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Art. -Nr.: HY-182892

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MC4491

MC4491 is a selective LSD1/PRMT5 inhibitor, with an IC₅₀ of 0.152 μM against the LSD1/CoREST complex and an IC₅₀ of 0.043 μM against the PRMT5/MEP50 complex. MC4491 induces transcriptomic changes and splicing alterations in AML cells. MC4491 is applicable for the research of acute myeloid leukemia.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₃₅H₄₅N₇O₃
Molecular Weight:611.78

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

MC4491 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

LSD1

0.152 μM (IC₅₀)

PRMT5

0.043 μM (IC₅₀)

Alle Histone Demethylase Isoform-spezifische Produkte anzeigen :

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen :

In Vitro

MC4491 potently and selectively inhibits both LSD1/CoREST (IC₅₀ = 0.152 μM) and PRMT5/MEP50 (IC₅₀ = 0.043 nM) in biochemical assays, with minimal activity against PRMT1 and PRMT7^[1].
MC4491 (50 nM; 3 days) treatment of MV4-11 AML cells recapitulates the transcriptomic and alternative splicing changes induced by combined PRMT5 and LSD1 inhibition, including activation of myeloid differentiation pathways and suppression of cell cycle-related pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 611.78
Formel C₃₅H₄₅N₇O₃
SMILES

NC1CC1C2=CC=C(C=C2)NC(CCN3CCC(CC3)NC4=CC(C(NC[C@@H](CN5CCC6=CC=CC=C6C5)O)=O)=CC=N4)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Param NJ, et al. A synergistic interaction between PRMT5 and LSD1 inhibitors in AML. Sci Adv. 2026;12(13):eaea4059. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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MC4491

Alle Histone Demethylase Isoform-spezifische Produkte anzeigen

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

MC4491 Related Classifications

HY-182892 Related Classifications