Cat. No.: HY-B0509A

Amikacin

(Synonyms: BAY 41-6551)

26 Cited Publications

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Based on 26 publication(s) in Google Scholar

Amikacin (BAY 41-6551) is a semisynthetic kanamycin analog that is active against most Gram-negative bacteria, including gentamicin- and tobramycin-resistant strains. Significant inhibitory effect. Amikacin is ototoxic and nephrotoxic. Amikacin can be used in bacteriostatic, anti-cancer and analgesic studies.

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Pureté: 99.92%
CAS No.: 37517-28-5
Formule: C₂₂H₄₃N₅O₁₃
Masse moléculaire:585.60

Stockage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Amikacin Chemical Structure

CAS No.: 37517-28-5

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Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (26)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Bioz

Activité biologique

Description

IC₅₀ & Target

Aminoglycoside

TXNIP

Voir tous les produits spécifiques à Isoform Antibiotic :

Cellular Effect

Cell Line	Type	Value	Description	References
BMDM	CC₅₀	>90 μg/mL Compound: AMK	Cytotoxicity against mouse BMDM cells Cytotoxicity against mouse BMDM cells	[PMID: 35307568]
Vero	IC₅₀	>6.25 μg/mL Compound: Amikacin	Cytotoxicity against monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay Cytotoxicity against monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 28552337]
Vero	IC₅₀	>62.5 μg/mL Compound: Amikacin	Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay	[PMID: 23352268]

In Vitro

Amikacin (30 µg, 0-24 h) has antibacterial activity, with a MIC₅₀ value of 512 µg/mL against clinically isolated E. coli, and has a synergistic effect with imipenem (HY-B1369A), and the antibacterial effect is better when used in combination^[1].
Amikacin (250 µg/mL, 0-24 h) inhibits the migration and invasion of human breast cancer cell line MDA-MB-231 cells by up-regulating the expression of TXNIP, indicating its anti-tumor potential^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

human breast cancer cell line MDA-MB-231 cells
Concentration:

250 µg/mL
Incubation Time:

0-24 h
Result:

Upregulated the expression of TXNIP to 4.87 times.

In Vivo

Amikacin (single 30 mg/kg, s.c. or i.p.) has an analgesic effect in mice and has a synergistic effect when combined with morphine, but the analgesic effect of Amikacin can be reversed by Naloxone (HY-17417A)^[3].
Amikacin (500 mg/kg/day for 8 days, s.c.) damages calpain activity in rat cochlea, promotes the degradation of sensory cells and neurons, and then leads to ototoxicity^[4].
Amikacin (100 and 500 mg/kg/day for 10 days, s.c.) is nephrotoxic and its continued accumulation in rats can lead to kidney damage^[5].

Pharmacokinetic Analysis in SD rats^[5]

Route	Dose (mg/kg)	K_a (h^-1)	K_e1 (h^-1)	t_1/2 (h)	V (liter/kg)	AUC_0-∞ (mg·h/mL)
s.c.	100	1.20	6.77	0.10	0.28	53.0
s.c.	500	1.40	1.39	0.50	0.55	649.7

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 37517-28-5
Appearance Solid
Masse moléculaire 585.60
Formule C₂₂H₄₃N₅O₁₃
Color White to off-white
SMILES

O[C@@H]1[C@H]([C@@H](C[C@H](N)[C@H]1O[C@@]([C@@H]([C@@H](O)[C@@H]2O)O)([H])O[C@@H]2CN)NC([C@@H](O)CCN)=O)O[C@@]([C@@H]([C@@H](N)[C@@H]3O)O)([H])O[C@@H]3CO
Synonyms

BAY 41-6551
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (26)

All Microbiological Assay

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Journal Impact Factor

Signal Transduct Target Ther

Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]

2025 Dec 15;10(1):406. PMID: 41392286
Nat Commun

Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China. [Abstract]

2022 Mar 2;13(1):1116. PMID: 35236849
EBioMedicine

Diverse impacts of different rpoB mutations on the anti-tuberculosis efficacy of capreomycin. [Abstract]

2025 May 30:117:105776. PMID: 40449326
J Exp Med

Antibiotic use in early life impairs MAIT cell-mediated immunity in adulthood. [Abstract]

2026 Mar 2;223(3):e20241287. PMID: 41400657
J Clin Microbiol

Luciferase reporter mycobacteriophage (TM4:: GeNL) enables rapid assessment of drug susceptibilities and inducible macrolide resistance in Mycobacterium abscessus complex. [Abstract]

2025 Aug 20:e0084125. PMID: 40833127
Commun Biol

The acetyltransferase CysE modulates virulence and drug resistance of Mycobacterium tuberculosis by interfering with oxidative stress responses. [Abstract]

2025 Oct 6;8(1):1425. PMID: 41053365
Int J Antimicrob Agents

Elucidating adaptive compensatory tigecycline resistance mechanisms of RamA, RarA and SoxS in Klebsiella pneumoniae. [Abstract]

2025 Jun 9:107551. PMID: 40499596
Antibiotics (Basel)

Rapid Detection of Multiple Classes of β-Lactam Antibiotics in Blood Using an NDM-1 Biosensing Assay. [Abstract]

2021 Sep 14;10(9):1110. PMID: 34572692
Int J Antimicrob Agents

Activity of TP-6076 against carbapenem-resistant Acinetobacter baumannii isolates collected from inpatients in Greek hospitals. [Abstract]

2018 Aug;52(2):269-271. PMID: 29559273
Antimicrob Agents Chemother

An enoyl-ACP reductase inhibitor, NITD-916, expresses anti- Mycobacterium abscessus activity. [Abstract]

2025 May 23:e0024925. PMID: 40407337
Antimicrob Agents Chemother

TBAJ-587, a novel diarylquinoline, is active against Mycobacterium abscessus. [Abstract]

2024 Oct 29:e0094524. PMID: 39470202
Appl Microbiol Biotechnol

Anti-hepatitis C virus drug simeprevir: a promising antimicrobial agent against MRSA. [Abstract]

2022 Apr;106(7):2689-2702. PMID: 35338386
Microbiol Spectr

Antimicrobial resistance of rapidly growing mycobacteria isolated from companion animals in Taiwan. [Abstract]

2025 May 19:e0307424. PMID: 40387379
ACS Infect Dis

Lusutrombopag as a Repurposing Drug in Combination with Aminoglycosides against Vancomycin-Resistant Enterococcus. [Abstract]

2024 Apr 12;10(4):1327-1338. PMID: 38567846
ACS Chem Biol

Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents. [Abstract]

2022 Jan 21;17(1):39-53. PMID: 34908399
AMB Express

Repurposing pinaverium bromide against Staphylococcus and its biofilms with new mechanisms. [Abstract]

2024 Dec 24;14(1):141. PMID: 39718732

Amikacin purchased from MedChemExpress. Usage Cited in: AMB Express. 2024 Dec 24;14(1):141. [Abstract]

Combinational antimicrobial effects between PVB and conventional antibiotics against MRSA ATCC 43,300. TET, Tetracycline. DOX, Doxycycline. E, Erythromycin. AZI, Azithromycin. P, Penicillin. CAZ, Ceftazidime. AMP, Ampicillin. CEZ, Cefazolin. CEF, Cefotaxime. OXA, Oxacillin. CRO, Ceftriaxone. AMK, Amikacin. GEN, Gentamycin, KANA, Kanamycin. TOB, Tobramycin. SPC, Spectinomycin.
J Antimicrob Chemother

Evaluation of the in vitro activity of new polymyxin B analogue SPR206 against clinical MDR, colistin-resistant and tigecycline-resistant Gram-negative bacilli. [Abstract]

2020 Sep 1;75(9):2609-2615. PMID: 32591806
J Antimicrob Chemother

In vitro activity of the novel β-lactamase inhibitor taniborbactam (VNRX-5133), in combination with cefepime or meropenem, against MDR Gram-negative bacterial isolates from China. [Abstract]

2020 Jul 1;75(7):1850-1858. PMID: 32154866
Pathogens

N-Acetylcysteine as a Host-Directed Therapy Against Clarithromycin-Resistant Mycobacterium abscessus. [Abstract]

2025 Mar 21;14(4):302. PMID: 40333083
Eur J Clin Microbiol Infect Dis

Evaluation of EUCAST rapid antimicrobial susceptibility testing (RAST) for carbapenemase-producing Klebsiella pneumoniae with focus on KPC variants. [Abstract]

2025 Sep 29. PMID: 41023358
Eur J Clin Microbiol Infect Dis

Pharmacodynamic target attainment of the synergism of ceftazidime-avibactam in combination with amikacin against OXA-producing extensively drug-resistant or pan drug-resistant (XDR/PDR) Pseudomonas aeruginosa. [Abstract]

2025 Jun;44(6):1493-1500. PMID: 40056304
Curr Microbiol

Repurposing Sitafloxacin, Prulifloxacin, Tosufloxacin, and Sisomicin as Antimicrobials Against Biofilm and Persister Cells of Pseudomonas aeruginosa. [Abstract]

2021 Dec 14;79(1):12. PMID: 34905092
Int J Med Microbiol

Antibacterial and antibiofilm efficacy of repurposing drug hexestrol against methicillin-resistant Staphylococcus aureus. [Abstract]

2023 Mar 28;313(2):151578. PMID: 37001448
Authorea

2025 Sep 17.
bioRxiv

2025 May 30.
bioRxiv

2024 May 10.

Solvant et solubilité

In Vitro:

H₂O : 100 mg/mL (170.77 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.7077 mL

8.5383 mL

17.0765 mL

5 mM

0.3415 mL

1.7077 mL

3.4153 mL

10 mM

0.1708 mL

0.8538 mL

1.7077 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (283 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Farhan SM, et al. In Vitro and In Vivo Effect of Amikacin and Imipenem Combinations against Multidrug-Resistant E. coli. Trop Med Infect Dis. 2022 Oct 2;7(10):281. [Content Brief]

[2]. Wang YH, et al. Amikacin Suppresses Human Breast Cancer Cell MDA-MB-231 Migration and Invasion. Toxics. 2020 Nov 20;8(4):108. [Content Brief]

[3]. Atamer-Simsek S, et al. Antinociceptive effect of amikacin and its interaction with morphine and naloxone. Pharmacol Res. 2000 Mar;41(3):355-60. [Content Brief]

[4]. Ladrech S, et al. Calpain activity in the amikacin-damaged rat cochlea. J Comp Neurol. 2004 Sep 13;477(2):149-60. [Content Brief]

[5]. Chan K, et al. Characterization of Amikacin Drug Exposure and Nephrotoxicity in an Animal Model. Antimicrob Agents Chemother. 2020 Aug 20;64(9):e00859-20. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	1.7077 mL	8.5383 mL	17.0765 mL	42.6913 mL
	5 mM	0.3415 mL	1.7077 mL	3.4153 mL	8.5383 mL
	10 mM	0.1708 mL	0.8538 mL	1.7077 mL	4.2691 mL
	15 mM	0.1138 mL	0.5692 mL	1.1384 mL	2.8461 mL
	20 mM	0.0854 mL	0.4269 mL	0.8538 mL	2.1346 mL
	25 mM	0.0683 mL	0.3415 mL	0.6831 mL	1.7077 mL
	30 mM	0.0569 mL	0.2846 mL	0.5692 mL	1.4230 mL
	40 mM	0.0427 mL	0.2135 mL	0.4269 mL	1.0673 mL
	50 mM	0.0342 mL	0.1708 mL	0.3415 mL	0.8538 mL
	60 mM	0.0285 mL	0.1423 mL	0.2846 mL	0.7115 mL
	80 mM	0.0213 mL	0.1067 mL	0.2135 mL	0.5336 mL
	100 mM	0.0171 mL	0.0854 mL	0.1708 mL	0.4269 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Amikacin

26 Cited Publications

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Amikacin

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Publications Citing Use of MedChemExpress (MCE) Amikacin

Voir tous les produits spécifiques à Isoform Antibiotic

Activité biologique

Chemical Information

Publications (26)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Amikacin

Anti-Infection Compound Library

FDA-Approved Drug Library

Anti-Cancer Compound Library

Drug Repurposing Compound Library

Antibacterial Compound Library

FDA Approved & Pharmacopeial Drug Library

Antibiotics Library

Anti-Breast Cancer Compound Library

Rare Diseases Drug Library

Pediatric Drug Library

FDA-Approved Anticancer Drug Library

Human Metabolite Library

Off-patent Drug Library

Anti-Drug-Resistant Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

Protein Kinase Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Publications Citing Use of MedChemExpress (MCE) Amikacin

Voir tous les produits spécifiques à Isoform Antibiotic

Activité biologique

Chemical Information

Publications (26)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Amikacin Related Classifications

Cat. No.: HY-B0509A