Art. -Nr.: HY-N0737

Harmine hydrochloride

(Synonyms: Telepathine hydrochloride)

29 Cited Publications

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Based on 29 publication(s) in Google Scholar

Harmine Hydrochloride (Telepathine Hydrochloride) is a natural DYRK inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT_2A serotonin receptor, with an K_i of 397 nM.

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Reinheit: 99.98%
CAS. Nr.: 343-27-1
Formel: C₁₃H₁₃ClN₂O
Molecular Weight:248.71

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Harmine hydrochloride Chemical Structure

CAS. Nr.: 343-27-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (29)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

5-HT_2A Receptor

397 nM (Ki)

DYRK1A

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen :

Alle DYRK Isoform-spezifische Produkte anzeigen :

In Vitro

Harmine inhibits tau phosphorylation by DYRK1A by selected DANDYs, with an IC₅₀ of 190 nM^[2]. Harmine negatively regulates homologous recombination (HR) by interfering Rad51 recruitment, resulting in severe cytotoxicity in hepatoma cells. Furthermore, NHEJ inhibitor Nu7441 markedly sensitizes Hep3B cells to the anti-proliferative effects of Harmine^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

It is shown that brain water content is significantly increased in the TBI group. Treatment with Harmine significantly reduces the tissue water content at 1, 3 and 5 days, compared with the TBI group. Harmine treatment significantly reduces the escape latency at 3 and 5 days, compared with the TBI group. Post-TBI administration of Harmine significantly improves the motor function recovery of the rats at 1, 3 and 5 days following TBI, compared with the TBI group without Harmine treatment. The neuronal survival rate in the Harmine-treated group is significantly increased, compared with the TBI group. Administration of Harmine results in marked elevation in the expression of GLT-1, compared with the TBI group. The administration of Harmine significantly reduces the expression of caspase 3, compared with the TBI group^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 343-27-1
Appearance Solid
Molecular Weight 248.71
Formel C₁₃H₁₃ClN₂O
Color Off-white to light yellow
SMILES

CC1=NC=CC2=C1NC3=C2C=CC(OC)=C3.Cl
Synonyms

Telepathine hydrochloride
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (29)

All WBCell Migration/Invasion AssayIn Vivo Efficacy StudyIF

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Journal Impact Factor

Cell Stem Cell

A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration. [Abstract]

2022 Apr 7;29(4):545-558.e13. PMID: 35395187
J Clin Invest

TWIST1+FAP+ fibroblasts in the pathogenesis of intestinal fibrosis in Crohn's disease. [Abstract]

2024 Jul 18:e179472. PMID: 39024569

Harmine hydrochloride purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2024 Jul 18:e179472. [Abstract]

Western blotting images showing the expression of ECM-related genes in primary human intestinal fibroblasts with or without TGF-β (5 ng/mL, 48 hours) and Harmine administration (5 μM or 10 μM, 48 hours).

Harmine hydrochloride purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2024 Jul 18:e179472. [Abstract]

Masson’s trichrome staining showing collagen deposition in mouse colons across the 4 indicated groups. Twist1^fl/fl mice and Col1a2-Cre^ERT2Twist1^fl/fl cohoused littermates (8 weeks old) were injected intraperitoneally with tamoxifen daily for 4 days (100 mg per kg body weight each time). The mice were subjected to 3 cycles of DSS administration (7 days of DSS administration followed by 14 days of regular drinking water). Harmine (10 mg/kg) was injected intraperitoneally twice a week during each DSS cycle (regularly on Tuesday and Friday weekly).

Harmine hydrochloride purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2024 Jul 18:e179472. [Abstract]

Representative IF staining of mouse colons across the 4 indicated groups (original magnification, ×20). DAPI (blue), COL1A1 (red), and vimentin (green) in merged channels are shown. Twist1^fl/fl mice and Col1a2-Cre^ERT2Twist1^fl/fl cohoused littermates (8 weeks old) were injected intraperitoneally with tamoxifen daily for 4 days (100 mg per kg body weight each time). The mice were subjected to 3 cycles of DSS administration (7 days of DSS administration followed by 14 days of regular drinking water). Harmine (10 mg/kg) was injected intraperitoneally twice a week during each DSS cycle (regularly on Tuesday and Friday weekly).
Sci Adv

Haploid-genetic screening of trophectoderm specification identifies Dyrk1a as a repressor of totipotent-like status. [Abstract]

2023 Dec 22;9(51):eadi5683. PMID: 38117886
J Biomed Sci

DYRK1A reinforces epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma via cooperatively activating STAT3 and SMAD. [Abstract]

2022 Jun 2;29(1):34. PMID: 35655269

Harmine hydrochloride purchased from MedChemExpress. Usage Cited in: J Biomed Sci. 2022 Jun 2;29(1):34. [Abstract]

HepG2 cells were incubated with Harmine (0, 2, 4, 8 μM) and were then cultured in the upper compartment of Transwell chambers for 24 h. Then, the cells were stained with crystal violet solution.

Harmine hydrochloride purchased from MedChemExpress. Usage Cited in: J Biomed Sci. 2022 Jun 2;29(1):34. [Abstract]

Following treatment with Harmine (0, 5, 10, 20 μM) for 24 h at the indicated concentrations, total protein was extracted from HEPG2 and Hep3B cells and analysed by western blotting.

Harmine hydrochloride purchased from MedChemExpress. Usage Cited in: J Biomed Sci. 2022 Jun 2;29(1):34. [Abstract]

HCC cells were serum-starved overnight, a scratch was created, and the cells were then incubated with 10 μM harmine and/or 10 ng/mL TGF-β for 6 h. Images were acquired under a microscope.

Harmine hydrochloride purchased from MedChemExpress. Usage Cited in: J Biomed Sci. 2022 Jun 2;29(1):34. [Abstract]

Cells were serum-starved overnight and were then treated with Harmine (10 μM) or 10 ng/mL TGF-β for 6 h. Western blot analysis was then performed.
Cancer Biol Med

DYRK1A suppression restrains Mcl-1 expression and sensitizes NSCLC cells to Bcl-2 inhibitors. [Abstract]

2020 May 15;17(2):387-400. PMID: 32587776
Phytomedicine

Genkwanin reduces airway epithelial cell ferroptosis and alleviates asthma symptoms in mice. [Abstract]

2025 Sep 24:148:157306. PMID: 41046685
Phytomedicine

Fangchinoline suppresses nasopharyngeal carcinoma progression by inhibiting SQLE to regulate the PI3K/AKT pathway dysregulation. [Abstract]

2025 May:140:156484. PMID: 40090046
Biochem Pharmacol

Harmine inhibits ovarian cancer migration and invasion and epithelial-mesenchymal transition (EMT) by inhibiting HDAC7 to restore RECK expression. [Abstract]

2025 Oct 7;242(Pt 4):117391. PMID: 41061932
J Ethnopharmacol

Qianyang Yuyin granules alleviate hypertension-induced vascular remodeling by inhibiting the phenotypic switch of vascular smooth muscle cells. [Abstract]

2025 Jan 30;337(Pt 3):118896. PMID: 39393558
Int J Oncol

DYRK1A suppression attenuates HIF‑1α accumulation and enhances the anti‑liver cancer effects of regorafenib and sorafenib under hypoxic conditions. [Abstract]

2022 Apr;60(4):45. PMID: 35244188
Int Immunopharmacol

Harmine attenuates renal fibrosis via Twist1 suppression: A novel anti-fibrotic strategy for chronic kidney disease with efficacy/safety profiling. [Abstract]

2026 Jan 1;168(Pt 2):115902. PMID: 41273846
Eur J Pharmacol

Harmine-induced disruption of the blood-brain barrier via excessive mitophagy in zebrafish. [Abstract]

2024 Dec 30:177223. PMID: 39742937
Eur J Pharmacol

MFN2-dependent mitochondrial dysfunction contributes to Relm-β-induced pulmonary arterial hypertension via USP18/Twist1/miR-214 pathway. [Abstract]

2024 Jul 31:980:176828. PMID: 39094924
Int Immunopharmacol

Harmine exerts anxiolytic effects by regulating neuroinflammation and neuronal plasticity in the basolateral amygdala. [Abstract]

2023 Jun:119:110208. PMID: 37150016
Front Cell Dev Biol

Harmine Alleviated Sepsis-Induced Cardiac Dysfunction by Modulating Macrophage Polarization via the STAT/MAPK/NF-κB Pathway. [Abstract]

2022 Jan 17;9:792257. PMID: 35111758
J Cell Mol Med

DYRK1A inhibition suppresses STAT3/EGFR/Met signalling and sensitizes EGFR wild-type NSCLC cells to AZD9291. [Abstract]

2019 Nov;23(11):7427-7437. PMID: 31454149
J Biol Chem

Harmine promotes axon regeneration through enhancing glucose metabolism. [Abstract]

2025 Feb 2:108254. PMID: 39904483
Sci Rep

The roles of autophagy, ferroptosis and pyroptosis in the anti-ovarian cancer mechanism of harmine and their crosstalk. [Abstract]

2024 Mar 18;14(1):6504. PMID: 38499622
Biomedicines

A Novel Druggable Dual-Specificity tYrosine-Regulated Kinase3/Calmodulin Kinase-like Vesicle-Associated Signaling Module with Therapeutic Implications in Neuroblastoma. [Abstract]

2024 Jan 16;12(1):197. PMID: 38255303
Prog Neuropsychopharmacol Biol Psychiatry

Harmine produces antidepressant-like effects via restoration of astrocytic functions. [Abstract]

2017 Jun 15;79(Pt B):258-267. PMID: 28625859

Harmine hydrochloride purchased from MedChemExpress. Usage Cited in: Prog Neuropsychopharmacol Biol Psychiatry. 2017 Jun 15;79(Pt B):258-267. [Abstract]

Representative images showing the restoration effect of Harmine on CUS-induced decrease in hippocampal DCX protein expressions. The Fluoxetine administration (20 mg/kg) is used as a positive control, and all data are shown as mean±SEM.
Sci Rep

Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ. [Abstract]

2015 Aug 3;5:12728. PMID: 26234946
BMC Infect Dis

Harmine acts as a quorum sensing inhibitor decreasing the virulence and antibiotic resistance of Pseudomonas aeruginosa. [Abstract]

2024 Jul 31;24(1):760. PMID: 39085766
Onco Targets Ther

Harmine suppresses the proliferation of pancreatic cancer cells and sensitizes pancreatic cancer to gemcitabine treatment. [Abstract]

2019 Jun 12:12:4585-4593. PMID: 31354292
J Integr Neurosci

Harmine-mediated Reduction of Bone Cancer Pain in Rats Correlates With Suppressed DYRK1A/NF-κB Signaling Axis. [Abstract]

2025 Jun 23;24(6):38100. PMID: 40613372
Exp Ther Med

Harmine reinforces the effects of regorafenib on suppressing cell proliferation and inducing apoptosis in liver cancer cells. [Abstract]

2022 Mar;23(3):209. PMID: 35126712
Res Sq

2025 Jul 08.
bioRxiv

2023 Dec 1.
SSRN

2023 Mar 8.
Research Square Preprint

2021 Aug.

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 10 mg/mL (40.21 mM; ultrasonic and warming and heat to 60°C)

DMSO : 5 mg/mL (20.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.0207 mL

20.1037 mL

40.2075 mL

5 mM

0.8041 mL

4.0207 mL

8.0415 mL

10 mM

0.4021 mL

2.0104 mL

4.0207 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (584 KB)
- English - EN (584 KB)
- Français - FR (584 KB)
- Deutsch - DE (584 KB)
- Norwegian - NO (584 KB)
- Español - ES (584 KB)
- Swedish - SV (584 KB)
- Italian - IT (584 KB)
- Portuguese - PT (584 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Glennon RA, et al. Binding of beta-carbolines and related agents at serotonin (5-HT(2) and 5-HT(1A)), dopamine (D(2)) and benzodiazepine receptors. Drug Alcohol Depend. 2000 Aug 1;60(2):121-32. [Content Brief]

[2]. Neumann F, et al. DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives. Sci Rep. 2018 Feb 12;8(1):2859. [Content Brief]

[3]. Zhang L, et al. Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells. Cancer Biol Ther. 2015;16(11):1585-92. [Content Brief]

[4]. Zhong Z, et al. Treatment with harmine ameliorates functional impairment and neuronal death following traumatic brain injury. Mol Med Rep. 2015 Dec;12(6):7985-91. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	4.0207 mL	20.1037 mL	40.2075 mL	100.5187 mL
	5 mM	0.8041 mL	4.0207 mL	8.0415 mL	20.1037 mL
	10 mM	0.4021 mL	2.0104 mL	4.0207 mL	10.0519 mL
	15 mM	0.2680 mL	1.3402 mL	2.6805 mL	6.7012 mL
	20 mM	0.2010 mL	1.0052 mL	2.0104 mL	5.0259 mL
H₂O	25 mM	0.1608 mL	0.8041 mL	1.6083 mL	4.0207 mL
	30 mM	0.1340 mL	0.6701 mL	1.3402 mL	3.3506 mL
	40 mM	0.1005 mL	0.5026 mL	1.0052 mL	2.5130 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Harmine hydrochloride

29 Cited Publications

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Harmine hydrochloride

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Publications Citing Use of MedChemExpress (MCE) Harmine hydrochloride

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen

Alle DYRK Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (29)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Harmine hydrochloride Related Classifications

Art. -Nr.: HY-N0737