HDAC-IN-52
Based on 1 publication(s) in Google Scholar
HDAC-IN-52 is a pyridine-containing HDAC inhibitor, with IC50s of 0.189, 0.227, 0.440 and 0.446 μM for HDAC1, HDAC2, HDAC3, and HDAC10, respectively. HDAC-IN-52 can be used for the research of cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.46%
- CAS. Nr.: 2075787-77-6
- Formel: C24H20N4O2
- Molecular Weight:396.44
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) HDAC-IN-52
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
hHDAC1 0.189 μM (IC50) |
hHDAC2 0.227 μM (IC50) |
hHDAC3 0.440 μM (IC50) |
hHDAC10 0.446 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
1.28 μM
Compound: 8f; MC2664
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Antiproliferative activity against human A549 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human A549 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
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[PMID: 36549114] |
| HCT-116 | IC50 |
0.43 μM
Compound: 8f; MC2664
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Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
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[PMID: 36549114] |
| HL-60 | IC50 |
0.218 μM
Compound: 8f; MC2664
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Antiproliferative activity against human HL-60 cells incubated for 48 hrs
Antiproliferative activity against human HL-60 cells incubated for 48 hrs
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[PMID: 36549114] |
| K562 | IC50 |
0.37 μM
Compound: 8f; MC2664
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Antiproliferative activity against human K562 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
Antiproliferative activity against human K562 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
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[PMID: 36549114] |
| KARPAS-299 | IC50 |
9.27 μM
Compound: 8f; MC2664
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Antiproliferative activity against human KARPAS-299 cells incubated for 48 hrs
Antiproliferative activity against human KARPAS-299 cells incubated for 48 hrs
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[PMID: 36549114] |
| Kasumi 1 | IC50 |
0.257 μM
Compound: 8f; MC2664
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Antiproliferative activity against human Kasumi 1 cells incubated for 48 hrs
Antiproliferative activity against human Kasumi 1 cells incubated for 48 hrs
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[PMID: 36549114] |
| MV4-11 | IC50 |
0.17 μM
Compound: 8f; MC2664
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Antiproliferative activity against human MV4-11 cells incubated for 48 hrs
Antiproliferative activity against human MV4-11 cells incubated for 48 hrs
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[PMID: 36549114] |
| NB-4 | IC50 |
0.21 μM
Compound: 8f; MC2664
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Antiproliferative activity against human NB4 cells incubated for 48 hrs
Antiproliferative activity against human NB4 cells incubated for 48 hrs
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[PMID: 36549114] |
| OCI-AML2 | IC50 |
1.5 μM
Compound: 8f; MC2664
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Antiproliferative activity against human OCI-AML2 cells incubated for 48 hrs
Antiproliferative activity against human OCI-AML2 cells incubated for 48 hrs
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[PMID: 36549114] |
| OCI-AML-3 | IC50 |
4.14 μM
Compound: 8f; MC2664
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Antiproliferative activity against human OCI-AML-3 cells incubated for 48 hrs
Antiproliferative activity against human OCI-AML-3 cells incubated for 48 hrs
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[PMID: 36549114] |
| U-937 | IC50 |
0.822 μM
Compound: 8f; MC2664
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Antiproliferative activity against human U-937 cells incubated for 48 hrs
Antiproliferative activity against human U-937 cells incubated for 48 hrs
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[PMID: 36549114] |
In Vitro
HDAC-IN-52 (compound 8f) (72 hours) inhibits the proliferation of HCT116, A549 and K562 cells, with IC50s of 0.43, 1.28, and 0.37 μM, respectively[1].
HDAC-IN-52 (1-5 μM; 24-48 h) induces remarkable leukaemia U937 cell death after 48 h, with 76% and 100% pre-G1 phase arrest, respectively[1].
HDAC-IN-52 (1-5 μM; 48 h) increases mRNA expression of p21, BAX and BAK, downregulated cyclin D1 and BCL-2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2075787-77-6
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Appearance Solid
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Molecular Weight 396.44
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Formel C24H20N4O2
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Color Off-white to light yellow
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SMILES
NC1=CC=CC=C1NC(C2=NC=C(C=C2)NC(CC3=CC4=C(C=C3)C=CC=C4)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 16.67 mg/mL (42.05 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5224 mL | 12.6122 mL | 25.2245 mL | 63.0612 mL |
| 5 mM | 0.5045 mL | 2.5224 mL | 5.0449 mL | 12.6122 mL | |
| 10 mM | 0.2522 mL | 1.2612 mL | 2.5224 mL | 6.3061 mL | |
| 15 mM | 0.1682 mL | 0.8408 mL | 1.6816 mL | 4.2041 mL | |
| 20 mM | 0.1261 mL | 0.6306 mL | 1.2612 mL | 3.1531 mL | |
| 25 mM | 0.1009 mL | 0.5045 mL | 1.0090 mL | 2.5224 mL | |
| 30 mM | 0.0841 mL | 0.4204 mL | 0.8408 mL | 2.1020 mL | |
| 40 mM | 0.0631 mL | 0.3153 mL | 0.6306 mL | 1.5765 mL |
HDAC-IN-52 Related Classifications
HY-152174 Related Classifications
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