Cathelicidin-PY
Cathelicidin-PY is an antimicrobial peptide exhibiting strong antimicrobial property. Cathelicidin-PY inhibits the activation of TLR4 inflammatory response pathways induced by lipopolysaccharide (LPS) (HY-D1056). Cathelicidin-PY possesses strong antimicrobial and anti-inflammatory activities and low cytotoxic ability against RAW 264.7 cells. Cathelicidin-PY can be used for antimicrobial and anti-inflammatory research.
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- CAS. Nr.: 1431866-92-0
- Formel: C151H263N47O39S2
- Molecular Weight:3425.13
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
In Vitro
Cathelicidin-PY exerts strong antimicrobial abilities against most of the tested microorganisms with MIC ranging from 4.69-37.5 μg/mL, and shows same antimicrobial activity against both clinically isolated drug-resistant and standard strains[1].
Cathelicidin-PY (2.5-20 μg/mL, 24 h) exerts anti-inflammatory activitiy by inhibiting the production of nitric oxide (NO) and inflammatory cytokines such as TNF-α, IL-6, and monocyte chemoattractant protein-1 (MCP-1)[1].
Cathelicidin-PY (5-20 μg/mL, 1 h) inhibits the LPS-induced TLR4 signaling pathway in RAW 264.7 murine macrophage cells by downregulating TLR4 expression, inhibiting JNK activation, and preventing NF-κB p65 nuclear translocation in a dose-dependent manner[1].
Cathelicidin-PY (1xMIC, 30 min) induces perturbation of the E. coli cell membrane, as evidenced by membrane breaks, outflow of cellular inclusions, and a vague cell boundary[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7 murine macrophage cells
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Concentration:0, 5, 10, and 20 μg/mL
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Incubation Time:1 h
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Result:Inhibited the expression of TLR4, JNK, and the translocation of NF-κB from cytoplasm to nucleus in a dose-dependent manner.
Inhibited 85% TLR4 expression and 74% NF-κB translocation induced by LPS (100 ng/mL, 3 h) at the concentration of 20 μg/mL, respectively.
Inhibited JNK expression induced by LPS.
Completely blocked LPS-induced JNK2 expression at 10 or 20 μg/mL.
Chemical Information
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CAS. Nr. 1431866-92-0
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Molecular Weight 3425.13
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Formel C151H263N47O39S2
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Sequence
Arg-Lys-Cys-Asn-Phe-Leu-Cys-Lys-Leu-Lys-Glu-Lys-Leu-Arg-Thr-Val-Ile-Thr-Ser-His-Ile-Asp-Lys-Val-Leu-Arg-Pro-Gln-Gly
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Sequence Shortening
RKCNFLCKLKEKLRTVITSHIDKVLRPQG
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Cathelicidin-PY Related Classifications
HY-P11183 Related Classifications
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