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Art. -Nr.: HY-183714

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Anticancer agent 325

Anticancer agent 325 is an apoptosis/autophagy inducer and anticancer agent. Anticancer agent 325 exhibits cytotoxic activity against gastric cancer cells, with no significant effect on healthy gastric epithelial cells. Anticancer agent 325 enhances the expression of activated/cleaved Caspase-3 to promote apoptosis. Anticancer agent 325 also enhances the cleavage of PARP, a downstream marker of apoptosis, promotes LC3B lipidation, and activates autophagy. Anticancer agent 325 can be used in the research of gastric cancer.

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CAS. Nr.: 2922798-57-8
Formel: C₁₈H₂₆O₅
Molecular Weight:322.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Anticancer agent 325 Chemical Structure

CAS. Nr.: 2922798-57-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

Caspase 3

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In Vitro

Anticancer agent 325 (compound 2d) (1.9-120.0 μM; 72 h) potently induces cytotoxicity in AGS and KATO III gastric cancer cells, with IC₅₀ values of 30.9 μM and 19.0 μM, respectively; by contrast, it shows a higher IC₅₀ value of 38.3 μM in non-malignant GES-1 gastric epithelial cells^[1].
Anticancer agent 325 (30 μM; 24 h) modulates apoptosis and autophagy markers in AGS and KATO III gastric cancer cells, but exerts no such effect on non-cancerous GES-1 gastric epithelial cells^[1].
Anticancer agent 325 (30 μM; 24 h) induces morphological changes of apoptosis and autophagosome formation in AGS gastric cancer cells, while it induces necrotic/apoptotic changes and autophagosome formation in KATO III gastric cancer cells, and also causes mitochondrial damage^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

human gastric adenocarcinoma AGS cells, human signet ring cell carcinoma KATO III cells, noncancerous gastric epithelial immortalized GES-1 cells
Concentration:

1.9, 3.8, 7.5, 15.0, 30.0, 60.0, 120.0 μM
Incubation Time:

72 h
Result:

Potently reduced viability of AGS cells with an IC₅₀ of 30.9 μM.
Potently reduced viability of KATO III cells with an IC₅₀ of 19.0 μM.
Reduced viability of GES-1 cells with an IC₅₀ of 38.3 μM.
Induced dose-dependent cytotoxicity, with significant reductions in cell viability at multiple concentrations relative to untreated controls.

Related Protocols :

Chemical Information

CAS. Nr. 2922798-57-8
Molecular Weight 322.40
Formel C₁₈H₂₆O₅
SMILES

OC1=CC=C(OC(C(CCCCC)CC(OC(C)C)=O)=O)C=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Olivieri D, et al. Synthesis and biological evaluation of mixed aryl-alkyl succinates as modulators of autophagy and apoptosis in gastric carcinoma. Bioorg Chem. Published online May 16, 2026. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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Anticancer agent 325

Alle Caspase Isoform-spezifische Produkte anzeigen