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Cat. No.: HY-177483

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OART

(Synonyms: Oxaliplatin-artesunate)

OART (Oxaliplatin-artesunate) is a ferroptosis inducer. OART significantly inhibits tumor cell proliferation. OART induces cytoplasmic and mitochondrial LPO to promote tumor ferroptosis, via destroying glutathione-mediated ferroptosis defense system and enhancing iron-dependent Fenton reaction. OART enhances tumor immunogenicity, transforming tumor environment from immunosuppressive to immunosensitive. OART has strong tumor regression in tumor-bearing mouse models. OART can be used for cancer immunotherapy research.

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Formule: C₂₇H₄₂N₂O₁₃Pt⁺
Masse moléculaire:797.71

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

OART Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Glutathione Peroxidase :

GPX1
GPX4

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Chemical Information

Masse moléculaire 797.71
Formule C₂₇H₄₂N₂O₁₃Pt⁺
SMILES

[OH-][Pt+4]12([O-]C(C([O-]2)=O)=O)(OC(CCC(O[C@@H]([C@@H]([C@@]3(CC[C@H]([C@@]4(CC5)[H])C)[H])C)O[C@](O[C@]65C)([C@]34OO6)[H])=O)=O)[NH2][C@@]7([H])[C@](CCCC7)([H])[NH2]1
Synonyms

Oxaliplatin-artesunate
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Fan R, et al. A platinum(IV)-artesunate complex triggers ferroptosis by boosting cytoplasmic and mitochondrial lipid peroxidation to enhance tumor immunotherapy. MedComm (2020). 2024 May 20;5(6):e570. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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OART

Voir tous les produits spécifiques à Isoform Glutathione Peroxidase

Voir tous les produits spécifiques à Isoform MMP