SAR7334
Based on 21 publication(s) in Google Scholar
SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 96.96%
- CAS. Nr.: 1333210-07-3
- Formel: C21H22ClN3O
- Molecular Weight:367.87
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) SAR7334
More- Cell Death Dis. 2020 Mar 5;11(3):170. [Abstract]
- Cell Death Dis. 2018 Oct 3;9(10):1015. [Abstract]
- Mol Ther. 2022 Apr 6;30(4):1754-1774. [Abstract]
- Virulence. 2025 Dec;16(1):2490208. [Abstract]
- Cells. 2020 Jan 14;9(1):202. [Abstract]
- Eur J Pharmacol. 2022 Oct 15:933:175254. [Abstract]
- J Mol Med (Berl). 2018 Jul;96(7):631-644. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2017 Sep;1863(9):2342-2354. [Abstract]
- Cell Calcium. 2019 Jan:77:8-19. [Abstract]
- J Physiol. 2025 Aug 28. [Abstract]
- J Physiol. 2024 Feb 10:10.1113/JP286118. [Abstract]
- FASEB J. 2022 Oct;36(10):e22527. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2017 Nov;1863(11):2964-2972. [Abstract]
- Exp Cell Res. 2022 Dec 1;421(1):113374. [Abstract]
- J Diabetes Res. 2020 Sep 16:2020:3634974. [Abstract]
- Food Chem Toxicol. 2019 Jul:129:281-290. [Abstract]
- Biochem Biophys Res Commun. 2025 Nov 1:787:152776. [Abstract]
- Heart Vessels. 2020 Dec;35(12):1755-1765. [Abstract]
- The Medical College of Wisconsin. 2025.
- bioRxiv. 2024 Dec 23:2024.12.23.629519. [Abstract]
- Research Square Preprint. 2024 Mar 28.
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Biologische Aktivität
IC50: 7.9 nM (TRPC6 currents)[3]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
282 nM
Compound: 52; SAR7334
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Inhibition of human TRPC3 expressed in CHO cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay
Inhibition of human TRPC3 expressed in CHO cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay
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[PMID: 30943030] |
| HEK293 | IC50 |
226 nM
Compound: 52; SAR7334
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Inhibition of human TRPC7 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay
Inhibition of human TRPC7 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay
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[PMID: 30943030] |
| HEK293 | IC50 |
7.9 nM
Compound: 52; SAR7334
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Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in TRPC6-induced current by Whole-cell patch-clamp
Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in TRPC6-induced current by Whole-cell patch-clamp
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[PMID: 30943030] |
| HEK293 | IC50 |
9.5 nM
Compound: 52; SAR7334
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Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay
Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay
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[PMID: 30943030] |
SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca2+ influx into cells with IC50s of 9.5, 282 and 226 nM[1][2][3], whereas TRPC4 and TRPC5-mediated Ca2+ entry is not affected. SAR7334 (1 μM) results in a major block of the Ang II-evoked calcium influx in the podocytes[1]. SAR7334 (1 μM) has negligible effect on SOCE[2]. SAR7334 dose-dependently reduces TRPC6 currents with an IC50 of 7.9 nM. SAR7334 (100 nM) substantially reduces TRPC6 currents[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1333210-07-3
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Appearance Solid
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Molecular Weight 367.87
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Formel C21H22ClN3O
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Color Light yellow to yellow
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SMILES
N[C@@H](C1)CCCN1[C@@H]2CC3=CC=CC=C3[C@H]2OC4=C(Cl)C=C(C#N)C=C4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (21)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
TRPC6-dependent Ca2+ signaling mediates airway inflammation in response to oxidative stress via ERK pathway. [Abstract]2020 Mar 5;11(3):170. PMID: 32139669 -
Cell Death Dis
Transient receptor potential channel 6 knockdown prevents apoptosis of renal tubular epithelial cells upon oxidative stress via autophagy activation. [Abstract]2018 Oct 3;9(10):1015. PMID: 30282964
SAR7334 purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Oct 3;9(10):1015. [Abstract]
HK-2 cells are treated with different concentrations of SAR7334 for 12 h. Representative western blot images and the relative quantification of LC3-II are shown.
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Mol Ther
2022 Apr 6;30(4):1754-1774. PMID: 35077860 -
Virulence
2025 Dec;16(1):2490208. PMID: 40202859 -
Cells
2020 Jan 14;9(1):202. PMID: 31947602 -
Eur J Pharmacol
Puerarin ameliorates myocardial remodeling of spontaneously hypertensive rats through inhibiting TRPC6-CaN-NFATc3 pathway. [Abstract]2022 Oct 15:933:175254. PMID: 36087696 -
J Mol Med (Berl)
2018 Jul;96(7):631-644. PMID: 29785489 -
Biochim Biophys Acta Mol Basis Dis
Changes in podocyte TRPC channels evoked by plasma and sera from patients with recurrent FSGS and by putative glomerular permeability factors. [Abstract]2017 Sep;1863(9):2342-2354. PMID: 28629718 -
Cell Calcium
Downregulation of TRPC6 expression is a critical molecular event during FK506 treatment for overactive bladder. [Abstract]2019 Jan:77:8-19. PMID: 30476735 -
J Physiol
GsMTx-4 inhibits the exercise pressor reflex and the muscle mechanoreflex primarily through TRPC inhibition. [Abstract]2025 Aug 28. PMID: 40876864 -
J Physiol
Inhibition and potentiation of the exercise pressor reflex by pharmacological modulation of TRPC6 in male rats. [Abstract]2024 Feb 10:10.1113/JP286118. PMID: 38340081 -
FASEB J
TRPC6 inhibits renal tubular epithelial cell pyroptosis through regulating zinc influx and alleviates renal ischemia-reperfusion injury. [Abstract]2022 Oct;36(10):e22527. PMID: 36036542 -
Biochim Biophys Acta Mol Basis Dis
An abnormal TRPV4-related cytosolic Ca2+ rise in response to uniaxial stretch in induced pluripotent stem cells-derived cardiomyocytes from dilated cardiomyopathy patients. [Abstract]2017 Nov;1863(11):2964-2972. PMID: 28754452 -
Exp Cell Res
Inhibition of TRPC6 suppressed TGFβ-induced fibroblast-myofibroblast transdifferentiation in renal interstitial NRK-49F cells. [Abstract]2022 Dec 1;421(1):113374. PMID: 36206825 -
J Diabetes Res
Protective Role of Tangshen Formula on the Progression of Renal Damage in db/db Mice by TRPC6/Talin1 Pathway in Podocytes. [Abstract]2020 Sep 16:2020:3634974. PMID: 33015191 -
Food Chem Toxicol
Activation of TRPC6 channels contributes to (+)-conocarpan-induced apoptotic cell death in HK-2 cells. [Abstract]2019 Jul:129:281-290. PMID: 31054997 -
Biochem Biophys Res Commun
Non-Ser36 phosphorylated p66Shc inhibits TRPC-dependent and TRPC-independent calcium influx in vascular smooth muscle cells. [Abstract]2025 Nov 1:787:152776. PMID: 41086682 -
Heart Vessels
TRPC6 participates in the development of blood pressure variability increase in sino-aortic denervated rats. [Abstract]2020 Dec;35(12):1755-1765. PMID: 32844288 -
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bioRxiv
Angiotensin II elicits robust calcium oscillations coordinated within juxtaglomerular cell clusters to suppress renin secretion. [Abstract]2024 Dec 23:2024.12.23.629519. PMID: 39763801 -
Lösungsmittel & Löslichkeit
DMSO : ≥ 370 mg/mL (1005.79 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Ilatovskaya DV, et al. The Role of Angiotensin II in Glomerular Volume Dynamics and Podocyte Calcium Handling. Sci Rep. 2017 Mar 22;7(1):299. [Content Brief]
[2]. Chauvet S, et al. Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain. Front Pharmacol. 2016 Dec 12;7:486. [Content Brief]
[3]. Maier T, et al. Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. Br J Pharmacol. 2015 Jul;172(14):3650-60. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7184 mL | 13.5918 mL | 27.1835 mL | 67.9588 mL |
| 5 mM | 0.5437 mL | 2.7184 mL | 5.4367 mL | 13.5918 mL | |
| 10 mM | 0.2718 mL | 1.3592 mL | 2.7184 mL | 6.7959 mL | |
| 15 mM | 0.1812 mL | 0.9061 mL | 1.8122 mL | 4.5306 mL | |
| 20 mM | 0.1359 mL | 0.6796 mL | 1.3592 mL | 3.3979 mL | |
| 25 mM | 0.1087 mL | 0.5437 mL | 1.0873 mL | 2.7184 mL | |
| 30 mM | 0.0906 mL | 0.4531 mL | 0.9061 mL | 2.2653 mL | |
| 40 mM | 0.0680 mL | 0.3398 mL | 0.6796 mL | 1.6990 mL | |
| 50 mM | 0.0544 mL | 0.2718 mL | 0.5437 mL | 1.3592 mL | |
| 60 mM | 0.0453 mL | 0.2265 mL | 0.4531 mL | 1.1326 mL | |
| 80 mM | 0.0340 mL | 0.1699 mL | 0.3398 mL | 0.8495 mL | |
| 100 mM | 0.0272 mL | 0.1359 mL | 0.2718 mL | 0.6796 mL |
SAR7334 Related Classifications
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