Isoeucommin A
Isoeucommin A is a lignan compound. Isoeucommin A activates the Nrf2/HO-1 pathway and induces phosphorylation of GSK-3β. Isoeucommin A reduces the levels of pro-inflammatory cytokines TNF-α, IL-1β and IL-6, decreases the oxidative stress marker MDA, increases the antioxidants SOD and GSH, and alleviates oxidative stress in mesangial cells. Isoeucommin A alleviates renal tissue injury, improves impaired renal function and enhances the viability of renal tubular epithelial cells in diabetic nephropathy models. Isoeucommin A can be used in the research of diabetic nephropathy.
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- CAS No.: 134859-90-8
- Formule: C27H34O12
- Masse moléculaire:550.55
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Isoeucommin A (31.25-125 μM; 24 h) activates the Nrf2/HO-1 pathway in normal human renal mesangial cells (HRMCs)[1].
Isoeucommin A (61.3-125 μM; 24 h) activates the Nrf2/HO-1 pathway in high glucose (HG)-stimulated HRMCs by increasing p-GSK-3β levels[1].
Isoeucommin A (31.25-125 μM; 24 h) enhances the antioxidant capacity of HRMCs stimulated by high glucose (HG)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:normal human renal mesangial cells (HRMCs)
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Concentration:31.25 μM, 61.3 μM, 125 μM
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Incubation Time:24 h
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Result:Significantly increased Nrf2 protein expression at 31.25 μM.
Significantly increased both Nrf2 and HO-1 protein expression at 61.3 μM and 125 μM, with the highest concentration (125 μM) producing the greatest increase in protein levels.
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Cell Line:high-glucose (HG)-stimulated human renal mesangial cells (HRMCs)
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Concentration:61.3 μM, 125 μM
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Incubation Time:24 h
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Result:Significantly increased p-GSK-3β protein expression, the p-GSK-3β/GSK-3β ratio, Nrf2 protein expression, and HO-1 protein expression compared to the HG-only group, with 125 μM producing the most robust increases.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague Dawley (male, 8 weeks old, STZ-induced diabetic nephropathy)[1]
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Dosage:2.5 mg/kg; 5 mg/kg; 10 mg/kg
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Administration:i.v.; daily; 28 days
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Result:Reduced blood glucose and increased body weight gain significantly in the high-dose group compared to the DN model group.
Reduced kidney index, serum blood urea nitrogen, serum and urine creatinine, and urinary albumin-to-creatinine ratio significantly in medium- and high-dose groups compared to the DN model group.
Reduced serum TNF-α, IL-1β, IL-6, and kidney tissue MDA levels significantly, and increased kidney tissue SOD and GSH levels significantly in all dose groups compared to the DN model group, with effects increasing in a dose-dependent manner.
Reduced inflammatory cell infiltration, glomerular enlargement, renal tubular dilation, and renal tubular epithelial cell vacuolation in a dose-dependent manner, with the high-dose group nearing normal tissue morphology.
Increased renal Nrf2 and HO-1 mRNA and protein expression in a dose-dependent manner, with statistically significant elevations compared to the DN model group.
Chemical Information
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CAS No. 134859-90-8
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Masse moléculaire 550.55
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Formule C27H34O12
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SMILES
COC1=C(O)C(OC)=CC([C@@H]2[C@]3([H])[C@@](CO2)([H])[C@@H](C4=CC(OC)=C(C=C4)O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO)OC3)=C1
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Isoeucommin A Related Classifications
HY-N19615 Related Classifications
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