Art. -Nr.: HY-N6871

Abietic acid

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

Abietic acid, an orally active diterpene isolated from Colophony, displays significant anti-proliferative, anti-inflammatory, anti-obesity effect, bacteriostatic, cell cycle arresting and pro-apoptotic activities. Abietic acid inhibits lipoxygenase activity for allergy. Abietic acid enhances cell migration and tube formation in HUVECs. Abietic acid induces significant angiogenic potential, which is associated with upregulation of extracellular signal-regulated kinase (ERK) and p38 expression. Abietic acid attenuates sepsis-induced lung injury by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to inhibit M1 macrophage polarization. Abietic acid exhibits a positive effect against liver injury by attenuating inflammation and ferroptosis. Abietic acid shows accelerated wound closure in a mouse model of cutaneous wounds. Abietic acid significantly reduces the proliferation and growth of NSCLC cells by IKKβ inhibition.Additionally, Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice. Abietic acid is promising for research in non-small-cell lung cancer (NSCLC), liver injury-related deseases and psoriasis.

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Reinheit: 92.70%
CAS. Nr.: 514-10-3
Formel: C₂₀H₃₀O₂
Molecular Weight:302.45

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Abietic acid Chemical Structure

CAS. Nr.: 514-10-3

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle IKK Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>100 μM Compound: 1	Cytotoxic activity against human A549 cells assessed as reduction in cell viability after 72 hrs by SRB assay Cytotoxic activity against human A549 cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 28011223]
HeLa	CC₅₀	14.9 μg/mL Compound: 1	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 19217699]
PC-3	IC₅₀	>100 μM Compound: 1	Cytotoxic activity against human PC3 cells assessed as reduction in cell viability after 72 hrs by SRB assay Cytotoxic activity against human PC3 cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 28011223]
SK-OV-3	IC₅₀	90.4 μM Compound: 1	Cytotoxic activity against human SKOV3 cells assessed as reduction in cell viability after 72 hrs by SRB assay Cytotoxic activity against human SKOV3 cells assessed as reduction in cell viability after 72 hrs by SRB assay	[PMID: 28011223]
Vero	CC₅₀	52.5 μg/mL Compound: 1	Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay	[PMID: 19217699]

In Vitro

Abietic acid (0.8 μM, 24 h) inhibits the cell proliferation in in HUVECs, NSCLC and mouse macrophages, but increases tube formation, cell migration and the expression of p-p38 and p-ERK in HUVECs^[2]^[3]^[6].
Abietic acid (0-50 μM, 24h) effectively arrested the cells in the G0/G1 phase through reducing the expression of cell cycle-related proteins^[3].
Abietic acid (0-100 μM, 0.5 h or 1 h) binds directly to IKKβ and suppresses the IKKβ/NF-κB signaling pathway in NSCLC cells^[3].
The structure of hepatocytes in acetaminophen (APAP) (HY-66005) (300 mg/kg, i.p., 13 h) + abietic acid (10, 20, 40mg /kg, i.p., 13 h) group is similar to that in APAP group, the area of inflammatory infiltration and tissue necrosis is significantly reduced, and the nucleolus is obvious in the liver of mice^[5].
Abietic acid (20, 40, 80 μM, 13 h)significantly inhibits APAP-induced TNF-α, IL-1β expression and MDA and Fe²⁺ production, but significantly increases the expression of Nrf2 and HO-1 in liver cells^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

Human umbilical vein vascular endothelial cells (HUVECs)
Concentration:

0.4-25 μM
Incubation Time:

24 h
Result:

Inhibited the proliferation of HUVECs in a dose-dependent manner.

Cell Migration Assay ^[2]

Cell Line:

HUVECs
Concentration:

0.4 and 0.8 µM
Incubation Time:

24 h
Result:

Resulted in HUVECs migration increases of 9.23 and 25.17% at 0.4 and 0.8 µM.

Cell Cycle Analysis^[3]

Cell Line:

NSCLC cells
Concentration:

0-50 μM
Incubation Time:

24 h
Result:

Effectively arrested PC-9 and H1975 cells at the G0/G1 phase and down-regulated the expression of cyclin D1 and cdk4 in NSCLC cells.

Cell Viability Assay^[6]

Cell Line:

Mouse macrophages
Concentration:

low concentrations (20, 40 and 80 µmol/L) and high concentrations (160 and 320 µmol/L)
Incubation Time:

26 h
Result:

Decreased the viability of mouse macrophages at high concentrations and the concentration of IL-1β, TNF-α, IL-6 and MIP-2 which were induced by LPS in the cell culture medium of mouse macrophages.

In Vivo

Abietic acid (0.8 µM, daily for 10 days) exhibits accelerated wound healing in male ICR mouse model of cutaneous wounds^[2].
Abietic acid (40 mg/kg, i.p., 6 or 24 h) improved survival and attenuates sepsis induced lung injury in mice^[6].
Abietic acid (1.0 mg/kg, p.o., daily for 7 days) ameliorates the symptom of imiquimod (IMQ) (HY-B0180)-induced psoriasis-like inflammation and reconstructs the microbiota community composition in mice^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male ICR mouse model of cutaneous wounds (4-5 weeks of age)^[2]
Dosage:

0.8 µM
Administration:

treat wound daily, captured images on day 0, 2, 4, 6, 8, and 10
Result:

Had an effect on wound closure in male ICR mouse model of cutaneous wounds.

Animal Model:

Male C57BL/6 mice (24-30 g, 8-10 weeks old)^[6]
Dosage:

40 mg/kg
Administration:

i.p., 6 or 24 h
Result:

Improved survival and attenuated sepsis induced lung injury in mice.

Animal Model:

IMQ-induced psoriasis-like inflammation mice (7 weeks old, 16-18 g)
Dosage:

1.0 mg/kg
Administration:

p.o., daily for 7 days
Result:

Attenuated the imiquimod-induced psoriasis-like lesions and decreased PASI score of skin lesions in mice.

Chemical Information

CAS. Nr. 514-10-3
Appearance Solid
Molecular Weight 302.45
Formel C₂₀H₃₀O₂
Color White to off-white
SMILES

C[C@@]1(C2[C@@](CCC1)(C)[C@@]3([H])CCC(C(C)C)=CC3=CC2)C(O)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (3)

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Journal Impact Factor

Cell Rep

Carvedilol sensitizes chemotherapy by targeting STING to boost anti-tumor immunity. [Abstract]

2025 Apr 16;44(5):115572. PMID: 40249703
S Afr J Bot

2025 Sep.
Immunol Invest

NLRP12 Mediates Macrophage Polarization and Drives Host Defense Against Severe Klebsiella Pneumoniae Pneumonia. [Abstract]

2025 Oct 23:1-17. PMID: 41128475

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (330.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.3063 mL

16.5317 mL

33.0633 mL

5 mM

0.6613 mL

3.3063 mL

6.6127 mL

10 mM

0.3306 mL

1.6532 mL

3.3063 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (8.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
SDS (536 KB)
- English - EN (536 KB)
- Français - FR (536 KB)
- Deutsch - DE (536 KB)
- Norwegian - NO (536 KB)
- Español - ES (536 KB)
- Swedish - SV (536 KB)
- Italian - IT (536 KB)
- Korean - KR (536 KB)
- Portuguese - PT (536 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ulusu NN, et al. Abietic acid inhibits lipoxygenase activity. Phytother Res. 2002 Feb;16(1):88-90. [Content Brief]

[2]. Park JY, et al. Abietic acid isolated from pine resin (Resina Pini) enhances angiogenesis in HUVECs and accelerates cutaneous wound healing in mice[J]. J Ethnopharmacol. 2017 May 5;203:279-287. [Content Brief]

[3]. Liu X, et al. Abietic acid suppresses non-small-cell lung cancer cell growth via blocking IKKβ/NF-κB signaling[J]. Onco Targets Ther. 2019 Jun 20;12:4825-4837. [Content Brief]

[4]. Fernández MA, et al. Anti-inflammatory activity of abietic acid, a diterpene isolated from Pimenta racemosa var. grissea. J Pharm Pharmacol. 2001 Jun;53(6):867-72. [Content Brief]

[5]. An Y, et al. Abietic acid inhibits acetaminophen-induced liver injury by alleviating inflammation and ferroptosis through regulating Nrf2/HO-1 axis[J]. Int Immunopharmacol. 2023 May;118:110029. [Content Brief]

[6]. Fang H, et al. Abietic acid attenuates sepsis-induced lung injury by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to inhibit M1 macrophage polarization[J]. Exp Anim. 2022 Nov 10;71(4):481-490. [Content Brief]

[7]. Li XQ, et al. Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice[J]. J Ethnopharmacol. 2021 May 23;272:113934. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.3063 mL	16.5317 mL	33.0633 mL	82.6583 mL
	5 mM	0.6613 mL	3.3063 mL	6.6127 mL	16.5317 mL
	10 mM	0.3306 mL	1.6532 mL	3.3063 mL	8.2658 mL
	15 mM	0.2204 mL	1.1021 mL	2.2042 mL	5.5106 mL
	20 mM	0.1653 mL	0.8266 mL	1.6532 mL	4.1329 mL
	25 mM	0.1323 mL	0.6613 mL	1.3225 mL	3.3063 mL
	30 mM	0.1102 mL	0.5511 mL	1.1021 mL	2.7553 mL
	40 mM	0.0827 mL	0.4133 mL	0.8266 mL	2.0665 mL
	50 mM	0.0661 mL	0.3306 mL	0.6613 mL	1.6532 mL
	60 mM	0.0551 mL	0.2755 mL	0.5511 mL	1.3776 mL
	80 mM	0.0413 mL	0.2066 mL	0.4133 mL	1.0332 mL
	100 mM	0.0331 mL	0.1653 mL	0.3306 mL	0.8266 mL

Abietic acid

3 Cited Publications

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Abietic acid

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Publications Citing Use of MedChemExpress (MCE) Abietic acid

Alle IKK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (3)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Abietic acid Related Classifications

HY-N6871 Related Classifications