Nanaomycin A
Based on 6 publication(s) in Google Scholar
Nanaomycin A is a selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A inhibits the in vitro growth of human Plasmodium falciparum with an IC80 of 33.1 nM.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.13%
- CAS. Nr.: 52934-83-5
- Formel: C16H14O6
- Molecular Weight:302.28
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Publications Citing Use of MedChemExpress (MCE) Nanaomycin A
MoreAlle DNA Methyltransferase Isoform-spezifische Produkte anzeigen
MoreAlle Parasite Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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DNMT3B 500 nM (IC50) |
Plasmodium |
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Cell Line
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Type | Value | Description | References |
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| Sf9 | IC50 |
0.5 μM
Compound: 23
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Inhibition of His6-tagged human recombinant DNMT3b expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biotinylated 45-bp unmethylated or hemimethylated oligonucleotide substrates and [3H]-AdoMet by liquid scinti
Inhibition of His6-tagged human recombinant DNMT3b expressed in insect Sf9 cells assessed as reduction in DNA methyltransferase activity using 5'-biotinylated 45-bp unmethylated or hemimethylated oligonucleotide substrates and [3H]-AdoMet by liquid scinti
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[PMID: 25406944] |
| Vero | CC50 |
0.7 μM
Compound: Nanaomycin A
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Cytotoxicity in African green monkey Vero cells assessed as reduction in cell viability
Cytotoxicity in African green monkey Vero cells assessed as reduction in cell viability
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[PMID: 32435413] |
Nanaomycin A (10-10000 nM; 72 hours) exhibited significant cytotoxicity in all three cell lines[1].
Nanaomycin A (0.5-5 μM; 72 hours) induced RASSF1A protein expression in A549 cells[1].
Nanaomycin A is a selective inhibitor of DNMT3B that induces genome demethylation and does not affect the enzyme activity of DNMT1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116 (colon), A549 (lung), and HL60 (bone marrow) human tumor cell lines
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Concentration:10, 100, 1000, 10000 nM
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Incubation Time:72 hours
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Result:Had a distinct cytotoxic effect in all three cell lines.
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Cell Line:A549 cells
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Concentration:0.5, 5 μM
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Incubation Time:72 hours
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Result:Revealed induction of RASSF1A protein expression.
Chemical Information
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CAS. Nr. 52934-83-5
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Appearance Solid
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Molecular Weight 302.28
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Formel C16H14O6
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Color Yellow to orange
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SMILES
O=C(O)C[C@H]1CC(C(C2=C3C(O)=CC=C2)=O)=C(C3=O)[C@H](C)O1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (6)
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Journal Impact Factor
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Most Recent
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Antioxid Redox Signal
Oxidative Stress-Induced Hypermethylation of KLF5 Promoter Mediated by DNMT3B Impairs Osteogenesis by Diminishing the Interaction with β-Catenin. [Abstract]2021 Jul;35(1):1-20. PMID: 33588625 -
Biochim Biophys Acta Mol Basis Dis
DNMT3B attenuates the development of thoracic aortic aneurysm and dissection by suppressing TFEB-mediated autophagy in vascular smooth muscle cells. [Abstract]2026 Jun 24;1872(7):168331. PMID: 42342163 -
Cancers (Basel)
DNMT3B Controls Enhancer-Linked Chromatin and Cell Cycle Networks in Acute Myeloid Leukemia. [Abstract]2026 Feb 24;18(5):723. PMID: 41827658 -
J Biol Chem
DNMT3b-mediated CpA methylation facilitates REST binding and gene silencing and exacerbates hippocampal demyelination in diabetic mice. [Abstract]2024 Dec 25:108137. PMID: 39730060 -
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Handling Instructions (2659 KB)
Verweise
[1]. Kuck D, et al.Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells.Mol Cancer Ther. 2010 Nov;9(11):3015-23. [Content Brief]
[2]. Tanaka Y, et al.Heme-dependent radical generation: possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicol.J Antibiot (Tokyo). 1999 Oct;52(10):880-8. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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