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Cat. No.: HY-P99459

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Biologically Validated

Baminercept

Name: Baminercept
Brand: MedChemExpress
SKU: HY-P99459
Price: 625.00 USD
Availability: InStock
Rating: 5 (3 reviews)

(Synonyms: BG 9924; TT-47)

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

Baminercept (BG 9924; TT-47) is an Ig fusion protein targeting the lymphotoxin β receptor (LTβR). Baminercept effectively regulates subsets of circulating immune cells by inhibiting LIGHT, LT-α1β2 and their receptors. Baminercept also increases blood lymphocyte counts and reduces plasma CXCL13 levels. Baminercept carries a high risk of hepatotoxicity. Baminercept can be used in research on rheumatoid arthritis and primary Sjögren's syndrome.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté : 99.97%
CAS No.: 909110-25-4
Masse moléculaire:93.76 kDa

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Baminercept Chemical Structure

CAS No.: 909110-25-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vivo
- Essai clinique
- Conjugated
- Reconsititution
- Format
- Application
- Verified Bioactivity
Chemical Information
Publications (3)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform TNF Receptor :

Voir tous les produits spécifiques à Isoform CXCR :

In Vivo

Baminercept (100 mg/kg) induces maternal liver toxicity in some pregnant rats, but shows no such effect in cynomolgus monkeys or non-pregnant rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

[LTBR (lymphotoxin beta receptor, TNFRSF3, tumor necrosis factor receptor superfamily (TNFR)member 3, TNFCR)]2-IGHG1 Fc (Fragment constant)

Application

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized TNF-beta/TNFSF1 Protein, Human (HY-P7304) can bind Baminercept. The EC₅₀ for this effect is 16.53 ng/mL.

Chemical Information

CAS No. 909110-25-4
Appearance Liquid
Masse moléculaire 93.76 kDa
Color Colorless to light yellow
SMILES

[Baminercept]
Synonyms

BG 9924; TT-47
Livraison

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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Journal Impact Factor

Nat Biotechnol

A tumor-on-a-chip for in vitro study of CAR-T cell immunotherapy in solid tumors. [Abstract]

2025 Oct 17. PMID: 41107533
bioRxiv

2026 Apr 30.
bioRxiv

2025 April 29.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (258 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Références

[1]. Bienkowska J, et al. Lymphotoxin-LIGHT pathway regulates the interferon signature in rheumatoid arthritis. PLoS One. 2014;9(11):e112545. Published 2014 Nov 18. [Content Brief]

[2]. St. Clair E W, et al. Clinical Efficacy and Safety of Baminercept, a Lymphotoxin β Receptor Fusion Protein, in Primary Sjögren's Syndrome: Results From a Phase II Randomized, Double‐Blind, Placebo‐Controlled Trial[J]. Arthritis & Rheumatology, 2018, 70(9): 1470-1480.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Baminercept

3 Cited Publications

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Activité biologique
- Description
- In Vivo
- Essai clinique
- Conjugated
- Reconsititution
- Format
- Application
- Biological Activity
Chemical Information
Publications (3)
Pureté et documentation
Références

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Quantité:
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Baminercept

Publications Citing Use of MedChemExpress (MCE) Baminercept

Voir tous les produits spécifiques à Isoform TNF Receptor

Voir tous les produits spécifiques à Isoform CXCR