HDAC-IN-32
Based on 1 publication(s) in Google Scholar
HDAC-IN-32 is a potent HDAC inhibitor with IC50s of 5.2, 11, and 28 nM for HDAC1, HDAC2 and HDAC6, respectively. HDAC-IN-32 possesses potent antiproliferation activities against tumor cells. HDAC-IN-32 shows potent antitumor efficacy in vivo That trigger antitumor immunity.
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- CAS. Nr.: 2766688-17-7
- Formel: C20H23N3O3
- Molecular Weight:353.41
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Publications Citing Use of MedChemExpress (MCE) HDAC-IN-32
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B16-F10 | IC50 |
4.8 μM
Compound: 9k
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Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
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[PMID: 35152694] |
| HEL | IC50 |
0.02 μM
Compound: 9k
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Antiproliferative activity against HEL cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against HEL cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
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[PMID: 35152694] |
| HepG2 | IC50 |
3.9 μM
Compound: 9k
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Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
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[PMID: 35152694] |
| K562 | IC50 |
0.29 μM
Compound: 9k
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Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
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[PMID: 35152694] |
| KG-1 | IC50 |
0.19 μM
Compound: 9k
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Antiproliferative activity against human KG-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human KG-1 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
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[PMID: 35152694] |
| PC-3 | IC50 |
2.7 μM
Compound: 9k
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Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
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[PMID: 35152694] |
HDAC-IN-32 (compound 9k) induces upregulation of Ac-HH3 and Ac-tubulin in tumor cells and induces apoptosis by cleavage of caspase-3. HDAC-IN-32 induces downregulation of SSRP1 and SPT16 and leads to chromatin damage. HDAC-IN-32 possesses better antimigration activities than SAHA and could reduce the expression level of MMP-2, which plays critical roles in tumor migration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2766688-17-7
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Molecular Weight 353.41
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Formel C20H23N3O3
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SMILES
O=C(NO)CCCCCCOC1=CC=CC(C2=NC3=CC=CC=C3N2)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
HDAC-IN-32 Related Classifications
HY-145687 Related Classifications
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