Art. -Nr.: HY-N7110

6-Hydroxyflavone

3 Cited Publications

Kundenbewertung

Based on 3 publication(s) in Google Scholar

6-Hydroxyflavone is an orally effective flavonoid compound. 6-Hydroxyflavone can inhibit LPS (HY-D1056) -induced NO production and has anti-inflammatory effects. 6-Hydroxyflavone promotes osteoblast differentiation by activating AKT, ERK 1/2 and JNK signaling pathways. 6-Hydroxyflavone has an inhibitory effect on bovine hemoglobin (BHb) glycosylation. 6-Hydroxyflavone has a kidney protective effect. In addition, 6-Hydroxyflavone enhances GABA-induced current through the Benzodiazepine sites of γ-aminobutyric acid (GABA_A) receptors. 6-Hydroxyflavone shows a clear preference for α2 - and α3 - subtypes, which play an anti-anxiety role.

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Reinheit: 99.92%
CAS. Nr.: 6665-83-4
Formel: C₁₅H₁₀O₃
Molecular Weight:238.24

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

6-Hydroxyflavone Chemical Structure

CAS. Nr.: 6665-83-4

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Akt Isoform-spezifische Produkte anzeigen :

Alle ERK Isoform-spezifische Produkte anzeigen :

Alle JNK Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
KB	ED₅₀	18 μg/mL Compound: NSC-26744	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 469554]

In Vitro

6-Hydroxyflavone (0-50 μM; 24 h) has no effect on MC3T3 cell viability^[2].
6-Hydroxyflavone (0-40 μM; 4 days-5 weeks) increases the activity of ALP and increases calcium deposition in MC3T3-E1 cells ^[2].
6-Hydroxyflavone (20 μM; 5-60 min) activates AKT, ERK 1/2 and JNK signaling pathways in MC3T3-E1 cells^[2].
6-Hydroxyflavone (0-200 μM; 48 h) shows high inhibitory activity on LPS (HY-D1056) -induced NO production in HBZY-1 cells (IC₅₀: 1.7 μM)^[3].
6-Hydroxyflavone (10 μM; 10 s) enhances GABA-induced current in cortical neurons through the Benzodiazepine sites of γ-aminobutyric acid (GABA_A) receptors and can be blocked by Flumazenil (HY-B0009), which has a high affinity for α2- and α3- subtype receptors in HEK 293T cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

MC3T3-E1 cells
Concentration:

20 μM
Incubation Time:

5, 10, 15, 30 and 60 min
Result:

Increased the phosphorylation levels of AKT, ERK 1/2 and JNK.

In Vivo

6-Hydroxyflavone (6-100 mg/kg; Oral administration; Single dose; 45 minutes before test) has anti-anxiety effect in mouse model^[4].
6-Hydroxyflavone (25-50 mg/kg; Intraperitoneal injection; 15 days) shows protective effect in Cisplatin (HY-17394) -induced nephrotoxicity rat model^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male ICR mice (20-36 g)^[4]
Dosage:

6, 12, 25, 50 and 100 mg/kg
Administration:

Oral administration (p.o.); Single dose; 45 minutes before test
Result:

Showed anti-anxiety effects on behavioral tests.

Animal Model:

Cisplatin (HY-17394) treated male Sprague-Dawley rats (200-250 g)^[5]
Dosage:

25 and 50 mg/kg
Administration:

Intraperitoneal injection (i.p.); 15 days
Result:

Significantly attenuated the Cisplatin associated detrimental changes in the body weight, and serum levels of creatinine and urea at both 25 mg/kg and 50 mg/kg.
Preserved the renal histoarchitecture from the toxicological influence of Cisplatin.
Reduced the Cisplatin-induced lipid peroxidation and corrected the renal antioxidant status.

Chemical Information

CAS. Nr. 6665-83-4
Appearance Solid
Molecular Weight 238.24
Formel C₁₅H₁₀O₃
Color Light yellow to yellow
SMILES

O=C1C=C(C2=CC=CC=C2)OC3=CC=C(O)C=C13
Structure Classification
- Flavonoids
- Flavones
- Phenols
- Monophenols
Initial Source
- Plants
- Labiatae
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (3)

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Journal Impact Factor

Food Chem

Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]

2025 Dec 30:497:146992. PMID: 41285060
Food Chem

Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]

2025 May 31:489:144992. PMID: 40466530
Phytomedicine

From virtual screening to functional discovery: Apigenin ameliorates acute pancreatitis by targeting HINT2 to regulate the mitochondrial acetylome. [Abstract]

2026 Mar:152:157826. PMID: 41579589

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (419.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.1974 mL

20.9872 mL

41.9745 mL

5 mM

0.8395 mL

4.1974 mL

8.3949 mL

10 mM

0.4197 mL

2.0987 mL

4.1974 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (8.73 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (8.73 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Das S, et al. Characterization of non-covalent binding of 6-hydroxyflavone and 5,7-dihydroxyflavone with bovine hemoglobin: Multi-spectroscopic and molecular docking analyses. J Photochem Photobiol B. 2018 Jan;178:40-52. [Content Brief]

[2]. Lai CH, et al. Effects of 6-Hydroxyflavone on Osteoblast Differentiation in MC3T3-E1 Cells. Evid Based Complement Alternat Med. 2014;2014:924560. [Content Brief]

[3]. Wang X, et al. 6-Hydroxyflavone and derivatives exhibit potent anti-inflammatory activity among mono-, di- and polyhydroxylated flavones in kidney mesangial cells. PLoS One. 2015 Mar 19;10(3):e0116409. [Content Brief]

[4]. Ren L, et al. GABA(A) receptor subtype selectivity underlying anxiolytic effect of 6-hydroxyflavone. Biochem Pharmacol. 2010 May 1;79(9):1337-44. [Content Brief]

[5]. Din ZU, et al. The flavonoid 6-hydroxyflavone prevention of cisplatin-induced nephrotoxicity. Histol Histopathol. 2020 Oct;35(10):1197-1209. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.1974 mL	20.9872 mL	41.9745 mL	104.9362 mL
	5 mM	0.8395 mL	4.1974 mL	8.3949 mL	20.9872 mL
	10 mM	0.4197 mL	2.0987 mL	4.1974 mL	10.4936 mL
	15 mM	0.2798 mL	1.3991 mL	2.7983 mL	6.9957 mL
	20 mM	0.2099 mL	1.0494 mL	2.0987 mL	5.2468 mL
	25 mM	0.1679 mL	0.8395 mL	1.6790 mL	4.1974 mL
	30 mM	0.1399 mL	0.6996 mL	1.3991 mL	3.4979 mL
	40 mM	0.1049 mL	0.5247 mL	1.0494 mL	2.6234 mL
	50 mM	0.0839 mL	0.4197 mL	0.8395 mL	2.0987 mL
	60 mM	0.0700 mL	0.3498 mL	0.6996 mL	1.7489 mL
	80 mM	0.0525 mL	0.2623 mL	0.5247 mL	1.3117 mL
	100 mM	0.0420 mL	0.2099 mL	0.4197 mL	1.0494 mL

Keywords

6-Hydroxyflavone

3 Cited Publications

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6-Hydroxyflavone

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Publications Citing Use of MedChemExpress (MCE) 6-Hydroxyflavone

Alle Akt Isoform-spezifische Produkte anzeigen

Alle ERK Isoform-spezifische Produkte anzeigen

Alle JNK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (3)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

6-Hydroxyflavone Related Classifications

HY-N7110 Related Classifications