Balanophonin
Balanophonin is an anti-inflammatory and anti-cancer agent. Balanophonin inhibits microglial activation and neurodegeneration via inhibiting activated microglia-induced apoptosis.
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- CAS. Nr.: 80286-36-8
- Formel: C20H20O6
- Molecular Weight:356.37
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
COX-2 |
p38 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BV-2 | IC50 |
7.07 μM
Compound: 11
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Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
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[PMID: 26774654] |
| Hep 3B2 | IC50 |
31.5 μM
Compound: 1b
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Cytotoxicity against human Hep3B cells assessed as decrease in cell viability after 48 hrs by MTT assay
Cytotoxicity against human Hep3B cells assessed as decrease in cell viability after 48 hrs by MTT assay
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[PMID: 29567344] |
| HepG2 | IC50 |
38.7 μM
Compound: 1b
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Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as decrease in cell viability after 48 hrs by MTT assay
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[PMID: 29567344] |
In Vitro
Balanophonin (1-10 μM; 24 h) reduces Lipopolysaccharides (LPS; HY-D1056)-mediated TLR4 activation and NO production in BV2 cells[1].
Balanophonin (1-10 μM; 6 h) reduces iNOS and COX2 protein expression and TNF-α and IL-1β production in LPS-induced microglial cells[1].
Balanophonin (1-10 μM; 30 min) effectively inhibits MAPK activation[1].
Balanophonin (1-10 μM; 24 h) inhibits neuronal cell death resulting from LPS-activated microglia by regulating cleaved caspase-3 and poly ADP ribose polymerase (PARP) cleavage in N2a cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS-activated BV-2 cells
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Concentration:1, 5, and 10 μM
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Incubation Time:30 min for MAPKs, 6 h for iNOS and COX2 and 24 h for PGE2, TNF-α and IL-1β
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Result:Downregulated TLR4. Reduced iNOS and COX2 expression. Significantly reduced the secretion of TNF-α and IL-1β. Decreased the phosphorylation of MAPKs such as pERK, pJNK, and p-p38.
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Cell Line:Neuroblastoma N2a cells
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Concentration:1, 5, and 10 μM
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Incubation Time:24 h
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Result:Slightly increased Bcl-2. Inhibited caspase-3 activation and PARP cleavage.
Chemical Information
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CAS. Nr. 80286-36-8
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Molecular Weight 356.37
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Formel C20H20O6
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SMILES
OC[C@@H]1C2=CC(/C=C/C=O)=CC(OC)=C2O[C@H]1C3=CC(OC)=C(C=C3)O
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Balanophonin Related Classifications
HY-N10782 Related Classifications
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