CLK2 - CDC like kinase 2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1196

About CLK2

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,262,868-155,273,504 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 269 orthologues and 12 paralogues. Ubiquitous expression in spleen (RPKM 18.0), lymph node (RPKM 16.4) and 25 other tissues.

Summary

This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

CLK2 Products (4)

mRNA	Protein	Name
NM_001294338.2	NP_001281267.1	dual specificity protein kinase CLK2 isoform 1
NM_001294339.2	NP_001281268.1	dual specificity protein kinase CLK2 isoform 3
NM_001363704.2	NP_001350633.1	dual specificity protein kinase CLK2 isoform 4
NM_003993.4	NP_003984.2	dual specificity protein kinase CLK2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10480872	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	9637771	GOA
involved in regulation of RNA splicing	IDA IDA: Inferred from direct assay	9637771	GOA
involved in response to ionizing radiation	IMP IMP: Inferred from mutant phenotype	20682768	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in nucleus	IDA IDA: Inferred from direct assay	9637771	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLK2 Protein Structure

Pkinase

0
100
200
300
400
499 a.a.

Protein Preferred Names	Protein Names
dual specificity protein kinase CLK2	CLK kinase

CLK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	CLK2	P49760	FLJ13057	Homo sapiens	Q53SE7	Y2H Prey Pooling	25416956
Intra	CLK2	P49760	rnps1	Homo sapiens	D3DU92	Y2H Prey Pooling	25416956
Intra	CLK2	P49760	rnps1	Homo sapiens	D3DU92	Validated Y2H	25416956
Intra	CLK2	P49760	rnps1	Homo sapiens	D3DU92	Y2H Array	25416956
Intra	CLK2	P49760	U2AF1	Homo sapiens	Q01081-2	Y2H Array	25416956
Intra	CLK2	P49760	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	CLK2	P49760	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	CLK2	P49760	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	25416956
Intra	CLK2	P49760	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	LUZP4	Homo sapiens	Q9P127	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	LUZP4	Homo sapiens	Q9P127	Validated Y2H	32296183
Intra	CLK2	P49760	LUZP4	Homo sapiens	Q9P127	Y2H Array	32296183
Intra	CLK2	P49760	LUZP4	Homo sapiens	Q9P127	Y2H Prey Pooling	25416956
Intra	CLK2	P49760	ZNF394	Homo sapiens	Q53GI3	Validated Y2H	25416956
Intra	CLK2	P49760	ZNF394	Homo sapiens	Q53GI3	Y2H Array	25416956
Intra	CLK2	P49760	ZSCAN21	Homo sapiens	Q9Y5A6	Validated Y2H	32296183
Intra	CLK2	P49760	ZSCAN21	Homo sapiens	Q9Y5A6	Y2H Array	32296183
Intra	CLK2	P49760	ZSCAN21	Homo sapiens	Q9Y5A6	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	SNRNP70	Homo sapiens	P08621	Anti Tag CoIP	21988832
Intra	CLK2	P49760	SNRNP70	Homo sapiens	P08621	Y2H Array	32296183
Intra	CLK2	P49760	SNRNP70	Homo sapiens	P08621	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	SRRM1	Homo sapiens	Q8IYB3	Validated Y2H	25416956
Intra	CLK2	P49760	SRRM1	Homo sapiens	Q8IYB3	Y2H Array	25416956
Intra	CLK2	P49760	ZNF837	Homo sapiens	Q96EG3	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	ZNF837	Homo sapiens	Q96EG3	Y2H Array	32296183
Intra	CLK2	P49760	ZNF837	Homo sapiens	Q96EG3	Validated Y2H	32296183
Intra	CLK2	P49760	ZNF491	Homo sapiens	Q8N8L2	Validated Y2H	32296183
Intra	CLK2	P49760	ZNF491	Homo sapiens	Q8N8L2	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	ZNF491	Homo sapiens	Q8N8L2	Y2H Array	32296183
Intra	CLK2	P49760	ZNF317	Homo sapiens	Q96PQ6	Validated Y2H	32296183
Intra	CLK2	P49760	ZNF317	Homo sapiens	Q96PQ6	Y2H Array	32296183
Intra	CLK2	P49760	ZNF317	Homo sapiens	Q96PQ6	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	ZNF768	Homo sapiens	Q9H5H4	Y2H Array	32296183
Intra	CLK2	P49760	ZNF768	Homo sapiens	Q9H5H4	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	ZNF768	Homo sapiens	Q9H5H4	Validated Y2H	32296183
Intra	CLK2	P49760	PRM1	Homo sapiens	P04553	Y2H Array	32296183
Intra	CLK2	P49760	PRM1	Homo sapiens	P04553	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	ASPSCR1	Homo sapiens	Q9BZE9	Validated Y2H	32296183
Intra	CLK2	P49760	EHHADH	Homo sapiens	Q08426	Validated Y2H	32296183
Intra	CLK2	P49760	YTHDC1	Homo sapiens	Q96MU7	Y2H Prey Pooling	25416956
Intra	CLK2	P49760	YTHDC1	Homo sapiens	Q96MU7	Validated Y2H	25416956
Intra	CLK2	P49760	YTHDC1	Homo sapiens	Q96MU7	Validated Y2H	32296183
Intra	CLK2	P49760	YTHDC1	Homo sapiens	Q96MU7	Y2H Array	25416956
Intra	CLK2	P49760	YTHDC1	Homo sapiens	Q96MU7	Anti Tag CoIP	33961781
Intra	CLK2	P49760	ECE1	Homo sapiens	P42892	Y2H Array	25416956
Intra	CLK2	P49760	ECE1	Homo sapiens	P42892	Y2H Prey Pooling	25416956
Intra	CLK2	P49760	CACTIN	Homo sapiens	Q8WUQ7	Validated Y2H	32296183
Intra	CLK2	P49760	CACTIN	Homo sapiens	Q8WUQ7	Y2H Array	32296183
Intra	CLK2	P49760	CACTIN	Homo sapiens	Q8WUQ7	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	SRSF3	Homo sapiens	P84103	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	SRSF3	Homo sapiens	P84103	Validated Y2H	32296183
Intra	CLK2	P49760	SRSF3	Homo sapiens	P84103	Y2H Array	32296183
Intra	CLK2	P49760	RNF8	Homo sapiens	O76064	Y2H Array	32296183
Intra	CLK2	P49760	RNF8	Homo sapiens	O76064	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	ZNF558	Homo sapiens	Q96NG5	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	ZNF558	Homo sapiens	Q96NG5	Validated Y2H	32296183
Intra	CLK2	P49760	ZNF558	Homo sapiens	Q96NG5	Y2H Array	32296183
Intra	CLK2	P49760	RBM39	Homo sapiens	Q14498	TAP	23602568
Intra	CLK2	P49760	RBM39	Homo sapiens	Q14498	Y2H Prey Pooling	25416956
Intra	CLK2	P49760	RBM39	Homo sapiens	Q14498	Y2H Array	25416956
Intra	CLK2	P49760	RBM39	Homo sapiens	Q14498	Validated Y2H	32296183
Intra	CLK2	P49760	RNPS1	Homo sapiens	Q15287	Validated Y2H	32296183
Intra	CLK2	P49760	NXF1	Homo sapiens	Q9UBU9	Validated Y2H	32296183
Intra	CLK2	P49760	SRPK2	Homo sapiens	P78362	Y2H Array	25416956
Intra	CLK2	P49760	SRPK2	Homo sapiens	P78362	Y2H Prey Pooling	25416956
Intra	CLK2	P49760	GTPBP2	Homo sapiens	Q9BX10	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	GTPBP2	Homo sapiens	Q9BX10	Y2H Array	32296183
Intra	CLK2	P49760	GTPBP2	Homo sapiens	Q9BX10	Validated Y2H	32296183
Intra	CLK2	P49760	ZRSR2	Homo sapiens	Q15696	Validated Y2H	32296183
Intra	CLK2	P49760	ZRSR2	Homo sapiens	Q15696	Y2H Array	25416956
Intra	CLK2	P49760	PRPF38A	Homo sapiens	Q8NAV1	Y2H Prey Pooling	25416956
Intra	CLK2	P49760	PRPF38A	Homo sapiens	Q8NAV1	Validated Y2H	25416956
Intra	CLK2	P49760	TRIM27	Homo sapiens	P14373	Pull Down	32707033
Intra	CLK2	P49760	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	CLK2	P49760	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	CLK2	P49760	MRPL4	Homo sapiens	Q9BYD3	Y2H Prey Pooling	25416956
Intra	CLK2	P49760	MRPL4	Homo sapiens	Q9BYD3	Y2H Array	25416956
Intra	CLK2	P49760	ZNF440	Homo sapiens	Q8IYI8	Validated Y2H	32296183
Intra	CLK2	P49760	ZNF440	Homo sapiens	Q8IYI8	Y2H Array	32296183
Intra	CLK2	P49760	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	CLK2	P49760	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
Intra	CLK2	P49760	LNX1	Homo sapiens	Q8TBB1	Y2H Array	29892012
Intra	CLK2	P49760	LNX1	Homo sapiens	Q8TBB1	Y2H Array	31515488
Intra	CLK2	P49760	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	CLK2	P49760	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	CLK2	P49760	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	CLK2	P49760	ZNF263	Homo sapiens	O14978	Y2H Prey Pooling	25416956
Intra	CLK2	P49760	CLK3	Homo sapiens	P49761	Y2H Prey Pooling	25416956
Intra	CLK2	P49760	CLK3	Homo sapiens	P49761	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	CLK3	Homo sapiens	P49761	Anti Tag CoIP	33961781
Intra	CLK2	P49760	CLK3	Homo sapiens	P49761	Validated Y2H	32296183
Intra	CLK2	P49760	CLK3	Homo sapiens	P49761	Y2H Array	32296183
Intra	CLK2	P49760	CLK3	Homo sapiens	P49761	Y2H	21516116
Intra	CLK2	P49760	CLK3	Homo sapiens	P49761	Y2H Pooling	16189514
Intra	CLK2	P49760	RSRP1	Homo sapiens	Q9BUV0	Y2H Array	31515488
Intra	CLK2	P49760	RSRP1	Homo sapiens	Q9BUV0	Validated Y2H	25416956
Intra	CLK2	P49760	RSRP1	Homo sapiens	Q9BUV0	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	RSRP1	Homo sapiens	Q9BUV0	Validated Y2H	32296183
Intra	CLK2	P49760	RSRP1	Homo sapiens	Q9BUV0	Anti Tag CoIP	33961781
Intra	CLK2	P49760	RSRP1	Homo sapiens	Q9BUV0	Complementation	32296183
Intra	CLK2	P49760	RSRP1	Homo sapiens	Q9BUV0	Y2H Array	32296183
Intra	CLK2	P49760	ZNF764	Homo sapiens	Q96H86	Y2H Array	32296183
Intra	CLK2	P49760	ZNF764	Homo sapiens	Q96H86	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	ZNF764	Homo sapiens	Q96H86	Validated Y2H	32296183
Intra	CLK2	P49760	CPSF7	Homo sapiens	Q8N684	Y2H Prey Pooling	25416956
Intra	CLK2	P49760	CPSF7	Homo sapiens	Q8N684	Validated Y2H	25416956
Intra	CLK2	P49760	CPSF7	Homo sapiens	Q8N684	Y2H Array	25416956
Intra	CLK2	P49760	KLHL2	Homo sapiens	O95198	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	KLHL2	Homo sapiens	O95198	Y2H Array	25416956
Intra	CLK2	P49760	KLHL2	Homo sapiens	O95198	Y2H Array	32296183
Intra	CLK2	P49760	KLHL2	Homo sapiens	O95198	Validated Y2H	25416956
Intra	CLK2	P49760	ZNF136	Homo sapiens	P52737	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	ZNF136	Homo sapiens	P52737	Y2H Array	32296183
Intra	CLK2	P49760	ZNF136	Homo sapiens	P52737	Validated Y2H	32296183
Intra	CLK2	P49760	SNIP1	Homo sapiens	Q8TAD8	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	SNIP1	Homo sapiens	Q8TAD8	Validated Y2H	32296183
Intra	CLK2	P49760	SNIP1	Homo sapiens	Q8TAD8	Y2H Array	25416956
Intra	CLK2	P49760	SNIP1	Homo sapiens	Q8TAD8	Y2H Array	32296183
Intra	CLK2	P49760	SNIP1	Homo sapiens	Q8TAD8	Pull Down	32707033
Intra	CLK2	P49760	CLASRP	Homo sapiens	Q8N2M8	Validated Y2H	32296183
Intra	CLK2	P49760	CLASRP	Homo sapiens	Q8N2M8	Anti Tag CoIP	33961781
Intra	CLK2	P49760	CLASRP	Homo sapiens	Q8N2M8	Y2H Array	32296183
Intra	CLK2	P49760	CLASRP	Homo sapiens	Q8N2M8	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	ZNF473	Homo sapiens	Q8WTR7	Y2H Prey Pooling	25416956
Intra	CLK2	P49760	ZNF473	Homo sapiens	Q8WTR7	Y2H Array	25416956
Intra	CLK2	P49760	ZNF436	Homo sapiens	Q9C0F3	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	ZNF436	Homo sapiens	Q9C0F3	Validated Y2H	32296183
Intra	CLK2	P49760	ZNF436	Homo sapiens	Q9C0F3	Y2H Array	32296183
Intra	CLK2	P49760	ZNF398	Homo sapiens	Q8TD17	Validated Y2H	32296183
Intra	CLK2	P49760	ZNF398	Homo sapiens	Q8TD17	Validated Y2H	25416956
Intra	CLK2	P49760	ZNF398	Homo sapiens	Q8TD17	Y2H Prey Pooling	32296183
Intra	CLK2	P49760	ZNF398	Homo sapiens	Q8TD17	Y2H Array	32296183
Intra	CLK2	P49760	TRIM50	Homo sapiens	Q86XT4	Y2H Array	32296183
Intra	CLK2	P49760	TRIM50	Homo sapiens	Q86XT4	Validated Y2H	32296183
Intra	CLK2	P49760	TRIM50	Homo sapiens	Q86XT4	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

CLK2 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P810858	CLK2 Antibody	WB, IHC-P	Human, Monkey

Related Diseases

Diseases	Alias
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-137443	Ipivivint	Inhibitor	99.95%	Phase 1

Pre-clinical Phase

Bioactive Molecules (39)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-115470	CLK-IN-T3	Inhibitor	99.78%	Unkown
HY-147141	HS-276	Inhibitor	98.93%	Unkown
HY-144875	Rogocekib	Inhibitor	98.15%	Unkown
HY-112296	T025		99.64%	Unkown
HY-15951	ML167	Inhibitor	98.62%	Unkown
HY-108709	CC-671	Inhibitor	99.06%	Unkown
HY-155723	Leucettinib-92	Inhibitor	98.54%	Unkown
HY-153708	SGC-CLK-1	Inhibitor	99.12%	Unkown
HY-123600	SRI-29329	Inhibitor	99.14%	Unkown
HY-125290	MU1210	Inhibitor	99.50%	Unkown
HY-111379	EHT 5372	Inhibitor	98.12%	Unkown
HY-132175	CK2 inhibitor 2	Inhibitor	98.51%	Unkown
HY-149262	CLK1-IN-3		98.54%	Unkown
HY-122665	HTH-01-091	Inhibitor	99.81%	Unkown
HY-131978	DB18	Inhibitor	99.15%	Unkown
HY-113825	CLK1/2-IN-1	Inhibitor	99.87%	Unkown
HY-P10042A	S6K Substrate acetate	Substrate	98.19%	Unkown
HY-122665A	HTH-01-091 TFA	Inhibitor	99.48%	Unkown
HY-P10042	S6K Substrate	Substrate	/	Unkown
HY-113670	CLK1/2-IN-2	Inhibitor	99.31%	Unkown
HY-113831	CLK1/2-IN-3	Inhibitor	/	Unkown
HY-123853	CAM4066	Inhibitor	/	Unkown
HY-125201	Indazole 1	Inhibitor	/	Unkown
HY-125202	KuWal151	Inhibitor	/	Unkown
HY-147141A	HS-276 hydrochloride	Inhibitor	/	Unkown
HY-147141B	HS-276 formic	Inhibitor	/	Unkown
HY-157995	Dyrk1A-IN-7	Inhibitor	/	Unkown
HY-162398	LQ23	Inhibitor	/	Unkown
HY-168209	LBM22		/	Unkown
HY-173510	CLK2/3-IN-1	Inhibitor	/	Unkown
HY-176884	CDD-2110	Inhibitor	/	Unkown
HY-176885	CDD-2211	Inhibitor	/	Unkown
HY-176885A	CDD-2212	Inhibitor	/	Unkown
HY-182323	SGK1-IN-7	Inhibitor	/	Unkown
HY-183831	GPS167		/	Unkown
HY-RS02817	CLK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14360	TELO2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16769	Clk2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23209	Clk2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CLK2	VGNC	VGNC:27449
Rattus norvegicus	CLK2	RGD	RGD:1359711
Felis catus	CLK2	VGNC	VGNC:107859
Canis familiaris	CLK2	VGNC	VGNC:39347
Mus musculus	CLK2	MGD	MGI:1098669
Macaca mulatta	CLK2	VGNC	VGNC:71259
Others	CLK2	NCBI