience
The oxacillinase variant, OXA-1152, in Pandoraea sputorum contributes to discrepancies in carbapenem resistance. [Abstract]2025 Mar 28;28(5):112311. PMID: 40454099 -
Microbiol Spectr
The adaptive growth and mechanisms of Klebsiella pneumoniae under sucrose and glucose exposure. [Abstract]2025 Oct 16:e0160325. PMID: 41099518 -
Microbiol Spectr
Antimicrobial peptide A20L: in vitro and in vivo antibacterial and antibiofilm activity against carbapenem-resistant Klebsiella pneumoniae. [Abstract]2024 Aug 6;12(8):e0397923. PMID: 38980018 -
Open Forum Infect Dis
Trends of β-Lactamase Occurrence Among Escherichia coli and Klebsiella pneumoniae in United States Hospitals During a 5-Year Period and Activity of Antimicrobial Agents Against Isolates Stratified by β-Lactamase Type. [Abstract]2023 Jan 27;10(2):ofad038. PMID: 36776778
Meropenem purchased from MedChemExpress. Usage Cited in: Open Forum Infect Dis. 2023 Jan 27;10(2):ofad038. [Abstract]
Ceftazidime-avibactam, Meropenem, and Imipenem were the most active β-lactam agents tested against 2663 ESBL-producing E. coli and K. pneumoniae isolates that were carbapenem susceptible
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J Antimicrob Chemother
Harnessing metabolic dependence-driven antibiotic synergy to eradicate tolerant Pseudomonas aeruginosa. [Abstract]2026 Jun 3;81(7):dkag204. PMID: 42267541 -
J Antimicrob Chemother
Comparative activity of established versus new-generation β-lactams against AmpC-hyperproducing clinical isolates of Enterobacter cloacae complex and Klebsiella aerogenes: a multicentre study. [Abstract]2026 Feb 2;81(3):dkag034. PMID: 41648989 -
J Antimicrob Chemother
Unravelling the triad of penicillin-binding proteins, β-lactamase activity, and mRNA dynamics in Pseudomonas aeruginosa AmpC induction. [Abstract]2025 Nov 5:dkaf408. PMID: 41206063 -
J Antimicrob Chemother
In vitro activity of the novel β-lactamase inhibitor taniborbactam (VNRX-5133), in combination with cefepime or meropenem, against MDR Gram-negative bacterial isolates from China. [Abstract]2020 Jul 1;75(7):1850-1858. PMID: 32154866
Meropenem purchased from MedChemExpress. Usage Cited in: J Antimicrob Chemother. 2020 Jul 1;75(7):1850-1858. [Abstract]
The cumulative MIC distributions of Cefepime/Taniborbactam, Ceftazidime/Avibactam and comparator Meropenem for 500 tested isolates. The MICs of cefepime and Cefepime/Taniborbactam shown in the figure were tested by the broth microdilution method. The MICs of Meropenem shown in the figure were tested by the agar dilution method. SS, susceptible to all tested β-lactams. SS-P. aeruginosa, meropenem-susceptible P. aeruginosa. Nine IMP producers included three blaIMP-producing P. aeruginosa.
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J Glob Antimicrob Resist
Exogenous hydrogen sulphide sensitizes carbapenemase-producing Acinetobacter baumannii to gentamicin. [Abstract]2025 Apr 26:S2213-7165(25)00088-8. PMID: 40294863 -
Eur J Clin Microbiol Infect Dis
Evaluation of EUCAST rapid antimicrobial susceptibility testing (RAST) for carbapenemase-producing Klebsiella pneumoniae with focus on KPC variants. [Abstract]2025 Sep 29. PMID: 41023358 -
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Infect Drug Resist
In vitro Activity of Meropenem-Vaborbactam versus Other Antibiotics Against Carbapenem-Resistant Escherichia coli from Southeastern China. [Abstract]2021 Jun 30;14:2499-2507. PMID: 34234477 -
J Antibiot (Tokyo)
Meropenem, Ceftazidime, and Polymyxin B combination therapy: a novel approach to combat antimicrobial resistance in MDR, XDR and PDR Escherichia coli. [Abstract]2026 Feb 17. PMID: 41703045 -
Infect Genet Evol
Polymyxin B combined with amikacin delays the resistance of Klebsiella pneumoniae to polymyxin B by modulating the expression of NlpE. [Abstract]2025 Sep:133:105780. PMID: 40480594 -
J Microbiol Methods
Comparison of agar-based and checkerboard methods to assess phage-antimicrobial synergy in Pseudomonas aeruginosa. [Abstract]2026 Feb 25:107441. PMID: 41759663 -
Diagn Microbiol Infect Dis
2026 Feb;114(2):117181. PMID: 41205476 -
Solvent & Solubility
DMSO : 100 mg/mL (260.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 16.67 mg/mL (43.47 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.52 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.52 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (290 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. L Slaney, et al. In-vitro activity of meropenem against Neisseria gonorrhoeae, Haemophilus influenzae and H. ducreyi from Canada and Kenya. J Antimicrob Chemother. 1989 Sep;24 Suppl A:183-6. [Content Brief]
[2]. George G Zhanel, et al. Comparative review of the carbapenems. Drugs. 2007;67(7):1027-52. [Content Brief]
[3]. Umit Ateskan, et al. Deferoxamine and meropenem combination therapy in experimental acute pancreatitis. Pancreas. 2003 Oct;27(3):247-52. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O / DMSO | 1 mM | 2.6078 mL | 13.0392 mL | 26.0783 mL | 65.1958 mL |
| 5 mM | 0.5216 mL | 2.6078 mL | 5.2157 mL | 13.0392 mL | |
| 10 mM | 0.2608 mL | 1.3039 mL | 2.6078 mL | 6.5196 mL | |
| 15 mM | 0.1739 mL | 0.8693 mL | 1.7386 mL | 4.3464 mL | |
| 20 mM | 0.1304 mL | 0.6520 mL | 1.3039 mL | 3.2598 mL | |
| 25 mM | 0.1043 mL | 0.5216 mL | 1.0431 mL | 2.6078 mL | |
| 30 mM | 0.0869 mL | 0.4346 mL | 0.8693 mL | 2.1732 mL | |
| 40 mM | 0.0652 mL | 0.3260 mL | 0.6520 mL | 1.6299 mL | |
| DMSO | 50 mM | 0.0522 mL | 0.2608 mL | 0.5216 mL | 1.3039 mL |
| 60 mM | 0.0435 mL | 0.2173 mL | 0.4346 mL | 1.0866 mL | |
| 80 mM | 0.0326 mL | 0.1630 mL | 0.3260 mL | 0.8149 mL | |
| 100 mM | 0.0261 mL | 0.1304 mL | 0.2608 mL | 0.6520 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.