Dimethothiazine
Dimethothiazine (Dimetotiazine; Fonazine) is an orally active tricyclic anti-histamine, anti-5-HT agent with a high activity against decerebrate rigidity, a little sedative activity and little soporific action. Dimethothiazine can reduce or abolish the effects of both static and dynamic fusimotor activity on the muscle spindle in decerebrate cat. Dimethothiazine can be used to research hemicrania and spasticity.
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- CAS No.: 7456-24-8
- Formule: C19H25N3O2S2
- Masse moléculaire:391.55
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Histamine, 5-HT[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Cats (decerebrate model; the carotid arteries were clamped and the mid-brain sectioned approximately between the colliculae)[2]
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Dosage:0.5, 1, 2, 4, 8 and 16 mg/kg
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Administration:i.v.; single dosage
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Result:Reduced the discharge frequency of primary and secondary endings at 1-4 mg/kg.
Reduced the sensitivity of the muscle spindle to stretch in preparations with intact ventral roots.
Reduced the activity of the dynamic fusimotor fibres.
Chemical Information
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CAS No. 7456-24-8
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Masse moléculaire 391.55
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Formule C19H25N3O2S2
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SMILES
O=S(C(C=C1N2CC(N(C)C)C)=CC=C1SC3=C2C=CC=C3)(N(C)C)=O
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Synonyms
Dimetotiazine; Fonazine
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Nattero G, et al. Use of dimethothiazine in the prevention of hemicrania. Minerva Med. 1977 Mar 17;68(13):839-45. [Content Brief]
[2]. Maxwell DR, Rhodes KF. The effects of dimethothiazine on muscle spindle activity in the decerebrate cat. Br J Pharmacol. 1970 Jul;39(3):520-32. [Content Brief]
[3]. Griffiths MI, et al. The use of dimethothiazine in the treatment of childhood cerebral palsy. Dev Med Child Neurol. 1973 Feb;15(1):25-32. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Dimethothiazine Related Classifications
HY-A0157 Related Classifications
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