Il13 - interleukin 13 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116553

About Il13

Primary_assembly 10: 37,790,130-37,792,737 reverse strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 88 orthologues and is associated with 99 phenotypes. Restricted expression toward (RPKM 4.2).

Summary

Enables interleukin-13 receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of macromolecule metabolic process; and regulation of cation transmembrane transport. Located in extracellular space. Used to study asthma; extrinsic allergic alveolitis; and lipoid nephrosis. Biomarker of several diseases, including alcoholic hepatitis; middle cerebral artery infarction; peptic esophagitis; prostatic hypertrophy; and pulmonary fibrosis. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); diffuse scleroderma; lung disease (multiple); and nose disease (multiple). Orthologous to human IL13 (interleukin 13). [provided by Alliance of Genome Resources, Apr 2022]

Il13 Products (1)

mRNA Protein Name
NM_053828.1 NP_446280.1 interleukin-13 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables interleukin-13 receptor binding IPI
IPI: Inferred from physical interaction
11573960 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
18362439 RGD
involved in microglial cell activation IMP
IMP: Inferred from mutant phenotype
19752235 RGD
involved in negative regulation of NAD(P)H oxidase activity IMP
IMP: Inferred from mutant phenotype
19752235 RGD
involved in negative regulation of transforming growth factor beta production IDA
IDA: Inferred from direct assay
20100461 RGD
involved in positive regulation of B cell proliferation IDA
IDA: Inferred from direct assay
10331006 RGD
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
18941241 RGD
involved in positive regulation of immunoglobulin production IDA
IDA: Inferred from direct assay
11573960 RGD
involved in positive regulation of monoatomic ion transport IDA
IDA: Inferred from direct assay
11739109 RGD
involved in positive regulation of pancreatic stellate cell proliferation IDA
IDA: Inferred from direct assay
20100461 RGD
involved in positive regulation of protein secretion IDA
IDA: Inferred from direct assay
11739109 RGD
involved in positive regulation of release of sequestered calcium ion into cytosol IDA
IDA: Inferred from direct assay
20045483 RGD
involved in positive regulation of smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
20045483 RGD
involved in regulation of proton transport IDA
IDA: Inferred from direct assay
11739109 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
16698589 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
16522370 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
18490768 RGD
involved in response to nicotine IDA
IDA: Inferred from direct assay
18490768 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in extracellular space IDA
IDA: Inferred from direct assay
17429054 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il13 Protein Structure

IL13

IL13: pfam03487 (20 - 130)

  • 0
  • 100
  • 131 a.a.
Protein Preferred Names Protein Names

interleukin-13

  • IL-13

  • T-cell activation protein P600

Recombinant Il13 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P7099 IL-13 Protein, Rat P42203 (T19-H131) ≥ 98%, as determined by reducing SDS-PAGE.;≥ 98%, as determined by HPLC.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-B0539 Desloratadine 99.98% Yes
Inhibitory Antibodies (3)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-P9926 Dupilumab Inhibitor ≥99.2% Unkown
HY-P99025 Lebrikizumab Inhibitor 99.90% Unkown
HY-P99053 Tralokinumab Inhibitor 99.12% Unkown

Clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-154792 Pyrrolidone carboxylic acid / Phase 4
HY-155830 Morcamilast Inhibitor 98.92% Phase 2
HY-144683 PF-07038124 Inhibitor / Phase 2
Inhibitory Antibodies (17)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P990093 Stapokibart Inhibitor 99.37% Phase 4
HY-P990748 Lunsekimig Inhibitor 99.00% Phase 3
HY-P99496 Cendakimab Inhibitor 99.96% Phase 3
HY-P990090 Rademikibart Inhibitor 99.13% Phase 3
HY-P991515 TQH-2722 Inhibitor / Phase 3
HY-P99870 Eblasakimab ≥99.0% Phase 2
HY-P990741 Galvokimig 98.74% Phase 2
HY-P991266 SM-17 Inhibitor 96.98% Phase 2
HY-P99439 Anrukinzumab Inhibitor 98.64% Phase 2
HY-P991729 Zumilokibart Inhibitor 95.70% Phase 2
HY-P99883 Romilkimab Inhibitor 99.01% Phase 2
HY-P99846 Dectrekumab / Phase 2
HY-P990594 GSK-679586 Inhibitor / Phase 2
HY-P991633 TQC2938 Inhibitor / Phase 2
HY-P99417 Abrezekimab Inhibitor 95.00% Phase 1
HY-P991258 CNTO-5825 98.18% Phase 1
HY-P990602 IMA-026 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (45)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-126360 Oxazolone 98.0% Unkown
HY-P2797A Chitinase, Streptomyces griseus / Unkown
HY-N6013 Aloin (mixture of A&B) 99.36% Unkown
HY-P1848 Pep-1 (uncapped) 99.89% Unkown
HY-145551 Atinvicitinib Inhibitor 98.62% Unkown
HY-P2797 Chitinase, Serratia marcescens / Unkown
HY-144683A PF-07038124 hydrochloride Inhibitor 99.26% Unkown
HY-207120 TSLP-IN-1 Inhibitor 99.67% Unkown
HY-162248 JAK1/2-IN-1 Inhibitor 98.36% Unkown
HY-206870 BP79 Inhibitor / Unkown
HY-125019 iJak-381 Inhibitor 99.86% Unkown
HY-P11287A DOTA-Pep-1L TFA Ligand 98.60% Unkown
HY-110295 SPL-334 Inhibitor 99.6% Unkown
HY-158990 GE1111 95.73% Unkown
HY-181006 TSLP modulator-1 Inhibitor 99.61% Unkown
HY-P10292 NOTA-Pep-1L 98.60% Unkown
HY-P11147 IL13Rα2 D1 Inhibitor 99.17% Unkown
HY-144684 PDE4-IN-8 Inhibitor / Unkown
HY-165484 AVP-13358 Inhibitor / Unkown
HY-172806 PARP14 inhibitor 1 Inhibitor / Unkown
HY-175650 STAT6-IN-9 Inhibitor 98.11% Unkown
HY-175876 ADAM17-IN-1 Inhibitor / Unkown
HY-183548 XW-17 Ligand / Unkown
HY-184915 APH003 / Unkown
HY-P11122 MSP-1 P2 Activator / Unkown
HY-P11287 DOTA-Pep-1L Ligand / Unkown
HY-P2797B Chitinase / Unkown
HY-P2797C Chitinase,Trichoderma viride / Unkown
HY-RS06685 IL13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06686 Il13 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06687 Il13 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06688 IL13RA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06689 IL13RA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W109107 GED 0507-34-Levo / Unkown
HY-124613 Pyrazinib Inhibitor / Unkown
HY-174637 Human IL13RA2 mRNA / Unkown
HY-174638 Human IL13RA1 mRNA / Unkown
HY-174639 Human IL13 mRNA / Unkown
HY-187160 IL-4-IN-2 Inhibitor / Unkown
HY-N3989 Haplopine 99.49% Unkown
HY-N6013R Aloin (mixture of A&B) (Standard) / Unkown
HY-RS18438 Il13ra2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19279 Il13ra1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24920 Il13ra2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25769 Il13ra1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (9)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P990121 Anti-Mouse IL-4 Antibody (11B11) Inhibitor 97.67% Unkown
HY-P991162 Tilrekimig Inhibitor 97.00% Unkown
HY-P990735 Donzakimig 98.67% Unkown
HY-P990699 Riltovetbart 99% Unkown
HY-P991150 Ompekimig Inhibitor / Unkown
HY-P992034 APG808 Inhibitor 97.02% Unkown
HY-P992132 Solaprubart Inhibitor 99.59% Unkown
HY-P990442 Anti-IL-13 Antibody (CNTO 607) Inhibitor / Unkown
HY-P991594 Anti-IL-13 Antibody (C836) Inhibitor 97.20% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il13 NCBI NCBI:3596