Ergothioneine
Based on 13 publication(s) in Google Scholar
Ergothioneine is an imidazole-2-thione derivative with orally active histidine betaine. Ergothioneine is a specific inhibitor of p38-MAPK and Akt, which plays a protective role in cell apoptosis induced by stress. Ergothioneine has antioxidant activity.
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- Pureté: 99.98%
- CAS No.: 497-30-3
- Formule: C9H15N3O2S
- Masse moléculaire:229.30
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Stockage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Publications Citing Use of MedChemExpress (MCE) Ergothioneine
More- Redox Biol. 2026 Apr:91:104090. [Abstract]
- Mol Biomed. 2026 Jan 14;7(1):6. [Abstract]
- ACS Appl Mater Interfaces. 2024 Jun 12;16(23):29917-29929. [Abstract]
- ACS Appl Mater Interfaces. 2023 Apr 26;15(16):19833-19846. [Abstract]
- ACS Environ Au. 2025 Aug 5;5(6):573-582. [Abstract]
- Anal Chem. 2025 Jun 3;97(21):11099-11109. [Abstract]
- Antioxid Redox Signal. 2024 May 21. [Abstract]
- Int Immunopharmacol. 2023 Jun:119:110211. [Abstract]
- Sci Rep. 2026 Feb 28;16(1):11411. [Abstract]
- Hum Exp Toxicol. 2023 Jan-Dec:42:9603271231178015. [Abstract]
- SSRN. 2025 Nov 17.
- bioRxiv. 2025 June 02.
- bioRxiv. 2025 April 08.
Customer Validation & Images
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Cell Imaging/Staining
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Cell Proliferation/Viability Assay
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Flow Cytometry
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Apoptosis Analysis
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WB
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Activité biologique
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Microbial Metabolite |
Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
40 μM
Compound: 5351619
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Substrate uptake by the Organic Cation/Carnitine Transporter 1 (OCTN1, SLC22A4) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 cells stably transfected with SLC22A4
Substrate uptake by the Organic Cation/Carnitine Transporter 1 (OCTN1, SLC22A4) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 cells stably transfected with SLC22A4
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10.5281/zenodo.7360363 |
| HEK293 | EC50 |
40 μM
Compound: 5351619
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Substrate uptake by the Organic Cation/Carnitine Transporter 1 (OCTN1, SLC22A4) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 cells stably transfected with SLC22A4 (PubChem AID: 1794816)
Substrate uptake by the Organic Cation/Carnitine Transporter 1 (OCTN1, SLC22A4) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 cells stably transfected with SLC22A4 (PubChem AID: 1794816)
|
10.5281/zenodo.7360363 |
Ergothioneine (0.25, 1 mM, 23 h) can regulate PC12 DNA damage, MAPKs activation and cell death induced by hydrogen peroxide[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC12
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Concentration:0.25, 1 mM
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Incubation Time:23 h
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Result:Increased cell viability by approximately 13% and 34%, respectively.
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Cell Line:PC12
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Concentration:0.25, 1 mM
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Incubation Time:23 h
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Result:Counteracted the p38 phosphorylation induced by 1 h incubation with H2O2.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Cisplatin-treated rats[1]
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Dosage:70 mg/kg
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Administration:p.o. For 14 consecutive days
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Result:Decreased serum creatinine and BUN.
Increased GFR at two-fold.
Suppressed cisplatin-induced oxidative stress and GCT.
Up-regulated the levels of Nrf2, NQO1, and HO-1.
Suppresses NF-κB signaling and the pro-inflammatory cytokines.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 497-30-3
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Appearance Solid
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Masse moléculaire 229.30
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Formule C9H15N3O2S
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Color White to off-white
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SMILES
S=C1NC(C[C@@H](C([O-])=O)[N+](C)(C)C)=CN1
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Synonyms
L-(+)-Ergothioneine
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (13)
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Journal Impact Factor
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Most Recent
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Redox Biol
Ergothioneine rescues obesity-induced testicular dysfunction via dual restoration of steroidogenesis and mitochondrial redox homeostasis. [Abstract]2026 Apr:91:104090. PMID: 41719756 -
Mol Biomed
Ergothioneine attenuates whole-abdominal irradiation-induced multi-organ injury via the gut-heart-brain axis by modulating calcium voltage-gated channel subunit alpha1 C (Cacna1c) expression. [Abstract]2026 Jan 14;7(1):6. PMID: 41530565 -
ACS Appl Mater Interfaces
Ergothioneine-Sodium Hyaluronate Dressing: A Promising Approach for Protecting against Radiation-Induced Skin Injury. [Abstract]2024 Jun 12;16(23):29917-29929. PMID: 38813785
Ergothioneine purchased from MedChemExpress. Usage Cited in: ACS Appl Mater Interfaces. 2024 Jun 12;16(23):29917-29929. [Abstract]
Ergothioneine (EGT; 40 μg/mL; 48h). Fluorescence images of live/dead staining.
Ergothioneine purchased from MedChemExpress. Usage Cited in: ACS Appl Mater Interfaces. 2024 Jun 12;16(23):29917-29929. [Abstract]
Ergothioneine (EGT; 40 μg/mL; 0-6 days). Survival fraction at different radiation dosages by colony formation assay.
Ergothioneine purchased from MedChemExpress. Usage Cited in: ACS Appl Mater Interfaces. 2024 Jun 12;16(23):29917-29929. [Abstract]
Ergothioneine (EGT; 40 μg/mL; 24 h). Analysis of DCF fluorescence by flow cytometry.
Ergothioneine purchased from MedChemExpress. Usage Cited in: ACS Appl Mater Interfaces. 2024 Jun 12;16(23):29917-29929. [Abstract]
Ergothioneine (EGT; 40 μg/mL; 24 h). Statistics of apoptosis rate.
Ergothioneine purchased from MedChemExpress. Usage Cited in: ACS Appl Mater Interfaces. 2024 Jun 12;16(23):29917-29929. [Abstract]
Ergothioneine (EGT; 40 μg/mL; 24 h). Expression of Bcl-2, Bax, c-Caspase-3, and c-PARP following varying treatments.
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ACS Appl Mater Interfaces
Adhesive Ergothioneine Hyaluronate Gel Protects against Radiation Gastroenteritis by Alleviating Apoptosis, Inflammation, and Gut Microbiota Dysbiosis. [Abstract]2023 Apr 26;15(16):19833-19846. PMID: 37052616 -
ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
Antioxid Redox Signal
The antioxidant ergothioneine alleviates cisplatin-induced hearing loss through the Nrf2 pathway. [Abstract]2024 May 21. PMID: 38770822 -
Int Immunopharmacol
Ergothioneine inhibits the progression of osteoarthritis via the Sirt6/NF-κB axis both in vitro and in vivo. [Abstract]2023 Jun:119:110211. PMID: 37156032 -
Sci Rep
Ergothioneine promotes osteogenesis and angiogenesis through PI3K/AKT pathway and prevents glucocorticoid-induced osteonecrosis of the femoral head. [Abstract]2026 Feb 28;16(1):11411. PMID: 41764247 -
Hum Exp Toxicol
Anti-EMT properties of ergothioneine attenuate lipopolysaccharide-induced oxidative stress-mediated acute lung injury via modulating TGF-β/smad/snail signaling pathway. [Abstract]2023 Jan-Dec:42:9603271231178015. PMID: 37212426 -
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Solvant et solubilité
H2O : 125 mg/mL (545.14 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (436.11 mM); Clear solution; Need ultrasonic
Pureté et documentation
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Fiche technique (279 KB)
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SDS (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Colognato R, et al. Modulation of hydrogen peroxide-induced DNA damage, MAPKs activation and cell death in PC12 by ergothioneine. Clin Nutr. 2006 Feb;25(1):135-45. [Content Brief]
[2]. Salama SA, et al. Ergothioneine mitigates cisplatin-evoked nephrotoxicity via targeting Nrf2, NF-κB, and apoptotic signaling and inhibiting γ-glutamyl transpeptidase. Life Sci. 2021 Aug 1;278:119572. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.3611 mL | 21.8055 mL | 43.6110 mL | 109.0275 mL |
| 5 mM | 0.8722 mL | 4.3611 mL | 8.7222 mL | 21.8055 mL | |
| 10 mM | 0.4361 mL | 2.1805 mL | 4.3611 mL | 10.9027 mL | |
| 15 mM | 0.2907 mL | 1.4537 mL | 2.9074 mL | 7.2685 mL | |
| 20 mM | 0.2181 mL | 1.0903 mL | 2.1805 mL | 5.4514 mL | |
| 25 mM | 0.1744 mL | 0.8722 mL | 1.7444 mL | 4.3611 mL | |
| 30 mM | 0.1454 mL | 0.7268 mL | 1.4537 mL | 3.6342 mL | |
| 40 mM | 0.1090 mL | 0.5451 mL | 1.0903 mL | 2.7257 mL | |
| 50 mM | 0.0872 mL | 0.4361 mL | 0.8722 mL | 2.1805 mL | |
| 60 mM | 0.0727 mL | 0.3634 mL | 0.7268 mL | 1.8171 mL | |
| 80 mM | 0.0545 mL | 0.2726 mL | 0.5451 mL | 1.3628 mL | |
| 100 mM | 0.0436 mL | 0.2181 mL | 0.4361 mL | 1.0903 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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