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Etidaligide

(Synonyms: DT01; coDbait)

Etidaligide, an AsiDNA, a first-in-class DNA repair inhibitor designed to prevent the repair of DNA damage in tumour cells. It also activates DNA-dependent protein kinase (DNA-PK) and poly (ADP-ribose) polymerase enzymes that induce phosphorylation of H2A

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  • Etidaligide Chemical Structure
    Etidaligide Chemical Structure
CAS. Nr.: 1974402-87-3
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  • Etidaligide Chemical Structure
    Etidaligide Chemical Structure DNA, d(G-sp-C-sp-T-sp-G-T-G-C-C-C-A-C-A-A-C-C-C-A-G-C-A-A-A-C-A-A-G-C-C-T-A-G-A[oxyphosphinicooxy(2-hydroxy-1,3-propanediyl)oxy-1,3-propanediylimino(1-oxo-1,11-undecanediyl)oxyphosphinicooxy]T-C-T-A-G-G-C-T-T-G-T-T-T-G-C-T-G-G-G-T-T-G-T-G-G-G-C-A-C-sp-A-sp-G-sp-C), 5'-[17-[(3β)-cholest-5-en-3-yloxy]-17-oxo-3,6,9,12-tetraoxa-16-azaheptadec-1-yl hydrogen phosphate]
    1/16
  • DNA, d(G-sp-C-sp-T-sp-G-T-G-C-C-C-A-C-A-A-C-C-C-A-G-C-A-A-A-C-A-A-G-C-C-T-A-G-A[oxyphosphinicooxy(2-hydroxy-1,3-propanediyl)oxy-1,3-propanediylimino(1-oxo-1,11-undecanediyl)oxyphosphinicooxy]T-C-T-A-G-G-C-T-T-G-T-T-T-G-C-T-G-G-G-T-T-G-T-G-G-G-C-A-C-sp-A-sp-G-sp-C), 5'-[17-[(3β)-cholest-5-en-3-yloxy]-17-oxo-3,6,9,12-tetraoxa-16-azaheptadec-1-yl hydrogen phosphate]