JP-2-196
JP-2-196 is a molecular glue that covalently targets the RING family E3 ligase RNF126. JP-2-196 also binds to RNF40, MID2, RNF219, RNF14, and LRSAM1. JP-2-196 induces the formation of ternary complexes between RNF126 and target proteins (e.g., BRD4, AR-V7), thereby promoting their ubiquitination and proteasomal degradation. JP-2-196 has potential for cancer research (such as prostate cancer and leukemia).
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- CAS No.: 2913587-30-9
- Formule: C15H18N2O3
- Masse moléculaire:274.32
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
JP-2-196 (0.1-50 μM) covalently binds recombinant RNF126 protein in a dose-dependent manner[1].
JP-2-196 (50 μM) competes with the JP-2-196-alkyne probe for the same binding site on recombinant RNF126[1].
JP-2-196 specifically binds to the zinc-binding site of RNF126 (1-40) or its vicinity, without altering the folding or stability of the protein[1].
JP-2-196 (24 h) alone does not induce degradation of either the long or short isoform of BRD4 in HEK293T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 2913587-30-9
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Masse moléculaire 274.32
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Formule C15H18N2O3
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SMILES
O=C(C=CC(=O)N1CCNCC1)C2=CC=C(OC)C=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Toriki ES, et al. Rational Chemical Design of Molecular Glue Degraders. ACS central science. 2023 May 24;9(5):915-926. [Content Brief]
[2]. Fu MJ, et al. Unleashing the Power of Covalent Drugs for Protein Degradation. Medicinal research reviews. 2025 Jul;45(4):1045-1076. [Content Brief]
[3]. Chang HR, et al. RNF126, 168 and CUL1: The Potential Utilization of Multi-Functional E3 Ubiquitin Ligases in Genome Maintenance for Cancer Therapy. Biomedicines. 2023 Sep 13;11(9):2527. [Content Brief]
[4]. Palaferri L, et al. Recent Advances in CBP/EP300 Degraders. Chimia. 2025 Mar 26;79(3):137-145.
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JP-2-196 Related Classifications
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