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Art. -Nr.: HY-162090

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TRPC antagonist 1

TRPC antagonist 1 (compound 15g) is a potent TRP channel (TRPC) antagonist with IC₅₀s of 2.4 μM, 12.2 μM, 7.6 μM, 2.9 μM, and 3.4 μM for TRPC3, TRPC4, TRPC5, TPRC6, and TRPC7, respectively. TRPC antagonist 1 displays noteworthy anti-glioblastoma efficacy in vitro against U87 cell lines.

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CAS. Nr.: 3027139-12-1
Formel: C₂₃H₂₂N₄O₂S
Molecular Weight:418.51

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

TRPC antagonist 1 Chemical Structure

CAS. Nr.: 3027139-12-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

TRPC3

2.4 μM (IC₅₀)

TRPC4

12.2 μM (IC₅₀)

TRPC5

7.6 μM (IC₅₀)

TRPC6

2.9 μM (IC₅₀)

TRPC7

3.4 μM (IC₅₀)

Alle TRP Channel Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	21.1 μM Compound: 15g	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 38185057]
HCT-116	IC₅₀	9.8 μM Compound: 15g	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 38185057]
LNCaP	IC₅₀	8.3 μM Compound: 15g	Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human LNCaP cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 38185057]
MKN-45	IC₅₀	11 μM Compound: 15g	Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 38185057]
U-87MG ATCC	IC₅₀	5.7 μM Compound: 15g	Antiproliferative activity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human U87 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 38185057]

Chemical Information

CAS. Nr. 3027139-12-1
Molecular Weight 418.51
Formel C₂₃H₂₂N₄O₂S
SMILES

NCCN(C1=NC(C(NC2=CC=C(O)C=C2)=O)=CS1)CC3=CC=C(C=CC=C4)C4=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Shanshan Wang, et al. Discovery of N-alkyl-N-benzyl thiazoles as novel TRPC antagonists for the treatment of glioblastoma multiforme. European Journal of Medicinal Chemistry. 22 December 2023, 116066.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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TRPC antagonist 1

Alle TRP Channel Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

TRPC antagonist 1 Related Classifications

HY-162090 Related Classifications