PCNA - proliferating cell nuclear antigen Gene

Also Known as ATLD2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5111

About PCNA

Cytogenetic location: 20p12.3 Genomic coordinates (GRCh38): 20:5,114,953-5,126,622 (from NCBI)

This gene has 2 transcripts (splice variants), 235 orthologues and is associated with 2 phenotypes. Broad expression in bone marrow (RPKM 118.4), lymph node (RPKM 72.7) and 24 other tissues.

Summary

The protein encoded by this gene is found in the nucleus and is a cofactor of DNA Polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]

PCNA Products (2)

mRNA	Protein	Name
NM_002592.2	NP_002583.1	proliferating cell nuclear antigen
NM_182649.2	NP_872590.1	proliferating cell nuclear antigen

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA polymerase binding	IPI IPI: Inferred from physical interaction	19995904	GOA
enables MutLalpha complex binding	IDA IDA: Inferred from direct assay	11005803	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	23277426	GOA
enables damaged DNA binding	IDA IDA: Inferred from direct assay	24939902	GOA
enables dinucleotide insertion or deletion binding	IDA IDA: Inferred from direct assay	11005803	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	24115439	GOA
enables histone acetyltransferase binding	IPI IPI: Inferred from physical interaction	24939902	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	15681588	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8861913	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	11595739	GOA
enables purine-specific mismatch base pair DNA N-glycosylase activity	IDA IDA: Inferred from direct assay	11005803	GOA
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	17115032	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cellular response to UV	IDA IDA: Inferred from direct assay	24939902	GOA
involved in epithelial cell differentiation	IEP IEP: Inferred from expression pattern	21492153	GOA
involved in mismatch repair	IDA IDA: Inferred from direct assay	11005803	GOA
involved in positive regulation of DNA repair	IMP IMP: Inferred from mutant phenotype	24939902	GOA
involved in positive regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	24939902	GOA
involved in positive regulation of DNA-directed DNA polymerase activity	IMP IMP: Inferred from mutant phenotype	11595739	GOA
involved in positive regulation of deoxyribonuclease activity	IDA IDA: Inferred from direct assay	19443450	GOA
involved in translesion synthesis	IDA IDA: Inferred from direct assay	20129063	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of PCNA complex	IDA IDA: Inferred from direct assay	24939902	GOA
part of PCNA complex	IPI IPI: Inferred from physical interaction	15681588	GOA
part of PCNA-p21 complex	IDA IDA: Inferred from direct assay	11595739	GOA
located in centrosome	IDA IDA: Inferred from direct assay	18331714	GOA
located in chromatin	IDA IDA: Inferred from direct assay	23277426	GOA
located in nuclear replication fork	IDA IDA: Inferred from direct assay	15543136	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15494374	GOA
located in replication fork	IDA IDA: Inferred from direct assay	9774970	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCNA Protein Structure

PCNA_N

PCNA_C

0
100
200
261 a.a.

Protein Preferred Names	Protein Names
proliferating cell nuclear antigen	DNA polymerase delta auxiliary protein

PCNA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	PCNA	P12004	TMEM218	Homo sapiens	A2RU14	Y2H Array	29892012
Intra	PCNA	P12004	TMEM218	Homo sapiens	A2RU14	Y2H Array	25416956
Intra	PCNA	P12004	TMEM218	Homo sapiens	A2RU14	Y2H Prey Pooling	25416956
Intra	PCNA	P12004	CHAF1A	Homo sapiens	Q13111	Anti Bait CoIP	15805117
Intra	PCNA	P12004	CHAF1A	Homo sapiens	Q13111	Anti Tag CoIP	26496610
Intra	PCNA	P12004	SLC30A8	Homo sapiens	Q8IWU4	Validated Y2H	32296183
Intra	PCNA	P12004	HLTF	Homo sapiens	Q14527	Pull Down	18719106
Intra	PCNA	P12004	PCLAF	Homo sapiens	Q15004	Validated Y2H	32296183
Intra	PCNA	P12004	PCLAF	Homo sapiens	Q15004	Anti Tag CoIP	33961781
Intra	PCNA	P12004	PCLAF	Homo sapiens	Q15004	Anti Tag CoIP	26496610
Intra	PCNA	P12004	PCLAF	Homo sapiens	Q15004	Anti Tag CoIP	28514442
Intra	PCNA	P12004	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	PCNA	P12004	MSH3	Homo sapiens	P20585	Validated Y2H	25416956
Intra	PCNA	P12004	MSH3	Homo sapiens	P20585	Validated Y2H	32296183
Intra	PCNA	P12004	MSH3	Homo sapiens	P20585	Y2H Prey Pooling	25416956
Cross	PCNA	P12004	Gadd45g	Mus musculus	Q9Z111	Anti Tag CoIP	11022036
Cross	PCNA	P12004	Gadd45g	Mus musculus	Q9Z111	Y2H	11022036
Cross	PCNA	P12004	Gadd45g	Mus musculus	Q9Z111	Anti Bait CoIP	11022036
Intra	PCNA	P12004	NCR2	Homo sapiens	O95944	Pull Down	22021614
Intra	PCNA	P12004	NCR2	Homo sapiens	O95944	Affinity Chrom	22021614
Intra	PCNA	P12004	NCR2	Homo sapiens	O95944	FACS	22021614
Intra	PCNA	P12004	NCR2	Homo sapiens	O95944	SPR	22021614
Intra	PCNA	P12004	NCR2	Homo sapiens	O95944	ELISA	22021614
Intra	PCNA	P12004	SETD3	Homo sapiens	Q86TU7	BiFC	26030842
Intra	PCNA	P12004	SETD3	Homo sapiens	Q86TU7	Anti Bait CoIP	26030842
Intra	PCNA	P12004	GAPDH	Homo sapiens	P04406	IF	20849852
Intra	PCNA	P12004	POLD2	Homo sapiens	P49005	Anti Bait CoIP	16000169
Intra	PCNA	P12004	POLD2	Homo sapiens	P49005	Anti Tag CoIP	26496610
Intra	PCNA	P12004	POLD2	Homo sapiens	P49005	BiFC	26030842
Intra	PCNA	P12004	CDKN2A	Homo sapiens	P42771	Pull Down	17955473
Intra	PCNA	P12004	CDKN2A	Homo sapiens	P42771	IF	17955473
Intra	PCNA	P12004	CDKN2A	Homo sapiens	P42771	Anti Bait CoIP	17955473
Intra	PCNA	P12004	ING2	Homo sapiens	Q9H160	Anti Bait CoIP	19730436
Intra	PCNA	P12004	RNF7	Homo sapiens	Q9UBF6	Affinity Chrom	26030842
Intra	PCNA	P12004	RNF7	Homo sapiens	Q9UBF6	BiFC	26030842
Intra	PCNA	P12004	GADD45A	Homo sapiens	P24522	Lumier	37398436
Intra	PCNA	P12004	CDT1	Homo sapiens	Q9H211	Anti Bait CoIP	16482215
Intra	PCNA	P12004	NUTF2	Homo sapiens	P61970	Validated Y2H	32296183
Intra	PCNA	P12004	FEN1	Homo sapiens	P39748	Anti Tag CoIP	35271311
Intra	PCNA	P12004	FEN1	Homo sapiens	P39748	ITC	15576034
Intra	PCNA	P12004	FEN1	Homo sapiens	P39748	Y2H Array	18692475
Intra	PCNA	P12004	FEN1	Homo sapiens	P39748	FRET	14657243
Intra	PCNA	P12004	FEN1	Homo sapiens	P39748	X-Ray Diffraction	15576034
Intra	PCNA	P12004	FEN1	Homo sapiens	P39748	Anti Tag CoIP	26496610
Intra	PCNA	P12004	FEN1	Homo sapiens	P39748	Anti Tag CoIP	33961781
Intra	PCNA	P12004	PGK1	Homo sapiens	P00558	Far-WB	20849852
Intra	PCNA	P12004	PGK1	Homo sapiens	P00558	BiFC	26030842
Intra	PCNA	P12004	ALDOA	Homo sapiens	P04075	IF	20849852
Intra	PCNA	P12004	POLD1	Homo sapiens	P28340	Anti Tag CoIP	26496610
Intra	PCNA	P12004	POLD1	Homo sapiens	P28340	Far-WB	16510448
Intra	PCNA	P12004	POLD1	Homo sapiens	P28340	Anti Bait CoIP	15805117
Intra	PCNA	P12004	PGAM1	Homo sapiens	P18669	Far-WB	20849852
Intra	PCNA	P12004	MAF1	Homo sapiens	Q9H063	Affinity Chrom	26030842
Intra	PCNA	P12004	MAF1	Homo sapiens	Q9H063	Anti Bait CoIP	26030842
Intra	PCNA	P12004	MAF1	Homo sapiens	Q9H063	BiFC	26030842
Intra	PCNA	P12004	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	PCNA	P12004	POLD3	Homo sapiens	Q15054	Anti Tag CoIP	26496610
Intra	PCNA	P12004	POLD3	Homo sapiens	Q15054	FRET	16000169
Intra	PCNA	P12004	POLD3	Homo sapiens	Q15054	Confocal	16000169
Intra	PCNA	P12004	POLD3	Homo sapiens	Q15054	ITC	15576034
Intra	PCNA	P12004	POLD3	Homo sapiens	Q15054	X-Ray Diffraction	15576034
Intra	PCNA	P12004	POLD3	Homo sapiens	Q15054	Far-WB	16510448
Intra	PCNA	P12004	POLD4	Homo sapiens	Q9HCU8	ELISA	16510448
Intra	PCNA	P12004	POLD4	Homo sapiens	Q9HCU8	Far-WB	16510448

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PCNA Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P73729	PCNA Protein, Human (sf9, His)	P12004 (M1-S261)	≥ 90%, as determined by reducing SDS-PAGE.

PCNA Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80268	PCNA Antibody (YA241)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
HY-P84070	PCNA Antibody (YA3767)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Rabbit, Monkey
HY-P84070A	PCNA Antibody (YA3767)(PBS only)	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Rabbit, Monkey
HY-P86534	PCNA Antibody (YA6226)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86690	PCNA Antibody (YA6382)	WB, IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Ataxia-Telangiectasia-Like Disorder 2	ATLD2 Pcna-Related Progressive Neurodegenerative Photosensitivity Syndrome
Bowen'S Disease	Bowens Disease
Oral Leukoplakia	Leukoplakia Oral Leukoplakia, Oral
Leukoplakia	Leukoplakia Of Gingiva Leukoplakia Of Oral Epithelium Leucoplakia Of Oral Mucosa Leukokeratosis Of Oral Mucosa
Actinic Keratosis	Solar Keratosis Actinic Keratosis Senile Hyperkeratosis Sk - Solar Keratosis Keratosis, Actinic Seborrheic Keratosis Ak - [Actinic Keratosis] Sk - [Solar Keratosis]
Ovarian Mucinous Cystadenocarcinoma	Mucinous Cystadenocarcinoma Of Ovary
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Ataxia-Telangiectasia	Ataxia Telangiectasia Louis-Bar Syndrome AT At1 Ataxia-Telangiectasia Syndrome Ataxia - Telangiectasia Variant Boder-Sedgwick Syndrome Louis Bar Syndrome Cerebello-Oculocutaneous Telangiectasia Immunodeficiency With Ataxia Telangiectasia A-T Ataxia Telangiectasia Syndrome Atm Telangiectasia, Cerebello-Oculocutaneous Ataxia-Telangiectasia Variant
Mucoepidermoid Carcinoma	Mec Salivary Gland Mucoepidermoid Carcinoma C3772 Carcinoma Mucoepidermoid Carcinoma, Mucoepidermoid
Cortical Thymoma	Polygonal Cell Thymoma Thymoma, Cortical Thymoma, Type B2
Hydatidiform Mole, Recurrent, 1	Hydatidiform Mole Gestational Trophoblastic Disease Complete Hydatidiform Mole Hydm HYDM1 Chm Molar Pregnancy Hydatidiform Mole, Complete Hydatid Mole Complete Molar Pregnancy Mole, Hydatidiform, Recurrent, Type 1 Gestational Trophoblastic Neoplasms Hydatidiform Mole, Recurrent, 2 Classical Hydatidiform Mole
Ameloblastoma	Adenoameloblastoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Immunodeficiency 26	Severe Combined Immunodeficiency Due To Dna-Pkcs Deficiency Scid Due To Dna-Pkcs Deficiency Imd26 Immunodeficiency 26, With Or Without Neurologic Abnormalities
Laryngeal Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Larynx Squamous Cell Carcinoma Of Larynx Squamous Cell Carcinoma Of The Larynx Squamous Cell Carcinoma Of Head And Neck
Leiomyoma	Leiomyomatous Neoplasm Leiomyomatous Tumor Leiomyomas Fibroid Tumor Uterine Fibroids
Intracranial Meningioma	Meningioma
Odontoma
Oligodendroglioma	Oligodendroglial Neoplasm Oligodendroglial Tumor Oligodendroglial Tumors Well Differentiated Oligodendroglioma
Retinal Ischemia
Transitional Cell Carcinoma	Transitional Cell Neoplasm Carcinoma, Transitional Cell Transitional Carcinoma Transitional Cell Tumor Urothelial Cell Carcinoma Carcinoma Transitional Cell Transitional Cell Carcinoma Of Bladder
Papilloma	Papillomatosis
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Common Wart	Verruca Vulgaris Viral Warts Nos Filiform Warts Digitate Warts
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Adenoid Cystic Carcinoma	Adenocystic Carcinoma Cribriform Carcinoma Cylindroma Carcinoma Adenoid Cystic Carcinoma, Adenoid Cystic Adenoid Cystic Carcinoma Of Salivary Gland Eccrine Dermal Cylindroma Carcinoma, Cribriform
Benign Meningioma	Meningioma, Benign
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Fibrillary Astrocytoma	Fibrillary Astrocytic Tumors Diffuse Astrocytoma Gemistocytic Astrocytoma Protoplasmic Astrocytoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Dendritic Cell Thymoma	Epithelioid Thymoma Type B Thymoma
Gastrointestinal Carcinoma	Gastrointestinal Neoplasms
Breast Disease	Breast Diseases
Neuroma
Cystadenocarcinoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-N0095	(S)-10-Hydroxycamptothecin		99.74%	Phase 2
HY-160700	TNG348	Inhibitor	99.74%	Phase 2

Pre-clinical Phase

Bioactive Molecules (29)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-N0692	Schisandrol B		99.92%	Unkown
HY-NP199	Bovine pituitary extract	Modulator	/	Unkown
HY-110111	T2AA		99.04%	Unkown
HY-P4322	H-Ile-Lys-Val-Ala-Val-OH	Activator	99.35%	Unkown
HY-120836	AOH1160		98.56%	Unkown
HY-153365	I-138	Inhibitor	99.75%	Unkown
HY-17522	Meptyldinocap		99.91%	Unkown
HY-124012	PCNA-I1		98.78%	Unkown
HY-B1866	Linuron	Antagonist	99.88%	Unkown
HY-13338	Mabuterol	Agonist	99.96%	Unkown
HY-200129	PCNA-IN-1	Inhibitor	98.30%	Unkown
HY-125576	Griselimycin	Inhibitor	98.3%	Unkown
HY-117171	Proquinazid		/	Unkown
HY-123715	Anticancer agent 255		/	Unkown
HY-163691	Antitumor agent-163	Inhibitor	/	Unkown
HY-180216	USP1-IN-15	Inhibitor	/	Unkown
HY-180585	LOXL2/sGC modulator-2		/	Unkown
HY-183363	USP1-IN-17	Inhibitor	/	Unkown
HY-183488	R9-caPep		/	Unkown
HY-183581	USP1-IN-18	Inhibitor	/	Unkown
HY-184385	PI3K/AKT/JAK2-IN-1	Inhibitor	/	Unkown
HY-P10825	p21PBP	Inhibitor	/	Unkown
HY-RS10159	PCNA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-110111A	T2AA hydrochloride	Inhibitor	/	Unkown
HY-117846	MLAF50	Agonist	/	Unkown
HY-152051S	Mabuterol-d9 hydrochloride	Agonist	/	Unkown
HY-RS16672	Pcna Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23107	Pcna Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W755295	Mabuterol hydrochloride	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PCNA	VGNC	VGNC:81144
Bos taurus	PCNA	VGNC	VGNC:32635
Rattus norvegicus	PCNA	RGD	RGD:3269
Macaca mulatta	PCNA	VGNC	VGNC:97114
Mus musculus	PCNA	MGD	MGI:97503
Canis familiaris	PCNA	VGNC	VGNC:44310
Others	PCNA	NCBI