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3-TYP

105 Cited Publications
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Based on 105 publication(s) in Google Scholar

3-TYP is an inhibitor of SIRT3 (IC50of 38 μM) and an inhibitor of Methionine Adenosyltransferase (MAT) 2 and Indoleamine 2,3-Dioxygenase (IDO). There may be many off-target sites for 3-TYP that need to be examined, such as NAD-dependent enzymes, including dehydrogenases.

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  • Pureté: 99.90%
  • CAS No.: 120241-79-4
  • Formule: C7H6N4
  • Masse moléculaire:146.15
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • 3-TYP Chemical Structure
    3-TYP Chemical Structure
  • Experimental Validation Results for 3-TYP
  • Experimental Validation Results for 3-TYP
  • Experimental Validation Results for 3-TYP
  • Experimental Validation Results for 3-TYP
CAS No.: 120241-79-4
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  • 3-TYP Chemical Structure
    3-TYP Chemical Structure
    1/16
  • 1/16

    3-TYP purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2024 Aug 9:117066. [Abstract]

    Customer Validation
     WB images of SIRT3, AcK68-MnSOD and AcK122-MnSOD expressions in DRG tissues. Quantification of SIRT3, AcK68-MnSOD and AcK122-MnSOD expressions normalized with β-actin expressions and the Saline+Saline treated samples was set to 1 (NR (Nicotinamide riboside chloride); PTX (4 mg/kg, i. p.) Group, PTX (4 mg/kg, i.p.) + NR (400 mg/kg, i.g.) Group, PTX (4 mg/kg, I.P.) + NR (400 mg/kg, i.g.) +3-TYP (50 mg/kg, i.p.) group, NR (400 mg/kg, i.p.) group, 3-TYP (50 mg/kg, i.p.) group in SIRT3 WT mice)

  • 1/16

    3-TYP purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2024 Aug 9:117066. [Abstract]

    Customer Validation
     The representative images depicting the expression of AcK68-MnSOD in each group were utilized for immunohistochemical detection (NR (Nicotinamide riboside chloride); PTX (4 mg/kg, i. p.) Group, PTX (4 mg/kg, i.p.) + NR (400 mg/kg, i.g.) Group, PTX (4 mg/kg, I.P.) + NR (400 mg/kg, i.g.) +3-TYP (50 mg/kg, i.p.) group, NR(400 mg/kg, i.p.) group, 3-TYP (50 mg/kg, i.p.) group in SIRT3 WT mice)

  • 1/16

    3-TYP purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2023 Jan;24(1):162-173. [Abstract]

    Customer Validation
     A485 (10 μM; 24 h) leads to the downregulation of H3K9bhb and CPS1 in BHB-treated CD8+ TM cells; however, the use of 3-TYP (10 μM; 24 h) or Trichostatin A (TSA; 5 nM; 24 h) result in the increase of H3K9bhb and CPS1.

  • 1/16

    3-TYP purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2017;44(6):2212-2227. [Abstract]

    Customer Validation
     MEK, ERK1/2 and IκBα phosphorylation and their total protein expression are detected by Western blot. Cardiac myocytes are stimulated by Ang II for 48h after treatment with Sesamin (10 mM) or 3-TYP (50 μM).

  • 3-TYP