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Harmine hydrochloride

(Synonyms: Telepathine hydrochloride)
29 Cited Publications
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Based on 29 publication(s) in Google Scholar

Harmine Hydrochloride (Telepathine Hydrochloride) is a natural DYRK inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM.

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  • Pureté: 99.98%
  • CAS No.: 343-27-1
  • Formule: C13H13ClN2O
  • Masse moléculaire:248.71
  • Stockage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Harmine hydrochloride Chemical Structure
    Harmine hydrochloride Chemical Structure
  • Experimental Validation Results for Harmine hydrochloride
  • Experimental Validation Results for Harmine hydrochloride
  • Experimental Validation Results for Harmine hydrochloride
  • Experimental Validation Results for Harmine hydrochloride
  • Experimental Validation Results for Harmine hydrochloride
  • Experimental Validation Results for Harmine hydrochloride
  • Experimental Validation Results for Harmine hydrochloride
  • Experimental Validation Results for Harmine hydrochloride
CAS No.: 343-27-1
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Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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  • Harmine hydrochloride Chemical Structure
    Harmine hydrochloride Chemical Structure
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    Harmine hydrochloride purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2024 Jul 18:e179472. [Abstract]

    Customer Validation
     Western blotting images showing the expression of ECM-related genes in primary human intestinal fibroblasts with or without TGF-β (5 ng/mL, 48 hours) and Harmine administration (5 μM or 10 μM, 48 hours).

  • 1/16

    Harmine hydrochloride purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2024 Jul 18:e179472. [Abstract]

    Customer Validation
     Masson’s trichrome staining showing collagen deposition in mouse colons across the 4 indicated groups. Twist1fl/fl mice and Col1a2-CreERT2Twist1fl/fl cohoused littermates (8 weeks old) were injected intraperitoneally with tamoxifen daily for 4 days (100 mg per kg body weight each time). The mice were subjected to 3 cycles of DSS administration (7 days of DSS administration followed by 14 days of regular drinking water). Harmine (10 mg/kg) was injected intraperitoneally twice a week during each DSS cycle (regularly on Tuesday and Friday weekly).

  • 1/16

    Harmine hydrochloride purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2024 Jul 18:e179472. [Abstract]

    Customer Validation
     Representative IF staining of mouse colons across the 4 indicated groups (original magnification, ×20). DAPI (blue), COL1A1 (red), and vimentin (green) in merged channels are shown. Twist1fl/fl mice and Col1a2-CreERT2Twist1fl/fl cohoused littermates (8 weeks old) were injected intraperitoneally with tamoxifen daily for 4 days (100 mg per kg body weight each time). The mice were subjected to 3 cycles of DSS administration (7 days of DSS administration followed by 14 days of regular drinking water). Harmine (10 mg/kg) was injected intraperitoneally twice a week during each DSS cycle (regularly on Tuesday and Friday weekly).

  • 1/16

    Harmine hydrochloride purchased from MedChemExpress. Usage Cited in: J Biomed Sci. 2022 Jun 2;29(1):34. [Abstract]

    Customer Validation
     HepG2 cells were incubated with Harmine (0, 2, 4, 8 μM) and were then cultured in the upper compartment of Transwell chambers for 24 h. Then, the cells were stained with crystal violet solution.

  • 1/16

    Harmine hydrochloride purchased from MedChemExpress. Usage Cited in: J Biomed Sci. 2022 Jun 2;29(1):34. [Abstract]

    Customer Validation
     Following treatment with Harmine (0, 5, 10, 20 μM) for 24 h at the indicated concentrations, total protein was extracted from HEPG2 and Hep3B cells and analysed by western blotting.

  • 1/16

    Harmine hydrochloride purchased from MedChemExpress. Usage Cited in: J Biomed Sci. 2022 Jun 2;29(1):34. [Abstract]

    Customer Validation
     HCC cells were serum-starved overnight, a scratch was created, and the cells were then incubated with 10 μM harmine and/or 10 ng/mL TGF-β for 6 h. Images were acquired under a microscope.

  • 1/16

    Harmine hydrochloride purchased from MedChemExpress. Usage Cited in: J Biomed Sci. 2022 Jun 2;29(1):34. [Abstract]

    Customer Validation
     Cells were serum-starved overnight and were then treated with Harmine (10 μM) or 10 ng/mL TGF-β for 6 h. Western blot analysis was then performed.

  • 1/16

    Harmine hydrochloride purchased from MedChemExpress. Usage Cited in: Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jun 15;79(Pt B):258-267. [Abstract]

    Customer Validation
     Representative images showing the restoration effect of Harmine on CUS-induced decrease in hippocampal DCX protein expressions. The Fluoxetine administration (20 mg/kg) is used as a positive control, and all data are shown as mean±SEM.

  • Harmine hydrochloride