Cat. No.: HY-W062109

Olopatadine

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Olopatadine (ALO4943A; KW4679) is an orally active histamine H1 receptor antagonist and mast cell stabilizer. Olopatadine exerts antiallergic effects by blocking histamine H1 receptor-mediated activities. Olopatadine inhibits exocytosis, chemokine release, F-actin polymerization, CXCL10-induced calcium influx, and T cell chemotactic activity. Olopatadine also reduces the expression levels of CXCR3 on the surface of CD4⁺ and CD8⁺ T cells. Olopatadine inhibits scratching behavior, improves dermatitis scores, and suppresses intraepidermal neurite outgrowth. Olopatadine simultaneously decreases the levels of inflammatory markers, growth factors, histamine, and specific IgE, while increasing the expression of ErbB3A/HER3A. Olopatadine can be used in research related to seasonal pollinosis, chronic rhinitis, urticaria, allergic conjunctivitis, alopecia areata, and atopic dermatitis.

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Pureté: 98.94%
CAS No.: 113806-05-6
Formule: C₂₁H₂₃NO₃
Masse moléculaire:337.41

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4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Olopatadine Chemical Structure

CAS No.: 113806-05-6

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
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Description

IC₅₀ & Target^[1]

H₁ Receptor

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In Vitro

Olopatadine (1×10^-6-1×10^-5 M; 8 h) significantly inhibits the CXCL10-mediated chemotactic migration speed of CD4⁺ and CD8⁺ T cells isolated from patients with acute alopecia areata, with a stronger inhibitory effect at high concentrations than at low concentrations^[2].
Olopatadine (1×10^-6-1×10^-5 M) significantly reduces the CXCR3 expression level and F-actin polymerization on the surface of CD4⁺ and CD8⁺ T cells isolated from patients with acute alopecia areata^[2].
Olopatadine (1×10^-6-1×10^-5 M) significantly inhibits CXCL10-induced intracellular calcium influx in PBMCs isolated from one patient with acute alopecia areata, with a stronger inhibitory effect observed at the high concentration than at the low concentration^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Olopatadine (3-10 mg/kg/day; p.o.; daily; 14 days) administered orally to Dermatophagoides farinae body (Dfb)-induced atopic dermatitis NC/Nga mice significantly reduces scratching behavior, intraepidermal neurite outgrowth, skin inflammatory markers, and Dfb-specific IgE, with the 10 mg/kg/day dose additionally improving dermatitis scores, reducing epidermal thickness, increasing epidermal sema3A expression, and producing a higher scratching inhibition ratio (86.5%)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 113806-05-6
Appearance Solid
Masse moléculaire 337.41
Formule C₂₁H₂₃NO₃
Color White to off-white
SMILES

O=C(O)CC1=CC=C(C/2=C1)OCC3=CC=CC=C3C2=C\CCN(C)C
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
- Endogenous metabolite
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Baba A, et al. Olopatadine inhibits exocytosis in rat peritoneal mast cells by counteracting membrane surface deformation. Cell Physiol Biochem. 2015;35(1):386-396. [Content Brief]

[2]. Ito T, et al. Antihistaminic drug olopatadine downmodulates T cell chemotaxis toward CXCL10 by reducing CXCR3 expression, F-actin polymerization and calcium influx in patients with alopecia areata[J]. Journal of Dermatological Science, 2013, 72(1): 68-71.

[3]. Murota H, et al. Olopatadine hydrochloride improves dermatitis score and inhibits scratch behavior in NC/Nga mice. Int Arch Allergy Immunol. 2010;153(2):121-132. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Olopatadine

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Voir tous les produits spécifiques à Isoform Histamine Receptor

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Help & FAQs

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