Bisandrographolide A
Bisandrographolide A (BAA) activates TRPV4 channel with an EC50 of 790-950 nM. Bisandrographolide A can bind to CD81 and suppress its function. Bisandrographolide A is an anti-inflammatory, immunostimulant, and antihypertensive compound.
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- CAS No.: 160498-00-0
- Formule: C40H56O8
- Masse moléculaire:664.87
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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TRPV4 790-950 nM (IC50) |
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 160498-00-0
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Masse moléculaire 664.87
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Formule C40H56O8
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SMILES
O=C1C(C(C2C=C(/C=C/[C@H]3[C@@](CC[C@@H](O)[C@@]4(C)CO)(C)[C@]4([H])CCC3=C)C(O2)=O)C[C@H]5[C@@](CC[C@@H](O)[C@@]6(C)CO)(C)[C@]6([H])CCC5=C)=CCO1
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Synonyms
BAA
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Yue GG, et al. Identification of active components in Andrographis paniculata targeting on CD81 in esophageal cancer in vitro and in vivo. Phytomedicine. 2022 Jul 20;102:154183. [Content Brief]
[2]. Vriens J, et al. Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4. J Biol Chem. 2007 Apr 27;282(17):12796-803. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bisandrographolide A Related Classifications
HY-N2940 Related Classifications
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