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Art. -Nr.: HY-160962

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SM1044

SM1044 is a dihydroartemisinin (DHA) dimer. SM1044 activates caspase, induces apooptosis in RL95-2 and KLE cells. SM1044 inhibits proliferations of cancer cells RL95-2, KLE, HEC-50, HEC-1-A, HEC-1-B, AN3CA, with IC₅₀ < 3.6 μM . SM1044 inhbits tumor growth in RL95-2 xenograft mouse model.

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CAS. Nr.: 1331880-08-0
Formel: C₃₄H₅₅NO₁₀
Molecular Weight:637.80

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SM1044 Chemical Structure

CAS. Nr.: 1331880-08-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Caspase Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
AN3-CA	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human AN3-CA cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human AN3-CA cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]
HEC-1-A	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human HEC-1-A cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HEC-1-A cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]
HEC-1B cell line	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human HEC-1B cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human HEC-1B cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]
KLE	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human KLE cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human KLE cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]
RL95-2	IC₅₀	1.16 μM Compound: SM1044	Antiproliferative activity against human RL95-2 cells assessed as inhibition of cell growth by MTT assay Antiproliferative activity against human RL95-2 cells assessed as inhibition of cell growth by MTT assay	[PMID: 36538859]

Chemical Information

CAS. Nr. 1331880-08-0
Molecular Weight 637.80
Formel C₃₄H₅₅NO₁₀
SMILES

C[C@@H]1[C@@]2([H])[C@]34[C@](O[C@](OO3)(CC[C@@]4([H])[C@@H](CC2)C)C)([H])O[C@@H]1OCCNCCO[C@@H]5[C@@H]([C@@]6([H])[C@]78[C@](O[C@](OO7)(CC[C@@]8([H])[C@@H](CC6)C)C)([H])O5)C
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhu Y, et al., Novel dihydroartemisinin dimer containing nitrogen atoms inhibits growth of endometrial cancer cells and may correlate with increasing intracellular peroxynitrite. Sci Rep. 2019 Oct 29;9(1):15528. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biologische Aktivität
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Chemical Information
Reinheit & Dokumentation
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SM1044

Alle Caspase Isoform-spezifische Produkte anzeigen