NCT-10b
NCT-10b is a selective HDAC6 inhibitor. NCT-10b mediates preferential α-tubulin acetylation without major histone H4 acetylation.NCT-10b can be used for the research of multiple myeloma.
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- CAS No.: 908860-09-3
- Formule: C21H38N2O4S
- Masse moléculaire:414.61
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
HDAC6 |
α-Tubulin |
In Vitro
NCT-10b (compound 17b) (0.1-300 μM; 8 h) selectively induces α-tubulin acetylation over histone H4 acetylation in HCT116 cells, with an EC50 of 0.23 μM for α-tubulin acetylation and a selectivity index >140[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116 cells
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Concentration:0.1; 0.3; 1; 3; 10; 30; 100; 300 μM
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Incubation Time:8 h
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Result:Produced a dose-dependent increase in acetylated α-tubulin without a major increase in acetylated histone H4.
Reached an EC50 value of 0.23 μM for α-tubulin acetylation, and an EC50 value of >32 μM for histone H4 acetylation, resulting in a selectivity index of >140.
Chemical Information
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CAS No. 908860-09-3
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Masse moléculaire 414.61
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Formule C21H38N2O4S
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SMILES
[C@H](C(NC1CCCC1)=O)(NC(OC(C)(C)C)=O)CCCCCSC(C(C)C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NCT-10b Related Classifications
HY-123699 Related Classifications
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