Herpetin
Herpetin is an active lignan. Herpetin acts as a bone marrow mesenchymal stem cell inducer that activates the SDF-1/CXCR4 axis and the Wnt/β-catenin pathway. Herpetin is applicable to research related to acute liver injury.
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- CAS No.: 911052-87-4
- Formule: C30H34O9
- Masse moléculaire:538.59
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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CXCR4 |
Herpetin (10-100 μM; 24-72 h) reduces the viability of mouse bone marrow mesenchymal stem cells (BMSCs) in a concentration-dependent manner within the range of 25-100 μM, while 10 μM Herpetin exerts no significant cytotoxic effect on mouse BMSCs[1].
Herpetin (10 μM; 7-21 d) promotes the differentiation of mouse bone marrow mesenchymal stem cells (BMSCs) into hepatocyte-like cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:passage 3-5 mouse bone marrow mesenchymal stem cells (BMSCs)
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Concentration:10, 25, 50, 75, 100 μM
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Incubation Time:24, 48, 72 h
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Result:Significantly reduced BMSC viability at 25, 50, 75, 100 μM after 24, 48, and 72 h.
Showed no significant effect on BMSC viability at 10 μM across all tested time points.
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Cell Line:passage 3-5 mouse bone marrow mesenchymal stem cells (BMSCs)
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Concentration:10 μM
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Incubation Time:7, 14, 21 d
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Result:Significantly increased relative CYP3A4 fluorescence intensity compared to untreated BMSCs at 7, 14, and 21 d.
Significantly increased glycogen storage in BMSCs compared to untreated BMSCs at 14 and 21 d; no significant difference was observed at 7 d.
Increased alpha-fetoprotein (AFP), albumin (ALB), and cytokeratin 18 (CK18) expression compared to untreated BMSCs, with statistically significant increases at 14 and 21 d and non-significant increases at 7 d.
Peaked AFP expression at 14 d then decreased, while ALB and CK18 expression increased continuously from 7 to 21 d.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (male, 6-8 weeks of age)[1]
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Dosage:20 mg/kg
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Administration:i.p.; single dose (administered 8 hours post-liver injury induction)
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Result:Reduced serum AST levels compared to the model group.
Reduced the liver histopathological severity score compared to the model group.
Elevated liver tissue expression of SDF-1, CXCR4, p-GSK-3β, and β-catenin compared to the model group.
Improved mouse survival rate compared to the model group.
Chemical Information
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CAS No. 911052-87-4
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Masse moléculaire 538.59
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Formule C30H34O9
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SMILES
C(O)[C@H]1C=2C(O[C@@H]1C3=CC(OC)=C(O)C=C3)=CC(C[C@H]4[C@@H](CO)[C@@H](OC4)C5=CC(O)=C(OC)C=C5)=CC2OC
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Ding Y, et al. Herpetin Promotes Bone Marrow Mesenchymal Stem Cells to Alleviate Carbon Tetrachloride-Induced Acute Liver Injury in Mice. Molecules. 2023;28(9):3842. Published 2023 May 1. [Content Brief]
[2]. Cong LB, et al. Simultaneous determination of seven bioactive lignans in Herpetospermum caudigerum by RP-HPLC method. Biomed Chromatogr. 2008;22(10):1084-1090. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Herpetin Related Classifications
HY-N9858 Related Classifications
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- Herpetin
- 911052-87-4
- CXCR
- Wnt
- β-catenin
- SDF-1/CXCR4 axis
- bone marrow mesenchymal stem cells
- carbon tetrachloride-induced acute liver injury mice
- Wnt/β-catenin pathway
- Herpetospermum caudigerum Wall.
- albumin
- alpha-fetoprotein
- cytokeratin 18
- cytochrome P450 family 3 subfamily a member 4
- hepatocyte-like cells
- Inhibitor
- inhibitor
- inhibit