Paeoniflorin
Based on 41 publication(s) in Google Scholar
Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity.
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- Reinheit: 98.94%
- CAS. Nr.: 23180-57-6
- Formel: C23H28O11
- Molecular Weight:480.46
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Publications Citing Use of MedChemExpress (MCE) Paeoniflorin
More- Phytomedicine. 2026 Jul:156:158211. [Abstract]
- Phytomedicine. 2026 Jun:155:158111. [Abstract]
- Phytomedicine. 2025 Jul:142:156713. [Abstract]
- Phytomedicine. 2025 May:140:156573. [Abstract]
- Phytomedicine. 2025 May:140:156484. [Abstract]
- Free Radic Biol Med. 2025 Mar 28:S0891-5849(25)00193-5. [Abstract]
- Br J Pharmacol. 2026 Mar 5. [Abstract]
- Arch Pharm Res. 2026 Feb;49(2):242-261. [Abstract]
- PLoS Biol. 2024 Jun 27;22(6):e3002672. [Abstract]
- Phytother Res. 2022 Jun;36(6):2558-2571. [Abstract]
- J Agric Food Chem. 2026 Jan 28;74(3):2560-2573. [Abstract]
- Chin Med. 2025 Oct 2;20(1):153. [Abstract]
- J Ethnopharmacol. 2025 Nov 28:358:120957. [Abstract]
- J Ethnopharmacol. 2024 Jul 15:329:118140. [Abstract]
- J Ethnopharmacol. 2023 Jun 28:310:116422. [Abstract]
- Drug Des Devel Ther. 2024 Jun 20:18:2405-2420. [Abstract]
- Drug Des Devel Ther. 2021 Jan 22:15:245-257. [Abstract]
- CNS Neurosci Ther. 2023 Jun;29 Suppl 1(Suppl 1):161-184. [Abstract]
- Int J Mol Sci. 2025 Feb 11;26(4):1493. [Abstract]
- Pharmaceuticals (Basel). 2025 Aug 21;18(8):1241. [Abstract]
- Int Immunopharmacol. 2026 May 14:182:116841. [Abstract]
- Int Immunopharmacol. 2021 Dec;101(Pt B):108364. [Abstract]
- J Inflamm Res. 2025 Oct 7:18:13945-13964. [Abstract]
- J Photochem Photobiol B. 2025 May 28:269:113188. [Abstract]
- Heliyon. 2024 Jan 13;10(2):e24461. [Abstract]
- Food Chem Toxicol. 2025 May 13:115550. [Abstract]
- Naunyn Schmiedebergs Arch Pharmacol. 2026 Apr 23. [Abstract]
- Discov Oncol. 2024 Nov 15;15(1):659. [Abstract]
- Oral Dis. 2019 Nov;25(8):1945-1953. [Abstract]
- Immun Inflamm Dis. 2026 Jan;14(1):e70324. [Abstract]
- J Cosmet Dermatol. 2023 Oct;22(10):2824-2830. [Abstract]
- Chem Biodivers. 2022 Aug;19(8):e202200295. [Abstract]
- Dose Response. 2024 Oct 25;22(4):15593258241277919. [Abstract]
- Endocr J. 2024 Nov 1;71(11):1045-1053. [Abstract]
- Medicine. 2021 Jan 22;100(3):e23986. [Abstract]
- J Food Nutr Res. 2018, 6(1), 26-31.
- Res Sq. 2025 Oct 8.
- bioRxiv. 2024 Apr 3:2023.06.02.542933. [Abstract]
- Evid Based Complement Alternat Med. 2022 Oct 15:2022:1911311. [Abstract]
- Evid Based Complement Alternat Med. 2020 May 23;2020:8607931. [Abstract]
- Journal of the Korean Society of Food Science and Nutrition. 2017.9, 46(9):1091-1096.
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WB
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IF
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WB
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| N9 | IC50 |
27.8 μM
Compound: 12
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Antiinflammatory activity against mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 48 hrs by Griess reaction relative to control
Antiinflammatory activity against mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 48 hrs by Griess reaction relative to control
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[PMID: 19691309] |
| RAW264.7 | IC50 |
>100 μM
Compound: 10
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Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reaction
Inhibition of LPS-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reaction
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[PMID: 23067550] |
Paeoniflorin (80 μg/mL; 4-24 h) treatment can induce Hsp40 and Hsp27 as well as Hsp70[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa and IMR-32 cells
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Concentration:80 μg/mL
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Incubation Time:4, 8, 12, 16, and 24 hours
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Result:Promoted the phosphorylation of HSF1.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SD rats with collagen induced arthritis[4]
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Dosage:25 and 100mg/kg
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Administration:Intradermal injection; 25 and 100mg/kg; once daily; 20 days
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Result:Decreased arthritis score, relieved ankle and paw swelling, improved spleen istopathology, decreased the levels of IgA, IgM, IgG and anti-CII antibody.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 23180-57-6
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Appearance Solid
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Molecular Weight 480.46
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Formel C23H28O11
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Color White to off-white
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SMILES
O[C@H]1[C@H](O)[C@@H](O)[C@]([H])(O[C@]2([C@@]3(C)O[C@]4([H])O[C@@]5(C3)O)C[C@]5([H])[C@]24COC(C6=CC=CC=C6)=O)O[C@@H]1CO
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Synonyms
Peoniflorin
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (41)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Paeoniflorin modulates DL-glyceraldehyde metabolism to promote mitochondrial dynamics homeostasis and ameliorate knee osteoarthritis cartilage degeneration. [Abstract]2026 Jul:156:158211. PMID: 42068874 -
Phytomedicine
Paeoniflorin alleviates anxiety-like behaviors in sleep-deprived male mice by suppressing inflammation of the paraventricular nucleus of the hypothalamus. [Abstract]2026 Jun:155:158111. PMID: 41931995 -
Phytomedicine
Bioactive equivalent combinatorial components of Xiao-Xu-Ming decoction inhibit the calmodulin-mediated MLCK/MLC axis to attenuate coronary artery spasm. [Abstract]2025 Jul:142:156713. PMID: 40349422 -
Phytomedicine
Herbal-based Xuebijing injection ameliorated vascular endothelial dysfunction via inhibiting ACLY/MYB/RIG-I axis in sepsis-associated lung injury. [Abstract]2025 May:140:156573. PMID: 40088739 -
Phytomedicine
Fangchinoline suppresses nasopharyngeal carcinoma progression by inhibiting SQLE to regulate the PI3K/AKT pathway dysregulation. [Abstract]2025 May:140:156484. PMID: 40090046 -
Free Radic Biol Med
Paeoniflorin alleviated experimental Sjögren's syndrome by inhibiting NLRP3 inflammasome activation of submandibular gland cells via activating Nrf2/HO-1 pathway. [Abstract]2025 Mar 28:S0891-5849(25)00193-5. PMID: 40158745 -
Br J Pharmacol
Inhibition of GRK2 mitigates cisplatin-induced acute and chronic nephrotoxicity by targeting the NADPH oxidase 4/oxidative stress axis. [Abstract]2026 Mar 5. PMID: 41782455 -
Arch Pharm Res
PF protects retinal pigment epithelial cells from oxidative injury by enhancing mitophagy through a CUL3-dependent AMPK/ULK1 pathway. [Abstract]2026 Feb;49(2):242-261. PMID: 41622390 -
PLoS Biol
2024 Jun 27;22(6):e3002672. PMID: 38935621 -
Phytother Res
Paeoniflorin ameliorates lipopolysaccharide-induced acute liver injury by inhibiting oxidative stress and inflammation via SIRT1/FOXO1a/SOD2 signaling in rats. [Abstract]2022 Jun;36(6):2558-2571. PMID: 35570830 -
J Agric Food Chem
Peoniflorin Alleviates Corticotropin-Releasing Factor-Induced Irritable Bowel Syndrome by Improving the Intestinal Barrier Function through the Inhibition of the CRFR1/ROCK2/MLC Signaling Pathway. [Abstract]2026 Jan 28;74(3):2560-2573. PMID: 41550014 -
Chin Med
Integration of network pharmacology, transcriptomics and single-cell sequencing to explore the effect of Rougan Keli in alleviating liver cirrhosis. [Abstract]2025 Oct 2;20(1):153. PMID: 41039598 -
J Ethnopharmacol
Duhuo Jisheng decoction alleviates intervertebral disc degeneration by inhibiting nucleus pulposus cell pyroptosis via gallic acid-mediated downregulation of HIF-1α. [Abstract]2025 Nov 28:358:120957. PMID: 41317810 -
J Ethnopharmacol
Discovery and validation of anti-arthritic ingredients and mechanisms of Qingfu Juanbi Tang, a Chinese herbal formulation, on rheumatoid arthritis. [Abstract]2024 Jul 15:329:118140. PMID: 38565409 -
J Ethnopharmacol
Paeoniflorin protects against cisplatin-induced acute kidney injury through targeting Hsp90AA1-Akt protein-protein interaction. [Abstract]2023 Jun 28:310:116422. PMID: 36972781 -
Drug Des Devel Ther
Exploration of the Active Component and Mechanisms of Shengyu Decoction Against Myelosuppression Using Network Pharmacology and in vitro Experimental Validation. [Abstract]2024 Jun 20:18:2405-2420. PMID: 38915868 -
Drug Des Devel Ther
Paeoniflorin Sensitizes Breast Cancer Cells to Tamoxifen by Downregulating microRNA-15b via the FOXO1/CCND1/β-Catenin Axis. [Abstract]2021 Jan 22:15:245-257. PMID: 33519190 -
CNS Neurosci Ther
Tongqiao Huoxue Decoction ameliorates traumatic brain injury-induced gastrointestinal dysfunction by regulating CD36/15-LO/NR4A1 signaling, which fails when CD36 and CX3CR1 are deficient. [Abstract]2023 Jun;29 Suppl 1(Suppl 1):161-184. PMID: 37157929 -
Int J Mol Sci
Paeoniflorin Attenuates APAP-Induced Liver Injury via Intervening the Crosstalk Between Hepatocyte Pyroptosis and NETs. [Abstract]2025 Feb 11;26(4):1493. PMID: 40003959 -
Pharmaceuticals (Basel)
Network Pharmacology and Experimental Validation Identify Paeoniflorin as a Novel SRC-Targeted Therapy for Castration-Resistant Prostate Cancer. [Abstract]2025 Aug 21;18(8):1241. PMID: 40872629 -
Int Immunopharmacol
Albiflorin contributes to Xuebijing-mediated protection against sepsis-associated acute kidney injury by modulating the succinate-PFKFB3 immunometabolic axis. [Abstract]2026 May 14:182:116841. PMID: 42134292 -
Int Immunopharmacol
Paeoniflorin alleviates CFA-induced inflammatory pain by inhibiting TRPV1 and succinate/SUCNR1-HIF-1α/NLPR3 pathway. [Abstract]2021 Dec;101(Pt B):108364. PMID: 34844873 -
J Inflamm Res
Paeoniflorin Attenuates Cognitive Dysfunction and Neuroinflammation by Autophagy in Mice with SLE Induced by Imiquimod. [Abstract]2025 Oct 7:18:13945-13964. PMID: 41080153 -
J Photochem Photobiol B
Paeoniflorin protected UVA-exposed skin fibroblasts from caspase-3/GSDME mediated pyroptosis. [Abstract]2025 May 28:269:113188. PMID: 40466282 -
Heliyon
Paeoniflorin increases the anti-tumor efficacy of sorafenib in tumor-bearing mice with liver cancer via suppressing the NF-κb/PD-l1 axis. [Abstract]2024 Jan 13;10(2):e24461. PMID: 38312647 -
Food Chem Toxicol
Paeoniflorin attenuates cisplatin induced ototoxicity by inhibiting ferroptosis mediated by HMGB1/NRF2/GPX4 pathway. [Abstract]2025 May 13:115550. PMID: 40374000 -
Naunyn Schmiedebergs Arch Pharmacol
Paeoniflorin's role in inhibiting malignant metastasis of gastrointestinal stromal tumors via CYP3A4 modulation. [Abstract]2026 Apr 23. PMID: 42024238 -
Discov Oncol
Network pharmacology and in vitro experiments to investigate the anti-gastric cancer effects of paeoniflorin through the RAS/MAPK signaling pathway. [Abstract]2024 Nov 15;15(1):659. PMID: 39548020 -
Oral Dis
Anti-inflammatory effect of paeoniflorin combined with baicalin in oral inflammatory diseases. [Abstract]2019 Nov;25(8):1945-1953. PMID: 31393636
Paeoniflorin purchased from MedChemExpress. Usage Cited in: Oral Dis. 2019 Nov;25(8):1945-1953. [Abstract]
PF and BAI combination suppresses activation of the NF-κB signaling pathway in LPS-treated HOKs. Western blotting assay is performed to investigate expression of NF-κB inflammatory signaling proteins.
Paeoniflorin purchased from MedChemExpress. Usage Cited in: Oral Dis. 2019 Nov;25(8):1945-1953. [Abstract]
The nuclear translocation of NF-κB p65 was visualized using a laser confocal scanning microscope imaging system. Nuclei detected with DAPI (blue). Cells expressing NF-κB p65 in the cytoplasm (green). NF-κB p65 expresses mostly in the nucleus, and a small amount expressed in the cytoplasm (green). Localization of NF-κB p65 in the cytoplasm (green)
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Immun Inflamm Dis
Paeoniflorin Ameliorates Spinal Cord Injury by Controlling Apoptosis and Ferroptosis in H2O2-Damaged PC12 Cells. [Abstract]2026 Jan;14(1):e70324. PMID: 41560458 -
J Cosmet Dermatol
Paeoniflorin found in Paeonia lactiflora root extract inhibits melanogenesis by regulating melanin-related signal transduction in B16F10 cells. [Abstract]2023 Oct;22(10):2824-2830. PMID: 37288793 -
Chem Biodivers
Potential Chemoprevention of Paeoniflorin in Colitis-Associated Colorectal Cancer by Network Pharmacology, Molecular Docking, and In Vivo Experiment. [Abstract]2022 Aug;19(8):e202200295. PMID: 35841592 -
Dose Response
Paeoniflorin Inhibits Atrial Fibrosis and Atrial Fibrillation in Angiotensin II-Infused Mice Through the PI3K-Akt Pathway. [Abstract]2024 Oct 25;22(4):15593258241277919. PMID: 39469468 -
Endocr J
Paeoniflorin alleviates high glucose-induced endothelial cell apoptosis in diabetes mellitus by inhibiting HRAS-activated RAS pathway. [Abstract]2024 Nov 1;71(11):1045-1053. PMID: 39085078 -
Medicine
Paeoniflorin inhibits the macrophage-related rosacea-like inflammatory reaction through the suppressor of cytokine signaling 3-apoptosis signal-regulating kinase 1-p38 pathway. [Abstract]2021 Jan 22;100(3):e23986. PMID: 33545988 -
Paeoniflorin purchased from MedChemExpress. Usage Cited in: J Food Nutr Res. 2018, 6(1), 26-31.
LPS-induced RAW264.7 cells are pre-treated with the MCR extract (50 and 100 μg/mL), Paeoniflorin (10 and 30 μM), and Oxypaeoniflorin (10 and 30 μM) for 4 h and then co-treated with LPS (1 μg/ml) for 18 h. The expression of iNOS protein using western blot.
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bioRxiv
An efficient behavioral screening platform classifies natural products and other chemical cues according to their chemosensory valence in C. elegans. [Abstract]2024 Apr 3:2023.06.02.542933. PMID: 37333363 -
Evid Based Complement Alternat Med
Effects of Sensitized Sorafenib with a Paeoniflorin and Geniposide Mixture on Liver Cancer via the NF- κ B-HIF-2 α-SerpinB3 Pathway. [Abstract]2022 Oct 15:2022:1911311. PMID: 36285158 -
Evid Based Complement Alternat Med
Guizhi Fuling Capsule Exhibits Antidysmenorrhea Activity by Inhibition of Cyclooxygenase Activity. [Abstract]2020 May 23;2020:8607931. PMID: 32595743 -
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (208.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 100 mg/mL (208.13 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.20 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.20 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Reinheit & Dokumentation
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Data Sheet (285 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Yan-Xi Zhou, et al. A review on the pharmacokinetics of paeoniflorin and its anti-inflammatory and immunomodulatory effects. Biomed Pharmacother. 2020 Oct;130:110505. [Content Brief]
[2]. Yongjing Xiang, et al. Paeoniflorin: a monoterpene glycoside from plants of Paeoniaceae family with diverse anticancer activities. J Pharm Pharmacol. 2020 Apr;72(4):483-495. [Content Brief]
[3]. Dai Yan, et al. Paeoniflorin, a novel heat shock protein-inducing compound. Cell Stress Chaperones. 2004 Winter;9(4):378-89. Int J Oncol. 2013 Nov;43(5):1643-51. [Content Brief]
[4]. Pei-Pei Li, et al. BAFF/BAFF-R involved in antibodies production of rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin. J Ethnopharmacol. 2012 May 7;141(1):290-300. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.0813 mL | 10.4067 mL | 20.8134 mL | 52.0335 mL |
| 5 mM | 0.4163 mL | 2.0813 mL | 4.1627 mL | 10.4067 mL | |
| 10 mM | 0.2081 mL | 1.0407 mL | 2.0813 mL | 5.2033 mL | |
| 15 mM | 0.1388 mL | 0.6938 mL | 1.3876 mL | 3.4689 mL | |
| 20 mM | 0.1041 mL | 0.5203 mL | 1.0407 mL | 2.6017 mL | |
| 25 mM | 0.0833 mL | 0.4163 mL | 0.8325 mL | 2.0813 mL | |
| 30 mM | 0.0694 mL | 0.3469 mL | 0.6938 mL | 1.7344 mL | |
| 40 mM | 0.0520 mL | 0.2602 mL | 0.5203 mL | 1.3008 mL | |
| 50 mM | 0.0416 mL | 0.2081 mL | 0.4163 mL | 1.0407 mL | |
| 60 mM | 0.0347 mL | 0.1734 mL | 0.3469 mL | 0.8672 mL | |
| 80 mM | 0.0260 mL | 0.1301 mL | 0.2602 mL | 0.6504 mL | |
| 100 mM | 0.0208 mL | 0.1041 mL | 0.2081 mL | 0.5203 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.