UCN-02
Based on 1 Customer Validation
UCN-02 (7-epi-Hydroxystaurosporine) is a selective protein kinase C (PKC) inhibitor with a PKC IC50 value of 62 nM and a PKA IC50 value of 0.25 μM. UCN-02 can be produced by Streptomyces strain N-126. UCN-02 can be used for the research of breast carcinoma.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 95%
- CAS No.: 121569-61-7
- Formule: C28H26N4O4
- Masse moléculaire:482.53
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Stockage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
IC50: 62 nM (PKC), 250 nM (PKA)[2]
In Vitro
UCN-02 (0.25-0.37 μg/mL; 48-72 h) is produced by Streptomyces strain N-126[1].
UCN-02 inhibits purified protein kinase C (PKC) with an IC50 of 0.062 μM[2].
UCN-02 inhibits purified protein kinase A (PKA) with an IC50 of 0.25 μM[2].
UCN-02 (72 h) inhibits the growth of HeLa S3 cells[2].
UCN-02 (5-6 days) inhibits the growth of human breast carcinoma cell lines MDA-MB468 (IC50 = 100 nM), H85787 (IC50 = 20 nM), SK-BR-3 (IC50 = 200 nM), MDA-MB453 (IC50 = 350 nM), and MCF-7 (IC50 = 150 nM)[3].
UCN-02 (24 h-6 days) causes exposure-dependent growth inhibition in MDA-MB468 and MCF-7 human breast carcinoma cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 121569-61-7
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Appearance Liquid (Density: 1.63±0.1 g/cm3)
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Masse moléculaire 482.53
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Formule C28H26N4O4
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Color Colorless to light yellow
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SMILES
C[C@]12N3C4=C(C5=CC=CC=C53)C([C@@H](NC6=O)O)=C6C7=C4N([C@](C[C@H]([C@H]2OC)NC)([H])O1)C8=CC=CC=C78
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Synonyms
7-epi-Hydroxystaurosporine
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Structure Classification
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Initial Source
Streptomyces sp. N-126.
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (281 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Takahashi I, et al. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. I. Screening, producing organism and fermentation. J Antibiot (Tokyo). 1989 Apr;42(4):564-70. [Content Brief]
[2]. Takahashi I, et al. UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. J Antibiot (Tokyo). 1989 Apr;42(4):571-6. [Content Brief]
[3]. Seynaeve CM, et al. Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells. Cancer Res. 1993;53(9):2081-2086. [Content Brief]
[4]. Seynaeve CM, et al. Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue. Mol Pharmacol. 1994;45(6):1207-1214. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UCN-02 Related Classifications
HY-108262 Related Classifications
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