MS8847N2
MS8847N2 is a negative control analog of an EZH2 PROTAC degrader that binds EZH2 but does not bind the VHL E3 ligase or induce EZH2 degradation.
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- CAS No.: 3050872-64-2
- Formule: C70H98N10O8S
- Masse moléculaire:1239.65
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
MS8847N2 (0.03-0.3 μM; 24 h) does not degrade EZH2 or reduce H3K27me3 levels in EOL-1 MLL-rearranged acute myeloid leukemia cells after 24 h treatment at concentrations up to 0.3 μM[1].
MS8847N2 (0.03-0.3 μM; 24 h) does not degrade EZH2 in MV4;11 MLL-rearranged acute myeloid leukemia cells after 24 h treatment at concentrations up to 0.3 μM, with only minimal reduction of H3K27me3 levels[1].
MS8847N2 (5 days) does not inhibit cell growth in MV4;11 MLL-rearranged acute myeloid leukemia cells after 5 days of treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:EOL-1 MLL-rearranged acute myeloid leukemia cells
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Concentration:0.03, 0.1, 0.3 μM
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Incubation Time:24 h
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Result:Showed no degradation of EZH2 protein at any tested concentration.
Showed no reduction of H3K27me3 protein levels compared to DMSO control.
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Cell Line:MV4;11 MLL-rearranged acute myeloid leukemia cells
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Concentration:0.03, 0.1, 0.3 μM
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Incubation Time:24 h
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Result:Showed no degradation of EZH2 protein at any tested concentration.
Showed only minimal reduction of H3K27me3 protein levels compared to DMSO control.
Chemical Information
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CAS No. 3050872-64-2
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Masse moléculaire 1239.65
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Formule C70H98N10O8S
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SMILES
CCN(C1CCOCC1)C2=CC(C3=CC=C(C=C3)CN4CCN(CC4)CCC(NCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5[C@H](C[C@@H](C5)O)C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)=O)=O)=O)=CC(C(NCC8=C(C=C(NC8=O)C)C)=O)=C2C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MS8847N2 Related Classifications
HY-186272 Related Classifications
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