Cat. No.: HY-19313

LLY-507

11 Cited Publications

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Based on 11 publication(s) in Google Scholar

LLY-507 is a potent and selective inhibitor of protein-lysine methyltransferase SMYD2. LLY-507 potently inhibits the ability of SMYD2 to methylate p53 peptide with an IC₅₀ <15 nM. LLY-507 serves as a valuable chemical probe to aid in the dissection of SMYD2 function in cancer and other biological processes.

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Pureté: 99.09%
CAS No.: 1793053-37-8
Formule: C₃₆H₄₂N₆O
Masse moléculaire:574.76

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

LLY-507 Chemical Structure

CAS No.: 1793053-37-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (11)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
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Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

SMYD2

<15 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform Histone Methyltransferase :

Cellular Effect

Cell Line	Type	Value	Description	References
5637	IC₅₀	6.75 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human 5637 cells after 10 days Antiproliferative activity against human 5637 cells after 10 days	[PMID: 29856759]
639-V	IC₅₀	1.14 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human 639-V cells after 10 days Antiproliferative activity against human 639-V cells after 10 days	[PMID: 29856759]
647-V	IC₅₀	1.48 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human 647-V cells after 10 days Antiproliferative activity against human 647-V cells after 10 days	[PMID: 29856759]
769-P	IC₅₀	2.76 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human 769-P cells after 10 days Antiproliferative activity against human 769-P cells after 10 days	[PMID: 29856759]
786-0	IC₅₀	2.1 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human 786-0 cells after 10 days Antiproliferative activity against human 786-0 cells after 10 days	[PMID: 29856759]
A 172	IC₅₀	1.96 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human A-172 cells after 10 days Antiproliferative activity against human A-172 cells after 10 days	[PMID: 29856759]
A101D	IC₅₀	1.23 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human A101D cells after 10 days Antiproliferative activity against human A101D cells after 10 days	[PMID: 29856759]
A204	IC₅₀	1.35 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human A204 cells after 10 days Antiproliferative activity against human A204 cells after 10 days	[PMID: 29856759]
A-375	IC₅₀	1.91 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human A-375 cells after 10 days Antiproliferative activity against human A-375 cells after 10 days	[PMID: 29856759]
A-427	IC₅₀	1.34 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human A-427 cells after 10 days Antiproliferative activity against human A-427 cells after 10 days	[PMID: 29856759]
A-431	IC₅₀	6.35 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human A-431 cells after 10 days Antiproliferative activity against human A-431 cells after 10 days	[PMID: 29856759]
A498	IC₅₀	2.01 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human A498 cells after 10 days Antiproliferative activity against human A498 cells after 10 days	[PMID: 29856759]
A549	IC₅₀	3.39 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human A549 cells after 10 days Antiproliferative activity against human A549 cells after 10 days	[PMID: 29856759]
A673	IC₅₀	2.03 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human A673 cells after 10 days Antiproliferative activity against human A673 cells after 10 days	[PMID: 29856759]
ACHN	IC₅₀	3.21 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human ACHN cells after 10 days Antiproliferative activity against human ACHN cells after 10 days	[PMID: 29856759]
AGS	IC₅₀	1.27 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human AGS cells after 10 days Antiproliferative activity against human AGS cells after 10 days	[PMID: 29856759]
AGS	IC₅₀	5.5 μM Compound: LLY-507	Antiproliferative activity against human AGS cells Antiproliferative activity against human AGS cells	[PMID: 33011288]
AN3-CA	IC₅₀	2.42 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human AN3-CA cells after 10 days Antiproliferative activity against human AN3-CA cells after 10 days	[PMID: 29856759]
ARH-77	IC₅₀	0.78 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human ARH-77 cells after 10 days Antiproliferative activity against human ARH-77 cells after 10 days	[PMID: 29856759]
ASPC1	IC₅₀	3.01 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human ASPC1 cells after 10 days Antiproliferative activity against human ASPC1 cells after 10 days	[PMID: 29856759]
AU565	IC₅₀	1.25 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human AU565 cells after 10 days Antiproliferative activity against human AU565 cells after 10 days	[PMID: 29856759]
BC	IC₅₀	1.5 μM Compound: 3; LLY-507	Antitumor activity against human BC cells assessed as inhibition of cell proliferation incubated for 3 to 7 days by CellTiter-Glo assay Antitumor activity against human BC cells assessed as inhibition of cell proliferation incubated for 3 to 7 days by CellTiter-Glo assay	[PMID: 35914250]
BeWo	IC₅₀	2.88 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human BeWo cells after 10 days Antiproliferative activity against human BeWo cells after 10 days	[PMID: 29856759]
BFTC-905	IC₅₀	2.5 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human BFTC-905 cells after 10 days Antiproliferative activity against human BFTC-905 cells after 10 days	[PMID: 29856759]
BHT-101	IC₅₀	1.43 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human BHT-101 cells after 10 days Antiproliferative activity against human BHT-101 cells after 10 days	[PMID: 29856759]
BPH-1	IC₅₀	3.49 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human BPH-1 cells after 10 days Antiproliferative activity against human BPH-1 cells after 10 days	[PMID: 29856759]
BT-20	IC₅₀	3.35 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human BT-20 cells after 10 days Antiproliferative activity against human BT-20 cells after 10 days	[PMID: 29856759]
BT-474	IC₅₀	2.94 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human BT-474 cells after 10 days Antiproliferative activity against human BT-474 cells after 10 days	[PMID: 29856759]
BT-549	IC₅₀	3.29 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human BT-549 cells after 10 days Antiproliferative activity against human BT-549 cells after 10 days	[PMID: 29856759]
BV-173	IC₅₀	1.33 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human BV-173 cells after 10 days Antiproliferative activity against human BV-173 cells after 10 days	[PMID: 29856759]
BXPC-3	IC₅₀	2.87 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human BXPC-3 cells after 10 days Antiproliferative activity against human BXPC-3 cells after 10 days	[PMID: 29856759]
C32	IC₅₀	1.73 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human C32 cells after 10 days Antiproliferative activity against human C32 cells after 10 days	[PMID: 29856759]
C-33-A	IC₅₀	3.23 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human C-33-A cells after 10 days Antiproliferative activity against human C-33-A cells after 10 days	[PMID: 29856759]
C-4-II	IC₅₀	1.78 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human C-4-II cells after 10 days Antiproliferative activity against human C-4-II cells after 10 days	[PMID: 29856759]
CAKI-1	IC₅₀	2.79 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human CAKI-1 cells after 10 days Antiproliferative activity against human CAKI-1 cells after 10 days	[PMID: 29856759]
CAKI-2	IC₅₀	1.22 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human CAKI-2 cells after 10 days Antiproliferative activity against human CAKI-2 cells after 10 days	[PMID: 29856759]
CAL-27	IC₅₀	2.52 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human CAL-27 cells after 10 days Antiproliferative activity against human CAL-27 cells after 10 days	[PMID: 29856759]
CAL-62	IC₅₀	2.07 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human CAL-62 cells after 10 days Antiproliferative activity against human CAL-62 cells after 10 days	[PMID: 29856759]
Calu-1	IC₅₀	2.85 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human Calu-1 cells after 10 days Antiproliferative activity against human Calu-1 cells after 10 days	[PMID: 29856759]
Calu-6	IC₅₀	3.68 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human Calu-6 cells after 10 days Antiproliferative activity against human Calu-6 cells after 10 days	[PMID: 29856759]
CAMA-1	IC₅₀	2.93 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human CAMA-1 cells after 10 days Antiproliferative activity against human CAMA-1 cells after 10 days	[PMID: 29856759]
CAPAN-1	IC₅₀	5.09 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human CAPAN-1 cells after 10 days Antiproliferative activity against human CAPAN-1 cells after 10 days	[PMID: 29856759]
Capan-2	IC₅₀	1.57 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human Capan2 cells after 10 days Antiproliferative activity against human Capan2 cells after 10 days	[PMID: 29856759]
CCF-STTG1	IC₅₀	5.82 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human CCF-STTG1 cells after 10 days Antiproliferative activity against human CCF-STTG1 cells after 10 days	[PMID: 29856759]
CCRF-CEM	IC₅₀	1.79 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human CCRF-CEM cells after 10 days Antiproliferative activity against human CCRF-CEM cells after 10 days	[PMID: 29856759]
CFPAC-1	IC₅₀	1.48 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human CFPAC-1 cells after 10 days Antiproliferative activity against human CFPAC-1 cells after 10 days	[PMID: 29856759]
CGTH-W-1	IC₅₀	2.87 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human CGTH-W-1 cells after 10 days Antiproliferative activity against human CGTH-W-1 cells after 10 days	[PMID: 29856759]
ChaGo-K-1	IC₅₀	1.23 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human ChaGo-K-1 cells after 10 days Antiproliferative activity against human ChaGo-K-1 cells after 10 days	[PMID: 29856759]
CHL-1	IC₅₀	2.57 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human CHL-1 cells after 10 days Antiproliferative activity against human CHL-1 cells after 10 days	[PMID: 29856759]
CHP-212	IC₅₀	2.1 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human CHP-212 cells after 10 days Antiproliferative activity against human CHP-212 cells after 10 days	[PMID: 29856759]
COLO 201	IC₅₀	1.06 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human COLO201 cells after 10 days Antiproliferative activity against human COLO201 cells after 10 days	[PMID: 29856759]
COLO 205	IC₅₀	0.944 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human COLO 205 cells after 10 days Antiproliferative activity against human COLO 205 cells after 10 days	[PMID: 29856759]
COLO 320DM	IC₅₀	2.11 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human COLO 320DM cells after 10 days Antiproliferative activity against human COLO 320DM cells after 10 days	[PMID: 29856759]
COLO-320-HSR	IC₅₀	2.74 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human COLO 320HSR cells after 10 days Antiproliferative activity against human COLO 320HSR cells after 10 days	[PMID: 29856759]
COLO-829	IC₅₀	1.75 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human COLO-829 cells after 10 days Antiproliferative activity against human COLO-829 cells after 10 days	[PMID: 29856759]
COR-L105	IC₅₀	1.11 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human COR-L105 cells after 10 days Antiproliferative activity against human COR-L105 cells after 10 days	[PMID: 29856759]
COR-L23	IC₅₀	2.21 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human COR-L23 cells after 10 days Antiproliferative activity against human COR-L23 cells after 10 days	[PMID: 29856759]
CRO-AP2	IC₅₀	2.26 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human CRO-AP2 cells after 10 days Antiproliferative activity against human CRO-AP2 cells after 10 days	[PMID: 29856759]
CWR22R	IC₅₀	1.06 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human 22Rv1 cells after 10 days Antiproliferative activity against human 22Rv1 cells after 10 days	[PMID: 29856759]
D283 Med	IC₅₀	2.51 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human D283 Med cells after 10 days Antiproliferative activity against human D283 Med cells after 10 days	[PMID: 29856759]
Daoy	IC₅₀	3.67 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human Daoy cells after 10 days Antiproliferative activity against human Daoy cells after 10 days	[PMID: 29856759]
Daudi	IC₅₀	0.857 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human Daudi cells after 10 days Antiproliferative activity against human Daudi cells after 10 days	[PMID: 29856759]
DB	IC₅₀	1.17 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human DB cells after 10 days Antiproliferative activity against human DB cells after 10 days	[PMID: 29856759]
DBTRG-05MG	IC₅₀	1.72 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human DBTRG-05MG cells after 10 days Antiproliferative activity against human DBTRG-05MG cells after 10 days	[PMID: 29856759]
Detroit 562	IC₅₀	1.75 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human Detroit 562 cells after 10 days Antiproliferative activity against human Detroit 562 cells after 10 days	[PMID: 29856759]
DK-MG	IC₅₀	6.42 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human DK-MG cells after 10 days Antiproliferative activity against human DK-MG cells after 10 days	[PMID: 29856759]
DLD-1	IC₅₀	3.4 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human DLD-1 cells after 10 days Antiproliferative activity against human DLD-1 cells after 10 days	[PMID: 29856759]
DMS-114	IC₅₀	2.33 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human DMS-114 cells after 10 days Antiproliferative activity against human DMS-114 cells after 10 days	[PMID: 29856759]
DMS-273	IC₅₀	0.987 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human DMS-273 cells after 10 days Antiproliferative activity against human DMS-273 cells after 10 days	[PMID: 29856759]
DMS-53	IC₅₀	3.17 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human DMS-53 cells after 10 days Antiproliferative activity against human DMS-53 cells after 10 days	[PMID: 29856759]
DOHH-2	IC₅₀	0.263 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human DOHH-2 cells after 10 days Antiproliferative activity against human DOHH-2 cells after 10 days	[PMID: 29856759]
DoTc2-4510	IC₅₀	1.07 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human DoTc2-4510 cells after 10 days Antiproliferative activity against human DoTc2-4510 cells after 10 days	[PMID: 29856759]
DU-145	IC₅₀	4.13 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human DU-145 cells after 10 days Antiproliferative activity against human DU-145 cells after 10 days	[PMID: 29856759]
EB-3	IC₅₀	0.329 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human EB-3 cells after 10 days Antiproliferative activity against human EB-3 cells after 10 days	[PMID: 29856759]
EFM-19	IC₅₀	2.68 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human EFM-19 cells after 10 days Antiproliferative activity against human EFM-19 cells after 10 days	[PMID: 29856759]
EM-2	IC₅₀	2.22 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human EM-2 cells after 10 days Antiproliferative activity against human EM-2 cells after 10 days	[PMID: 29856759]
ES-2	IC₅₀	1.32 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human ES2 cells after 10 days Antiproliferative activity against human ES2 cells after 10 days	[PMID: 29856759]
FaDu	IC₅₀	2.36 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human FaDu cells after 10 days Antiproliferative activity against human FaDu cells after 10 days	[PMID: 29856759]
G-401	IC₅₀	0.905 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human G-401 cells after 10 days Antiproliferative activity against human G-401 cells after 10 days	[PMID: 29856759]
G-402	IC₅₀	2.19 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human G-402 cells after 10 days Antiproliferative activity against human G-402 cells after 10 days	[PMID: 29856759]
H4	IC₅₀	1.88 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human H4 cells after 10 days Antiproliferative activity against human H4 cells after 10 days	[PMID: 29856759]
HCT-116	IC₅₀	2.66 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human HCT-116 cells after 10 days Antiproliferative activity against human HCT-116 cells after 10 days	[PMID: 29856759]
HCT-15	IC₅₀	1.7 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human HCT-15 cells after 10 days Antiproliferative activity against human HCT-15 cells after 10 days	[PMID: 29856759]
HCT-8	IC₅₀	2.52 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human HCT-8 cells after 10 days Antiproliferative activity against human HCT-8 cells after 10 days	[PMID: 29856759]
HEC-1-A	IC₅₀	1.05 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human HEC-1-A cells after 10 days Antiproliferative activity against human HEC-1-A cells after 10 days	[PMID: 29856759]
HEL 92.1.7	IC₅₀	3.53 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human HEL 92.1.7 cells after 10 days Antiproliferative activity against human HEL 92.1.7 cells after 10 days	[PMID: 29856759]
HeLa	IC₅₀	2.96 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human HeLa cells after 10 days Antiproliferative activity against human HeLa cells after 10 days	[PMID: 29856759]
Hep 3B2	IC₅₀	0.3 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human Hep3B cells measured after 7 day by celltitre-glo luminescent assay Antiproliferative activity against human Hep3B cells measured after 7 day by celltitre-glo luminescent assay	[PMID: 25825497]
Hep 3B2	IC₅₀	1.5 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human Hep3B cells measured after 3 to 4 day by celltitre-glo luminescent assay Antiproliferative activity against human Hep3B cells measured after 3 to 4 day by celltitre-glo luminescent assay	[PMID: 25825497]
HepG2	IC₅₀	0.3 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human HepG2 cells measured after 7 day by celltitre-glo luminescent assay Antiproliferative activity against human HepG2 cells measured after 7 day by celltitre-glo luminescent assay	[PMID: 25825497]
HepG2	IC₅₀	1.5 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human HepG2 cells measured after 3 to 4 day by celltitre-glo luminescent assay Antiproliferative activity against human HepG2 cells measured after 3 to 4 day by celltitre-glo luminescent assay	[PMID: 25825497]
HepG2	IC₅₀	2.35 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human HepG2 cells after 10 days Antiproliferative activity against human HepG2 cells after 10 days	[PMID: 29856759]
HLE	IC₅₀	1.88 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human HLE cells after 10 days Antiproliferative activity against human HLE cells after 10 days	[PMID: 29856759]
HOS	IC₅₀	2.13 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human HOS cells after 10 days Antiproliferative activity against human HOS cells after 10 days	[PMID: 29856759]
HPAF-II	IC₅₀	1.6 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human HPAF-II cells after 10 days Antiproliferative activity against human HPAF-II cells after 10 days	[PMID: 29856759]
Hs 294T	IC₅₀	2.48 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human Hs 294T cells after 10 days Antiproliferative activity against human Hs 294T cells after 10 days	[PMID: 29856759]
Hs 695T	IC₅₀	6.65 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human Hs 695T cells after 10 days Antiproliferative activity against human Hs 695T cells after 10 days	[PMID: 29856759]
Hs 766	IC₅₀	2.75 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human Hs766T cells after 10 days Antiproliferative activity against human Hs766T cells after 10 days	[PMID: 29856759]
Hs-578T	IC₅₀	6.14 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human Hs 578T cells after 10 days Antiproliferative activity against human Hs 578T cells after 10 days	[PMID: 29856759]
Hs746T	IC₅₀	4.29 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human Hs746T cells after 10 days Antiproliferative activity against human Hs746T cells after 10 days	[PMID: 29856759]
HT	IC₅₀	1.93 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human HT cells after 10 days Antiproliferative activity against human HT cells after 10 days	[PMID: 29856759]
HT-1080	IC₅₀	1.98 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human HT-1080 cells after 10 days Antiproliferative activity against human HT-1080 cells after 10 days	[PMID: 29856759]
HT1197	IC₅₀	1.56 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human HT1197 cells after 10 days Antiproliferative activity against human HT1197 cells after 10 days	[PMID: 29856759]
HT-1376	IC₅₀	2.35 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human HT-1376 cells after 10 days Antiproliferative activity against human HT-1376 cells after 10 days	[PMID: 29856759]
HT-29	IC₅₀	1.26 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human HT-29 cells after 10 days Antiproliferative activity against human HT-29 cells after 10 days	[PMID: 29856759]
HT-3	IC₅₀	3.27 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human HT-3 cells after 10 days Antiproliferative activity against human HT-3 cells after 10 days	[PMID: 29856759]
HuCCT-1	IC₅₀	1.24 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human HuCCT-1 cells after 10 days Antiproliferative activity against human HuCCT-1 cells after 10 days	[PMID: 29856759]
HUH-6-clone5	IC₅₀	1.34 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human HUH-6-clone5 cells after 10 days Antiproliferative activity against human HUH-6-clone5 cells after 10 days	[PMID: 29856759]
Huh-7	IC₅₀	0.3 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human Huh-7 cells measured after 7 day by celltitre-glo luminescent assay Antiproliferative activity against human Huh-7 cells measured after 7 day by celltitre-glo luminescent assay	[PMID: 25825497]
Huh-7	IC₅₀	1.5 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human Huh-7 cells measured after 3 to 4 day by celltitre-glo luminescent assay Antiproliferative activity against human Huh-7 cells measured after 3 to 4 day by celltitre-glo luminescent assay	[PMID: 25825497]
HuP-T4	IC₅₀	3.48 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human HuP-T4 cells after 10 days Antiproliferative activity against human HuP-T4 cells after 10 days	[PMID: 29856759]
J82	IC₅₀	3.15 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human J82 cells after 10 days Antiproliferative activity against human J82 cells after 10 days	[PMID: 29856759]
JAR	IC₅₀	2.88 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human JAR cells after 10 days Antiproliferative activity against human JAR cells after 10 days	[PMID: 29856759]
JEG-3	IC₅₀	1.5 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human JEG-3 cells after 10 days Antiproliferative activity against human JEG-3 cells after 10 days	[PMID: 29856759]
J-RT3-T3-5	IC₅₀	1.18 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human J-RT3-T3-5 cells after 10 days Antiproliferative activity against human J-RT3-T3-5 cells after 10 days	[PMID: 29856759]
Jurkat	IC₅₀	0.925 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human Jurkat cells after 10 days Antiproliferative activity against human Jurkat cells after 10 days	[PMID: 29856759]
K562	IC₅₀	3.21 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human K562 cells after 10 days Antiproliferative activity against human K562 cells after 10 days	[PMID: 29856759]
KLE	IC₅₀	3.21 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human KLE cells after 10 days Antiproliferative activity against human KLE cells after 10 days	[PMID: 29856759]
KYSE-140	IC₅₀	0.3 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human KYSE-140 cells measured after 7 day by celltitre-glo luminescent assay Antiproliferative activity against human KYSE-140 cells measured after 7 day by celltitre-glo luminescent assay	[PMID: 25825497]
KYSE-140	IC₅₀	1.5 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human KYSE-140 cells measured after 3 to 4 day by celltitre-glo luminescent assay Antiproliferative activity against human KYSE-140 cells measured after 3 to 4 day by celltitre-glo luminescent assay	[PMID: 25825497]
KYSE-150 cell line	IC₅₀	1.5 μM Compound: 3; LLY-507	Antitumor activity against human KYSE-150 cells assessed as inhibition of cell proliferation incubated for 3 to 7 days by CellTiter-Glo assay Antitumor activity against human KYSE-150 cells assessed as inhibition of cell proliferation incubated for 3 to 7 days by CellTiter-Glo assay	[PMID: 35914250]
KYSE-270	IC₅₀	0.3 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human KYSE-270 cells measured after 7 day by celltitre-glo luminescent assay Antiproliferative activity against human KYSE-270 cells measured after 7 day by celltitre-glo luminescent assay	[PMID: 25825497]
KYSE-270	IC₅₀	1.5 μM Compound: 3; LLY-507	Antitumor activity against human KYSE-270 cells assessed as inhibition of cell proliferation incubated for 3 to 7 days by CellTiter-Glo assay Antitumor activity against human KYSE-270 cells assessed as inhibition of cell proliferation incubated for 3 to 7 days by CellTiter-Glo assay	[PMID: 35914250]
KYSE-270	IC₅₀	1.5 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human KYSE-270 cells measured after 3 to 4 day by celltitre-glo luminescent assay Antiproliferative activity against human KYSE-270 cells measured after 3 to 4 day by celltitre-glo luminescent assay	[PMID: 25825497]
KYSE-30	IC₅₀	0.3 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human KYSE-30 cells measured after 7 day by celltitre-glo luminescent assay Antiproliferative activity against human KYSE-30 cells measured after 7 day by celltitre-glo luminescent assay	[PMID: 25825497]
KYSE-30	IC₅₀	1.5 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human KYSE-30 cells measured after 3 to 4 day by celltitre-glo luminescent assay Antiproliferative activity against human KYSE-30 cells measured after 3 to 4 day by celltitre-glo luminescent assay	[PMID: 25825497]
L-428	IC₅₀	1.49 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human L-428 cells after 10 days Antiproliferative activity against human L-428 cells after 10 days	[PMID: 29856759]
LNCaP	IC₅₀	3.44 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human LNCaP cells after 10 days Antiproliferative activity against human LNCaP cells after 10 days	[PMID: 29856759]
LS-1034	IC₅₀	2.9 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human LS1034 cells after 10 days Antiproliferative activity against human LS1034 cells after 10 days	[PMID: 29856759]
LS174T	IC₅₀	1.47 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human LS174T cells after 10 days Antiproliferative activity against human LS174T cells after 10 days	[PMID: 29856759]
Malme-3M	IC₅₀	2.4 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human Malme-3M cells after 10 days Antiproliferative activity against human Malme-3M cells after 10 days	[PMID: 29856759]
MCF7	IC₅₀	0.3 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human MCF7 cells measured after 7 day by celltitre-glo luminescent assay Antiproliferative activity against human MCF7 cells measured after 7 day by celltitre-glo luminescent assay	[PMID: 25825497]
MCF7	IC₅₀	1.5 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human MCF7 cells measured after 3 to 4 day by celltitre-glo luminescent assay Antiproliferative activity against human MCF7 cells measured after 3 to 4 day by celltitre-glo luminescent assay	[PMID: 25825497]
MCF7	IC₅₀	3.11 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human MCF7 cells after 10 days Antiproliferative activity against human MCF7 cells after 10 days	[PMID: 29856759]
MC-IXC	IC₅₀	1.92 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human MC-IXC cells after 10 days Antiproliferative activity against human MC-IXC cells after 10 days	[PMID: 29856759]
MDA-MB-231	IC₅₀	0.3 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human MDA-MB-231 cells measured after 7 day by celltitre-glo luminescent assay Antiproliferative activity against human MDA-MB-231 cells measured after 7 day by celltitre-glo luminescent assay	[PMID: 25825497]
MDA-MB-231	IC₅₀	1.07 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human MDA-MB-231 cells after 10 days Antiproliferative activity against human MDA-MB-231 cells after 10 days	[PMID: 29856759]
MDA-MB-231	IC₅₀	1.5 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human MDA-MB-231 cells measured after 3 to 4 day by celltitre-glo luminescent assay Antiproliferative activity against human MDA-MB-231 cells measured after 3 to 4 day by celltitre-glo luminescent assay	[PMID: 25825497]
MDA-MB-436	IC₅₀	3.03 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human MDA-MB-436 cells after 10 days Antiproliferative activity against human MDA-MB-436 cells after 10 days	[PMID: 29856759]
MDA-MB-453	IC₅₀	1.5 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human MDA-MB-453 cells after 10 days Antiproliferative activity against human MDA-MB-453 cells after 10 days	[PMID: 29856759]
MDA-MB-468	IC₅₀	1.89 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human MDA-MB-468 cells after 10 days Antiproliferative activity against human MDA-MB-468 cells after 10 days	[PMID: 29856759]
MEG-01	IC₅₀	1.28 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human MEG-01 cells after 10 days Antiproliferative activity against human MEG-01 cells after 10 days	[PMID: 29856759]
MES-SA	IC₅₀	2.3 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human MES-SA cells after 10 days Antiproliferative activity against human MES-SA cells after 10 days	[PMID: 29856759]
MeWo	IC₅₀	1.98 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human MeWo cells after 10 days Antiproliferative activity against human MeWo cells after 10 days	[PMID: 29856759]
MG-63	IC₅₀	6.12 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human MG-63 cells after 10 days Antiproliferative activity against human MG-63 cells after 10 days	[PMID: 29856759]
MHH-PREB-1	IC₅₀	1.06 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human MHH-PREB-1 cells after 10 days Antiproliferative activity against human MHH-PREB-1 cells after 10 days	[PMID: 29856759]
MIA PaCa-2	IC₅₀	2.03 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human Mia PaCa-2 cells after 10 days Antiproliferative activity against human Mia PaCa-2 cells after 10 days	[PMID: 29856759]
MOLT-16	IC₅₀	1.11 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human MOLT-16 cells after 10 days Antiproliferative activity against human MOLT-16 cells after 10 days	[PMID: 29856759]
MOLT-3	IC₅₀	1.36 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human MOLT-3 cells after 10 days Antiproliferative activity against human MOLT-3 cells after 10 days	[PMID: 29856759]
MV4-11	IC₅₀	1.01 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human MV4-11 cells after 10 days Antiproliferative activity against human MV4-11 cells after 10 days	[PMID: 29856759]
MX1	IC₅₀	0.3 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human MX1 cells measured after 7 day by celltitre-glo luminescent assay Antiproliferative activity against human MX1 cells measured after 7 day by celltitre-glo luminescent assay	[PMID: 25825497]
MX1	IC₅₀	1.5 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human MX1 cells measured after 3 to 4 day by celltitre-glo luminescent assay Antiproliferative activity against human MX1 cells measured after 3 to 4 day by celltitre-glo luminescent assay	[PMID: 25825497]
MX1	IC₅₀	1.5 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human MX1 cells after 10 days Antiproliferative activity against human MX1 cells after 10 days	[PMID: 29856759]
NALM-6	IC₅₀	1.14 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human NALM-6 cells after 10 days Antiproliferative activity against human NALM-6 cells after 10 days	[PMID: 29856759]
NCI-H292	IC₅₀	2.69 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human NCI-H292 cells after 10 days Antiproliferative activity against human NCI-H292 cells after 10 days	[PMID: 29856759]
NCI-H295R	IC₅₀	4.84 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human NCI-H295R cells after 10 days Antiproliferative activity against human NCI-H295R cells after 10 days	[PMID: 29856759]
NCI-H441	IC₅₀	5.63 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human NCI-H441 cells after 10 days Antiproliferative activity against human NCI-H441 cells after 10 days	[PMID: 29856759]
NCI-H446	IC₅₀	3.16 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human NCI-H446 cells after 10 days Antiproliferative activity against human NCI-H446 cells after 10 days	[PMID: 29856759]
NCI-H460	IC₅₀	1.78 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human NCI-H460 cells after 10 days Antiproliferative activity against human NCI-H460 cells after 10 days	[PMID: 29856759]
NCI-H508	IC₅₀	3.09 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human NCI-H508 cells after 10 days Antiproliferative activity against human NCI-H508 cells after 10 days	[PMID: 29856759]
NCI-H520	IC₅₀	2.7 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human NCI-H520 cells after 10 days Antiproliferative activity against human NCI-H520 cells after 10 days	[PMID: 29856759]
NCI-H596	IC₅₀	2.95 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human NCI-H596 cells after 10 days Antiproliferative activity against human NCI-H596 cells after 10 days	[PMID: 29856759]
NCI-H661	IC₅₀	3.39 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human NCI-H661 cells after 10 days Antiproliferative activity against human NCI-H661 cells after 10 days	[PMID: 29856759]
NCI-H69	IC₅₀	2.74 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human NCI-H69 cells after 10 days Antiproliferative activity against human NCI-H69 cells after 10 days	[PMID: 29856759]
NCI-H747	IC₅₀	2.32 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human NCI-H747 cells after 10 days Antiproliferative activity against human NCI-H747 cells after 10 days	[PMID: 29856759]
NCI-N87	IC₅₀	7 μM Compound: LLY-507	Antiproliferative activity against human NCI-N87 cells Antiproliferative activity against human NCI-N87 cells	[PMID: 33011288]
OE19	IC₅₀	2.52 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human OE19 cells after 10 days Antiproliferative activity against human OE19 cells after 10 days	[PMID: 29856759]
OE33	IC₅₀	2 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human OE33 cells after 10 days Antiproliferative activity against human OE33 cells after 10 days	[PMID: 29856759]
OVCAR-3	IC₅₀	3.95 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human OVCAR-3 cells after 10 days Antiproliferative activity against human OVCAR-3 cells after 10 days	[PMID: 29856759]
PANC-1	IC₅₀	2.87 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human PANC-1 cells after 10 days Antiproliferative activity against human PANC-1 cells after 10 days	[PMID: 29856759]
PC-3	IC₅₀	2.77 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human PC-3 cells after 10 days Antiproliferative activity against human PC-3 cells after 10 days	[PMID: 29856759]
Raji	IC₅₀	1.59 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human Raji cells after 10 days Antiproliferative activity against human Raji cells after 10 days	[PMID: 29856759]
Ramos	IC₅₀	1.04 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human Ramos cells after 10 days Antiproliferative activity against human Ramos cells after 10 days	[PMID: 29856759]
RD	IC₅₀	0.954 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human RD cells after 10 days Antiproliferative activity against human RD cells after 10 days	[PMID: 29856759]
RKO	IC₅₀	1.04 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human RKO cells after 10 days Antiproliferative activity against human RKO cells after 10 days	[PMID: 29856759]
RL95-2	IC₅₀	1.29 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human RL95-2 cells after 10 days Antiproliferative activity against human RL95-2 cells after 10 days	[PMID: 29856759]
RPMI-6666	IC₅₀	2.91 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human RPMI-6666 cells after 10 days Antiproliferative activity against human RPMI-6666 cells after 10 days	[PMID: 29856759]
RPMI-7951	IC₅₀	2.05 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human RPMI-7951 cells after 10 days Antiproliferative activity against human RPMI-7951 cells after 10 days	[PMID: 29856759]
RPMI-8226	IC₅₀	1.56 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human RPMI-8226 cells after 10 days Antiproliferative activity against human RPMI-8226 cells after 10 days	[PMID: 29856759]
SAOS-2	IC₅₀	3.03 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SAOS-2 cells after 10 days Antiproliferative activity against human SAOS-2 cells after 10 days	[PMID: 29856759]
SCaBER	IC₅₀	1.5 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SCaBER cells after 10 days Antiproliferative activity against human SCaBER cells after 10 days	[PMID: 29856759]
SCC-25	IC₅₀	2.52 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SCC-25 cells after 10 days Antiproliferative activity against human SCC-25 cells after 10 days	[PMID: 29856759]
SCC-4	IC₅₀	3.59 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SCC-4 cells after 10 days Antiproliferative activity against human SCC-4 cells after 10 days	[PMID: 29856759]
SCC-9	IC₅₀	1.18 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SCC-9 cells after 10 days Antiproliferative activity against human SCC-9 cells after 10 days	[PMID: 29856759]
SH-4	IC₅₀	1.15 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SH-4 cells after 10 days Antiproliferative activity against human SH-4 cells after 10 days	[PMID: 29856759]
SHP77	IC₅₀	1.65 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SHP77 cells after 10 days Antiproliferative activity against human SHP77 cells after 10 days	[PMID: 29856759]
SiHa	IC₅₀	3.26 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SiHa cells after 10 days Antiproliferative activity against human SiHa cells after 10 days	[PMID: 29856759]
SJRH30	IC₅₀	1.23 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SJRH30 cells after 10 days Antiproliferative activity against human SJRH30 cells after 10 days	[PMID: 29856759]
SJSA-1	IC₅₀	1.47 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SJSA-1 cells after 10 days Antiproliferative activity against human SJSA-1 cells after 10 days	[PMID: 29856759]
SK-BR-3	IC₅₀	1.17 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SK-BR-3 cells after 10 days Antiproliferative activity against human SK-BR-3 cells after 10 days	[PMID: 29856759]
SK-HEP1	IC₅₀	0.3 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human SK-HEP1 cells measured after 7 day by celltitre-glo luminescent assay Antiproliferative activity against human SK-HEP1 cells measured after 7 day by celltitre-glo luminescent assay	[PMID: 25825497]
SK-HEP1	IC₅₀	1.5 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human SK-HEP1 cells measured after 3 to 4 day by celltitre-glo luminescent assay Antiproliferative activity against human SK-HEP1 cells measured after 3 to 4 day by celltitre-glo luminescent assay	[PMID: 25825497]
SK-LMS-1	IC₅₀	2.41 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SK-LMS-1 cells after 10 days Antiproliferative activity against human SK-LMS-1 cells after 10 days	[PMID: 29856759]
SK-MEL-1	IC₅₀	1.9 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SK-MEL-1 cells after 10 days Antiproliferative activity against human SK-MEL-1 cells after 10 days	[PMID: 29856759]
SK-MEL-28	IC₅₀	1.77 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SK-MEL-28 cells after 10 days Antiproliferative activity against human SK-MEL-28 cells after 10 days	[PMID: 29856759]
SK-MEL3	IC₅₀	1.39 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SK-MEL3 cells after 10 days Antiproliferative activity against human SK-MEL3 cells after 10 days	[PMID: 29856759]
SK-MES-1	IC₅₀	1.18 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SK-MES-1 cells after 10 days Antiproliferative activity against human SK-MES-1 cells after 10 days	[PMID: 29856759]
SK-N-AS	IC₅₀	1.81 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SK-N-AS cells after 10 days Antiproliferative activity against human SK-N-AS cells after 10 days	[PMID: 29856759]
SK-N-DZ	IC₅₀	3.76 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SK-N-DZ cells after 10 days Antiproliferative activity against human SK-N-DZ cells after 10 days	[PMID: 29856759]
SK-NEP-1	IC₅₀	3.18 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SK-NEP-1 cells after 10 days Antiproliferative activity against human SK-NEP-1 cells after 10 days	[PMID: 29856759]
SK-N-FI	IC₅₀	6.03 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SK-N-FI cells after 10 days Antiproliferative activity against human SK-N-FI cells after 10 days	[PMID: 29856759]
SK-OV-3	IC₅₀	2.95 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SK-OV-3 cells after 10 days Antiproliferative activity against human SK-OV-3 cells after 10 days	[PMID: 29856759]
SK-UT-1	IC₅₀	1.41 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SK-UT-1 cells after 10 days Antiproliferative activity against human SK-UT-1 cells after 10 days	[PMID: 29856759]
SNB-19	IC₅₀	2.52 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SNB-19 cells after 10 days Antiproliferative activity against human SNB-19 cells after 10 days	[PMID: 29856759]
SNU1	IC₅₀	1.19 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SNU1 cells after 10 days Antiproliferative activity against human SNU1 cells after 10 days	[PMID: 29856759]
SNU-16	IC₅₀	0.993 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SNU-16 cells after 10 days Antiproliferative activity against human SNU-16 cells after 10 days	[PMID: 29856759]
SNU-423	IC₅₀	1.11 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SNU-423 cells after 10 days Antiproliferative activity against human SNU-423 cells after 10 days	[PMID: 29856759]
SNU-449	IC₅₀	0.3 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human SNU-449 cells measured after 7 day by celltitre-glo luminescent assay Antiproliferative activity against human SNU-449 cells measured after 7 day by celltitre-glo luminescent assay	[PMID: 25825497]
SNU-449	IC₅₀	1.5 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human SNU-449 cells measured after 3 to 4 day by celltitre-glo luminescent assay Antiproliferative activity against human SNU-449 cells measured after 3 to 4 day by celltitre-glo luminescent assay	[PMID: 25825497]
SNU-5	IC₅₀	3.32 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SNU-5 cells after 10 days Antiproliferative activity against human SNU-5 cells after 10 days	[PMID: 29856759]
SR	IC₅₀	0.708 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SR cells after 10 days Antiproliferative activity against human SR cells after 10 days	[PMID: 29856759]
ST486	IC₅₀	0.955 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human ST486 cells after 10 days Antiproliferative activity against human ST486 cells after 10 days	[PMID: 29856759]
SU.86.86	IC₅₀	3.55 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SU-86-86 cells after 10 days Antiproliferative activity against human SU-86-86 cells after 10 days	[PMID: 29856759]
SW 954	IC₅₀	4.07 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SW 954 cells after 10 days Antiproliferative activity against human SW 954 cells after 10 days	[PMID: 29856759]
SW 962	IC₅₀	3.38 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SW 962 cells after 10 days Antiproliferative activity against human SW 962 cells after 10 days	[PMID: 29856759]
SW1088	IC₅₀	1.18 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SW1088 cells after 10 days Antiproliferative activity against human SW1088 cells after 10 days	[PMID: 29856759]
SW13	IC₅₀	2.68 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SW13 cells after 10 days Antiproliferative activity against human SW13 cells after 10 days	[PMID: 29856759]
SW1353	IC₅₀	2.98 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SW1353 cells after 10 days Antiproliferative activity against human SW1353 cells after 10 days	[PMID: 29856759]
SW1417	IC₅₀	3.23 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SW1417 cells after 10 days Antiproliferative activity against human SW1417 cells after 10 days	[PMID: 29856759]
SW1463	IC₅₀	3.06 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SW1463 cells after 10 days Antiproliferative activity against human SW1463 cells after 10 days	[PMID: 29856759]
SW1783	IC₅₀	2.96 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SW1783 cells after 10 days Antiproliferative activity against human SW1783 cells after 10 days	[PMID: 29856759]
SW48	IC₅₀	1.35 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SW48 cells after 10 days Antiproliferative activity against human SW48 cells after 10 days	[PMID: 29856759]
SW480	IC₅₀	2.15 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SW480 cells after 10 days Antiproliferative activity against human SW480 cells after 10 days	[PMID: 29856759]
SW-620	IC₅₀	3.08 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SW620 cells after 10 days Antiproliferative activity against human SW620 cells after 10 days	[PMID: 29856759]
SW684	IC₅₀	5.75 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SW684 cells after 10 days Antiproliferative activity against human SW684 cells after 10 days	[PMID: 29856759]
SW837	IC₅₀	3.69 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SW837 cells after 10 days Antiproliferative activity against human SW837 cells after 10 days	[PMID: 29856759]
SW872	IC₅₀	2.53 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SW872 cells after 10 days Antiproliferative activity against human SW872 cells after 10 days	[PMID: 29856759]
SW900	IC₅₀	3.22 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SW900 cells after 10 days Antiproliferative activity against human SW900 cells after 10 days	[PMID: 29856759]
SW948	IC₅₀	3.91 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SW948 cells after 10 days Antiproliferative activity against human SW948 cells after 10 days	[PMID: 29856759]
SW982	IC₅₀	5.79 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human SW982 cells after 10 days Antiproliferative activity against human SW982 cells after 10 days	[PMID: 29856759]
T-24	IC₅₀	2.94 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human T24 cells after 10 days Antiproliferative activity against human T24 cells after 10 days	[PMID: 29856759]
T47D	IC₅₀	2.22 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human T47D cells after 10 days Antiproliferative activity against human T47D cells after 10 days	[PMID: 29856759]
T98G	IC₅₀	5.87 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human T98G cells after 10 days Antiproliferative activity against human T98G cells after 10 days	[PMID: 29856759]
TCC-SUP	IC₅₀	2.26 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human TCC-SUP cells after 10 days Antiproliferative activity against human TCC-SUP cells after 10 days	[PMID: 29856759]
THP-1	IC₅₀	2.86 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human THP-1 cells after 10 days Antiproliferative activity against human THP-1 cells after 10 days	[PMID: 29856759]
TOV21G	IC₅₀	1.2 μM Compound: LLY-507	Anti-proliferative activity against human TOV-21G cells assessed as cell viability incubated for 24 hrs by CCK-8 assay Anti-proliferative activity against human TOV-21G cells assessed as cell viability incubated for 24 hrs by CCK-8 assay	[PMID: 32934721]
U138-MG	IC₅₀	4.54 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human U138-MG cells after 10 days Antiproliferative activity against human U138-MG cells after 10 days	[PMID: 29856759]
U-266	IC₅₀	1.26 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human U266B1 cells after 10 days Antiproliferative activity against human U266B1 cells after 10 days	[PMID: 29856759]
U2OS	IC₅₀	1.68 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human U2OS cells after 10 days Antiproliferative activity against human U2OS cells after 10 days	[PMID: 29856759]
U2OS	IC₅₀	600 nM Compound: 2; LLY-507	Inhibition of SMYD2 (unknown origin) expressed in human U2OS cells assessed as reduction in p53 methylation by Western blot analysis Inhibition of SMYD2 (unknown origin) expressed in human U2OS cells assessed as reduction in p53 methylation by Western blot analysis	[PMID: 27075367]
U-87MG ATCC	IC₅₀	2.85 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human U-87MG cells after 10 days Antiproliferative activity against human U-87MG cells after 10 days	[PMID: 29856759]
UACC-812	IC₅₀	0.3 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human UACC-812 cells measured after 7 day by celltitre-glo luminescent assay Antiproliferative activity against human UACC-812 cells measured after 7 day by celltitre-glo luminescent assay	[PMID: 25825497]
UACC-812	IC₅₀	1.5 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human UACC-812 cells measured after 3 to 4 day by celltitre-glo luminescent assay Antiproliferative activity against human UACC-812 cells measured after 3 to 4 day by celltitre-glo luminescent assay	[PMID: 25825497]
UACC-893	IC₅₀	0.3 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human UACC-893 cells measured after 7 day by celltitre-glo luminescent assay Antiproliferative activity against human UACC-893 cells measured after 7 day by celltitre-glo luminescent assay	[PMID: 25825497]
UACC-893	IC₅₀	1.5 μM Compound: Chemical Probe: LLY-507	Antiproliferative activity against human UACC-893 cells measured after 3 to 4 day by celltitre-glo luminescent assay Antiproliferative activity against human UACC-893 cells measured after 3 to 4 day by celltitre-glo luminescent assay	[PMID: 25825497]
UMUC3	IC₅₀	2.91 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human UM-UC-3 cells after 10 days Antiproliferative activity against human UM-UC-3 cells after 10 days	[PMID: 29856759]
WiDr	IC₅₀	0.838 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human WiDr cells after 10 days Antiproliferative activity against human WiDr cells after 10 days	[PMID: 29856759]
Y79	IC₅₀	3.53 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human Y79 cells after 10 days Antiproliferative activity against human Y79 cells after 10 days	[PMID: 29856759]
YAPC	IC₅₀	2.87 μM Compound: Chemical probe: LLY-507	Antiproliferative activity against human YAPC cells after 10 days Antiproliferative activity against human YAPC cells after 10 days	[PMID: 29856759]

In Vitro

LLY-507 is >100-fold selective for SMYD2 over 21 other methyltransferases including SMYD3^[1].
LLY-507 binds to the substrate channel of SMYD2 and supports the selectivity of its inhibition^[1].
LY-507 is able to potently inhibit the methylation of H4 peptide by SMYD2 enzyme with an IC₅₀ of 31 nM^[1].
LLY-507 (0.03-20 μM; 28 hours) inhibits SMYD2-mediated methylation of p53 Lys³⁷⁰ in U2OS cells, with an IC₅₀ of 0.6 μM^[1].
LLY-507 (0-20 μM; 3-7 days) inhibits the proliferation of several ESCC, HCC, and breast cancer cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

ESCC, HCC, breast cancer cell lines
Concentration:

0-20 μM
Incubation Time:

3 days, 7 days
Result:

Inhibited tumor cell proliferation.

Western Blot Analysis^[1]

Cell Line:

HEK293 cells
Concentration:

0.03 μM, 0.07 μM, 0.15 μM, 0.3 μM, 0.6 μM, 1.25 μM, 2.5 μM
Incubation Time:

28 hours
Result:

Inhibited SMYD2-mediated methylation of p53 Lys³⁷⁰ in cells.

Chemical Information

CAS No. 1793053-37-8
Appearance Solid
Masse moléculaire 574.76
Formule C₃₆H₄₂N₆O
Color White to off-white
SMILES

O=C(C1=CC(C2=CC=CC=C2N3CCN(CCN4C=C(C)C5=C4C=CC=C5)CC3)=CC(C#N)=C1)NCCCN6CCCC6
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (11)

All WB

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Journal Impact Factor

Nat Commun

Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]

2026 Feb 12;17(1):1214. PMID: 41680175
Exp Mol Med

Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis. [Abstract]

2023 May;55(5):952-964. PMID: 37121971
Cell Death Dis

Histone methyltransferase Smyd2 drives adipogenesis via regulating STAT3 phosphorylation. [Abstract]

2022 Oct 21;13(10):890. PMID: 36270984
Cell Death Dis

Targeting EHMT2 reverses EGFR-TKI resistance in NSCLC by epigenetically regulating the PTEN/AKT signaling pathway. [Abstract]

2018 Jan 26;9(2):129. PMID: 29374157

LLY-507 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129. [Abstract]

The effects of treatment with the indicated epigenetic inhibitors on cleaved PARP (Clv-PARP) expression in both PC9/ER and HCC827/ER cells. β-actin is used as a loading control.
Diabetes

Molecular Mechanisms of Human Pancreatic Islet Dysfunction Under Overnutrition Metabolic Stress. [Abstract]

2025 Oct 1;74(10):1825-1838. PMID: 40773375
Cell Death Discov

SMYD2 aggravates gastrointestinal stromal tumor via upregulation of EZH2 and downregulation of TET1. [Abstract]

2022 Jun 6;8(1):274. PMID: 35668081
Cells

SMYD2 Inhibition Downregulates TMPRSS2 and Decreases SARS-CoV-2 Infection in Human Intestinal and Airway Epithelial Cells. [Abstract]

2022 Apr 8;11(8):1262. PMID: 35455942
Development

The Gridlock transcriptional repressor impedes vertebrate heart regeneration by restricting expression of lysine methyltransferase. [Abstract]

2020 Sep 28;147(18):dev190678. PMID: 32988975
Endocrinology

Bisphenol A and Phthalates Modulate Peritoneal Macrophage Function in Female Mice Involving SYMD2-H3K36 Dimethylation. [Abstract]

2018 May 1;159(5):2216-2228. PMID: 29718165
Research Square Preprint

2024 Nov 13.
Research Square Print

September 20th, 2022.

Solvant et solubilité

In Vitro:

DMSO : 15 mg/mL (26.10 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.7399 mL

8.6993 mL

17.3986 mL

5 mM

0.3480 mL

1.7399 mL

3.4797 mL

10 mM

0.1740 mL

0.8699 mL

1.7399 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.5 mg/mL (4.35 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (4.35 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (279 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
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- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Nguyen H, et al. LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2. J Biol Chem. 2015 May 29;290(22):13641-13653. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.7399 mL	8.6993 mL	17.3986 mL	43.4964 mL
	5 mM	0.3480 mL	1.7399 mL	3.4797 mL	8.6993 mL
	10 mM	0.1740 mL	0.8699 mL	1.7399 mL	4.3496 mL
	15 mM	0.1160 mL	0.5800 mL	1.1599 mL	2.8998 mL
	20 mM	0.0870 mL	0.4350 mL	0.8699 mL	2.1748 mL
	25 mM	0.0696 mL	0.3480 mL	0.6959 mL	1.7399 mL

Keywords

LLY-507

11 Cited Publications

100 mg Obtenir un devis

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LLY-507

Epigenetics Compound Library

Histone Modification Research Compound Library

Anti-Cancer Compound Library

Reprogramming Compound Library

Chemical Probe Library

Anti-Breast Cancer Compound Library

Anti-Blood Cancer Compound Library

Targeted Diversity Library

Heterocyclic Compound Library

Highly Selective Inhibitors Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

Epigenetics Compound Library Mini

MCE Bioactive Compound Library

Bioactive Compound Library

Methylation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Publications Citing Use of MedChemExpress (MCE) LLY-507

Voir tous les produits spécifiques à Isoform Histone Methyltransferase

Activité biologique

Chemical Information

Publications (11)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

LLY-507

Epigenetics Compound Library

Histone Modification Research Compound Library

Anti-Cancer Compound Library

Reprogramming Compound Library

Chemical Probe Library

Anti-Breast Cancer Compound Library

Anti-Blood Cancer Compound Library

Targeted Diversity Library

Heterocyclic Compound Library

Highly Selective Inhibitors Library

Anti-Hematopathy Compound Library

Bioactive Compound Library Max

Epigenetics Compound Library Mini

MCE Bioactive Compound Library

Bioactive Compound Library

Methylation Compound Library

High-Throughput Bioactive Compound Library

Posttranslational Modification Library

Publications Citing Use of MedChemExpress (MCE) LLY-507

Voir tous les produits spécifiques à Isoform Histone Methyltransferase

Activité biologique

Chemical Information

Publications (11)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

LLY-507 Related Classifications

HY-19313 Related Classifications