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Art. -Nr.: HY-102000

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IACS-9571

(Synonyms: ASIS-P040)

1 Cited Publications

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IACS-9571 is a potent and selective inhibitor of TRIM24 and BRPF1, with IC₅₀ of 8 nM for TRIM24, and K_ds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.

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CAS. Nr.: 1800477-30-8
Formel: C₃₂H₄₂N₄O₈S
Molecular Weight:642.76

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

IACS-9571 Chemical Structure

CAS. Nr.: 1800477-30-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IACS-9571 is a potent and selective inhibitor of TRIM24 and BRPF1, with IC₅₀ of 8 nM for TRIM24, and K_ds of 31 nM and 14 nM for TRIM24 and BRPF1, respectively.

IC₅₀ & Target

IC50: 8 nM (TRIM24)^[1]
Kd: 31 nM (TRIM24), 14 nM (BRPF1)^[1]

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Cellular Effect

Cell Line	Type	Value	Description	References
CWR22R	IC₅₀	10.82 μM Compound: IACS-9571	Antiproliferative activity against human 22Rv1 cells measured after 96 hrs by Cell Titer-Glo assay Antiproliferative activity against human 22Rv1 cells measured after 96 hrs by Cell Titer-Glo assay	[PMID: 35385803]
HeLa	EC₅₀	0.05 μM Compound: 8i; IACS-9571	Inhibition of Flag-tagged TRIM24-PHD/bromodomain (unknown origin) expressed in human HeLa cells for 2 hrs by AlphaLisa assay Inhibition of Flag-tagged TRIM24-PHD/bromodomain (unknown origin) expressed in human HeLa cells for 2 hrs by AlphaLisa assay	[PMID: 26061247]
LNCaP	IC₅₀	12.15 μM Compound: IACS-9571	Antiproliferative activity against human LNCaP cells measured after 96 hrs by Cell Titer-Glo assay Antiproliferative activity against human LNCaP cells measured after 96 hrs by Cell Titer-Glo assay	[PMID: 35385803]
LNCaP C4-2B	IC₅₀	13.63 μM Compound: IACS-9571	Antiproliferative activity against human LNCaP C4-2B cells measured after 96 hrs by Cell Titer-Glo assay Antiproliferative activity against human LNCaP C4-2B cells measured after 96 hrs by Cell Titer-Glo assay	[PMID: 35385803]

In Vitro

IACS-9571 shows excellent cellular potency with EC₅₀ of 50 nM. IACS-9571 (1 μM) has potent activities against a panel of 32 bromodomains. IACS-9571 is a selective dual TRIM24/BRPF1 inhibitor (K_d = 1.3/2.1 nM) with 9- and 21-fold selectivity against BRPF2 and BRPF3, respectively. IACS-9571 does not interact with the BET sub-family of bromodomains, displaying greater than 7,700-fold selectivity versus BRD4(1, 2) relative to TRIM24^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1800477-30-8
Molecular Weight 642.76
Formel C₃₂H₄₂N₄O₈S
SMILES

O=S(C1=CC=C(OC)C(OC)=C1)(NC2=C(OC3=CC(OCCC)=CC(OCCCCN(C)C)=C3)C=C(N4C)C(N(C)C4=O)=C2)=O
Synonyms

ASIS-P040
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

Proc Natl Acad Sci U S A

TRIM24 as a therapeutic target in endocrine treatment-resistant breast cancer. [Abstract]

2025 Aug 19;122(33):e2507571122. PMID: 40815626

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Palmer WS, et al. Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J Med Chem. 2016 Feb 25;59(4):1440-54. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

IACS-9571

1 Cited Publications

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Reinheit & Dokumentation
Verweise

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IACS-9571

Publications Citing Use of MedChemExpress (MCE) IACS-9571

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Biologische Aktivität

Chemical Information

Publications (1)

Reinheit & Dokumentation

Verweise

Calculators

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IACS-9571 Related Classifications

HY-102000 Related Classifications