Art. -Nr.: HY-A0090

Nitrofurantoin

10 Cited Publications

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Based on 10 publication(s) in Google Scholar

Nitrofurantoin is a potent and orally active broad-spectrum beta-lactamase antimicrobial agent. Nitrofurantoin acts as an antibiotic and can be used for the study of urinary tract infections (UTIs), including cystitis and kidney infections.

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Reinheit: 99.71%
CAS. Nr.: 67-20-9
Formel: C₈H₆N₄O₅
Molecular Weight:238.16

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Nitrofurantoin Chemical Structure

CAS. Nr.: 67-20-9

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (10)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

β-lactam

Alle Antibiotic Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
5637	IC₅₀	21.3 μM Compound: NF	Cytotoxicity against human 5637 cells after 96 hrs by microtiter assay Cytotoxicity against human 5637 cells after 96 hrs by microtiter assay	[PMID: 18187237]
A-427	IC₅₀	1.86 μM Compound: NF	Cytotoxicity against human A427 cells after 96 hrs by microtiter assay Cytotoxicity against human A427 cells after 96 hrs by microtiter assay	[PMID: 18187237]
Caco-2	IC₅₀	0.115 μM Compound: NF	Anticancer activity against human Caco-2 cells incubated for 72 hrs by MTT assay Anticancer activity against human Caco-2 cells incubated for 72 hrs by MTT assay	[PMID: 36921275]
DAN-G	IC₅₀	6.74 μM Compound: NF	Cytotoxicity against human DAN-G cells after 96 hrs by microtiter assay Cytotoxicity against human DAN-G cells after 96 hrs by microtiter assay	[PMID: 18187237]
FHC	CC₅₀	>100 μM Compound: Nft	Cytotoxicity against human FHC cells assessed as reduction in cell viability incubated for 48 hrs by alamar blue assay Cytotoxicity against human FHC cells assessed as reduction in cell viability incubated for 48 hrs by alamar blue assay	[PMID: 33007545]
HeLa	IC₅₀	0.166 μM Compound: NF	Anticancer activity against human HeLa cells incubated for 72 hrs by MTT assay Anticancer activity against human HeLa cells incubated for 72 hrs by MTT assay	[PMID: 36921275]
KYSE-510	IC₅₀	29 μM Compound: NF	Cytotoxicity against human KYSE510 cells after 96 hrs by microtiter assay Cytotoxicity against human KYSE510 cells after 96 hrs by microtiter assay	[PMID: 18187237]
KYSE-70 cell line	IC₅₀	22.8 μM Compound: NF	Cytotoxicity against human KYSE70 cells after 96 hrs by microtiter assay Cytotoxicity against human KYSE70 cells after 96 hrs by microtiter assay	[PMID: 18187237]
LCLC-103H cell line	IC₅₀	2.34 μM Compound: NF	Cytotoxicity against human LCLC-103H cells after 96 hrs by microtiter assay Cytotoxicity against human LCLC-103H cells after 96 hrs by microtiter assay	[PMID: 18187237]
MCF7	IC₅₀	4.44 μM Compound: NF	Cytotoxicity against human MCF7 cells after 96 hrs by microtiter assay Cytotoxicity against human MCF7 cells after 96 hrs by microtiter assay	[PMID: 18187237]
RT-4	IC₅₀	7 μM Compound: NF	Cytotoxicity against human RT4 cells after 96 hrs by microtiter assay Cytotoxicity against human RT4 cells after 96 hrs by microtiter assay	[PMID: 18187237]
Sf21	IC₅₀	>1000 μM Compound: Nitrofurantoin	Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	[PMID: 21965623]
Sf21	IC₅₀	>1000 μM Compound: Nitrofurantoin	Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake	[PMID: 21965623]
SISO	IC₅₀	7.27 μM Compound: NF	Cytotoxicity against human SISO cells after 96 hrs by microtiter assay Cytotoxicity against human SISO cells after 96 hrs by microtiter assay	[PMID: 18187237]
THP-1	IC₅₀	>100 μM Compound: NFT	Cytotoxicity against human THP-1 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based assay Cytotoxicity against human THP-1 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based assay	[PMID: 36516584]
Vero	IC₅₀	0.9 nM Compound: Nitrofuradantoin	Anti-Herpes simplex virus type-1 activity in vero cells using plaque inhibition assay Anti-Herpes simplex virus type-1 activity in vero cells using plaque inhibition assay	[PMID: 10464017]
Vero	CC₅₀	23 μg/mL Compound: nitrofurantoin	Cytotoxicity against african green monkey Vero cells after 72 hrs by CellTiterGlo assay Cytotoxicity against african green monkey Vero cells after 72 hrs by CellTiterGlo assay	[PMID: 22691154]
Vero	IC₅₀	>100 μM Compound: NFT	Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based assay Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin dye based assay	[PMID: 36516584]
WI-38	IC₅₀	0.162 μM Compound: NF	Cytotoxicity in human WI-38 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity in human WI-38 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 36921275]

In Vitro

Nitrofurantoin (0-512 mg/L; 8 h) treatment inhibits the growth of E. coli isolates^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:

E. coli isolates: DA10708, DA13815, DA13824, DA13957, DA13992, DA10626, DA10627
Concentration:

0, 32, 64, 128, 256, and 512 mg/L
Incubation Time:

8 hours
Result:

Observed bactericidal effect at 32 mg/L For DA10708, DA13815 and DA13824.
Inhibited the growth of DA13957 and DA13992 completely at 128 mg/L, observed bactericidal effect at 256 mg/L.
Showed a moderate killing at >128 mg/L for DA10626 and DA10627.

In Vivo

1.19 Nitrofurantoin pharmacokinetic effects in SD Rats^[4].

Parameters	10 mg/kg p.o.	2 mg/kg i.v.
AUC_0-720 (μg/mL·min)	306
AUC_0-120 (μg/mL·min)		90.3
AUC_0-∞ (μg/mL·min)	344	91.5
C_max (μg/mL)	1.01
CL/F or CL (ml/min/kg)	31.0	22.7
t_1/2 (min)	166	23.6
Bioavailability (%)	60.1

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 67-20-9
Appearance Solid
Molecular Weight 238.16
Formel C₈H₆N₄O₅
Color Light yellow to yellow
SMILES

O=C1NC(CN1/N=C/C2=CC=C([N+]([O-])=O)O2)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (10)

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Journal Impact Factor

Nat Commun

Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China. [Abstract]

2022 Mar 2;13(1):1116. PMID: 35236849
Water Res

Quantifying community-wide antibiotic usage via urban water fingerprinting: Focus on contrasting resource settings in South Africa. [Abstract]

2023 Jul 15:240:120110. PMID: 37247434
J Exp Med

Antibiotic use in early life impairs MAIT cell-mediated immunity in adulthood. [Abstract]

2026 Mar 2;223(3):e20241287. PMID: 41400657
Microbiol Spectr

The Mechanism of Action of Ginkgolic Acid (15:1) against Gram-Positive Bacteria Involves Cross Talk with Iron Homeostasis. [Abstract]

2022 Feb 23;10(1):e0099121. PMID: 35019708
Biotechnol Bioeng

An integrated biomimetic array chip for establishment of collagen-based 3D primary human hepatocyte model for prediction of clinical drug-induced liver injury. [Abstract]

2021 Dec;118(12):4687-4698. PMID: 34478150
Diagn Microbiol Infect Dis

A rapid bacterial labeling method for phenotypic antimicrobial susceptibility testing. [Abstract]

2026 Feb;114(2):117181. PMID: 41205476
bioRxiv

2025 January 19.
bioRxiv

2024 May 10.
Research Square Preprint

2021 Aug.
Research Square Preprint

2020 Jun.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (419.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.1989 mL

20.9943 mL

41.9886 mL

5 mM

0.8398 mL

4.1989 mL

8.3977 mL

10 mM

0.4199 mL

2.0994 mL

4.1989 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Huttner A, et al. Nitrofurantoin revisited: a systematic review and meta-analysis of controlled trials. J Antimicrob Chemother. 2015 Sep;70(9):2456-64. [Content Brief]

[2]. Garau J. Other antimicrobials of interest in the era of extended-spectrum beta-lactamases: fosfomycin, nitrofurantoin and tigecycline. Clin Microbiol Infect. 2008 Jan;14 Suppl 1:198-202. [Content Brief]

[3]. Linus Sandegren, et al. Nitrofurantoin resistance mechanism and fitness cost in Escherichia coli. J Antimicrob Chemother. 2008 Sep;62(3):495-503. [Content Brief]

[4]. Xiaodong Wang, et al. Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2. Drug Metab Dispos. 2007 Feb;35(2):268-74. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.1989 mL	20.9943 mL	41.9886 mL	104.9714 mL
	5 mM	0.8398 mL	4.1989 mL	8.3977 mL	20.9943 mL
	10 mM	0.4199 mL	2.0994 mL	4.1989 mL	10.4971 mL
	15 mM	0.2799 mL	1.3996 mL	2.7992 mL	6.9981 mL
	20 mM	0.2099 mL	1.0497 mL	2.0994 mL	5.2486 mL
	25 mM	0.1680 mL	0.8398 mL	1.6795 mL	4.1989 mL
	30 mM	0.1400 mL	0.6998 mL	1.3996 mL	3.4990 mL
	40 mM	0.1050 mL	0.5249 mL	1.0497 mL	2.6243 mL
	50 mM	0.0840 mL	0.4199 mL	0.8398 mL	2.0994 mL
	60 mM	0.0700 mL	0.3499 mL	0.6998 mL	1.7495 mL
	80 mM	0.0525 mL	0.2624 mL	0.5249 mL	1.3121 mL
	100 mM	0.0420 mL	0.2099 mL	0.4199 mL	1.0497 mL

Keywords

Nitrofurantoin

10 Cited Publications

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Nitrofurantoin

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Publications Citing Use of MedChemExpress (MCE) Nitrofurantoin

Alle Antibiotic Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (10)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Nitrofurantoin

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

FDA-Approved Drug Library

Drug Repurposing Compound Library

Covalent Screening Library

Antibacterial Compound Library

NMPA-Approved Drug Library

Orally Active Compound Library

FDA Approved & Pharmacopeial Drug Library

Antibiotics Library

Drug-Induced Liver Injury (DILI) Compound Library

Rare Diseases Drug Library

Pediatric Drug Library

Human Metabolite Library

Anti-Prostate Cancer Compound Library

Heterocyclic Compound Library

Off-patent Drug Library

Mitochondrial Toxicity Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Covalent Screening Library Plus

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Publications Citing Use of MedChemExpress (MCE) Nitrofurantoin

Alle Antibiotic Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (10)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Nitrofurantoin Related Classifications

HY-A0090 Related Classifications