PD128763
Based on 1 Customer Validation
PD128763 is a selective poly(ADP-ribose) polymerase inhibitor. PD128763 results in an enhancement of Streptozotocin (HY-13753)-induced cytotoxicity. PD128763 can be used in leukemia research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 129075-56-5
- Formel: C10H11NO
- Molecular Weight:161.20
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Speicherung:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
160 nM
Compound: 1
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Inhibition of PARP1 in human HeLa cells by fluid scintillation counting using [adenylated-32P]NAD as substrate
Inhibition of PARP1 in human HeLa cells by fluid scintillation counting using [adenylated-32P]NAD as substrate
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[PMID: 18713665] |
| L1210 | IC50 |
0.44 μM
Compound: 3
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Inhibition of the DNA repair Poly (ADP-ribose) polymerase 1, in permeabilised L1210 murine leukemia cells
Inhibition of the DNA repair Poly (ADP-ribose) polymerase 1, in permeabilised L1210 murine leukemia cells
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[PMID: 9857092] |
Chemical Information
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CAS. Nr. 129075-56-5
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Appearance Solid
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Molecular Weight 161.20
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Formel C10H11NO
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Color White to light yellow
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SMILES
O=C1NCCC=2C1=CC=CC2C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Sebolt-Leopold JS, et al. Enhancement of alkylating agent activity in vitro by PD 128763, a potent poly(ADP-ribose) synthetase inhibitor. Int J Radiat Oncol Biol Phys. 1992;22(3):619-21. [Content Brief]
[2]. Yau L, et al. Repression of phosphoenolpyruvate carboxykinase gene activity by insulin is blocked by 3-aminobenzamide but not by PD128763, a selective inhibitor of poly(ADP-ribose) polymerase. Eur J Biochem. 1998 Apr 1;253(1):91-100. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PD128763 Related Classifications
HY-W041672 Related Classifications
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