Ceftazidime-d5
Based on 1 Customer Validation
Ceftazidime-d5 (GR20263-d5) is the deuterium labeled Ceftazidime (HY-B0593). Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 90.05%
- Formel: C22H17D5N6O7S2
- Molecular Weight:551.61
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Speicherung:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 78439-06-2
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Appearance Solid
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Molecular Weight 551.61
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Formel C22H17D5N6O7S2
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Color White to off-white
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SMILES
[H][C@]1(N2C(C([O-])=O)=C(CS1)C[N+]3=C(C([2H])=C(C([2H])=C3[2H])[2H])[2H])[C@](NC(/C(C4=CSC(N)=N4)=N\OC(C)(C(O)=O)C)=O)(C2=O)[H]
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Synonyms
GR20263-d5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Lösungsmittel & Löslichkeit
H2O : 31.25 mg/mL (56.65 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (278 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Richards DM, et al. Ceftazidime. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1985 Feb;29(2):105-61. [Content Brief]
[2]. Esmat Kamali, et al. In vitro activities of cellulase and ceftazidime, alone and in combination against Pseudomonas aeruginosa biofilms. BMC Microbiol. 2021 Dec 16;21(1):347. [Content Brief]
[3]. Qiuxia Lin, et al. Avibactam potentiated the activity of both ceftazidime and aztreonam against S. maltophilia clinical isolates in vitro. BMC Microbiol. 2021 Feb 22;21(1):60. [Content Brief]
[4]. Shawn H MacVane, et al. Unexpected in vivo activity of ceftazidime alone and in combination with avibactam against New Delhi metallo-β-lactamase-producing Enterobacteriaceae in a murine thigh infection model. Antimicrob Agents Chemother. 2014 Nov;58(11):7007-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.8129 mL | 9.0644 mL | 18.1288 mL | 45.3219 mL |
| 5 mM | 0.3626 mL | 1.8129 mL | 3.6258 mL | 9.0644 mL | |
| 10 mM | 0.1813 mL | 0.9064 mL | 1.8129 mL | 4.5322 mL | |
| 15 mM | 0.1209 mL | 0.6043 mL | 1.2086 mL | 3.0215 mL | |
| 20 mM | 0.0906 mL | 0.4532 mL | 0.9064 mL | 2.2661 mL | |
| 25 mM | 0.0725 mL | 0.3626 mL | 0.7252 mL | 1.8129 mL | |
| 30 mM | 0.0604 mL | 0.3021 mL | 0.6043 mL | 1.5107 mL | |
| 40 mM | 0.0453 mL | 0.2266 mL | 0.4532 mL | 1.1330 mL | |
| 50 mM | 0.0363 mL | 0.1813 mL | 0.3626 mL | 0.9064 mL |
Ceftazidime-d5 Related Classifications
HY-B0593S Related Classifications
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