MC1742
Based on 1 publication(s) in Google Scholar
MC1742 is a potent HDAC inhibitor, with IC50s of 0.1 μM, 0.11 μM, 0.02 μM, 0.007 μM, 0.61 μM, 0.04 μM and 0.1 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10 and HDAC11, respectively. MC1742 can increase acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells growth. MC1742 can induce growth arrest, apoptosis, and differentiation in sarcoma CSC.
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- Pureté: 98.95%
- CAS No.: 1776116-74-5
- Formule: C21H21N3O3S
- Masse moléculaire:395.47
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Stockage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) MC1742
More
Activité biologique
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HDAC1 0.1 μM (IC50) |
HDAC2 0.11 μM (IC50) |
HDAC3 0.02 μM (IC50) |
HDAC6 0.007 μM (IC50) |
HDAC8 0.61 μM (IC50) |
HDAC10 0.04 μM (IC50) |
HDAC11 0.1 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| HFF | IC50 |
3295 nM
Compound: 1
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Cytotoxicity against HFF
Cytotoxicity against HFF
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[PMID: 30366254] |
MC1742 (compound 1) (0.5 and 2 μM; 24 hours) increases acetylation in a dose-dependent manner, observable as punctuate nuclear staining of acetyl-histone H3[1].
MC1742 (0.5, 1 and 2 μM; 24, 48 and 72 hours) significantly induces apoptosis of all CSC cultures[1].
MC1742 (0.025-0.5 μM; 14 days) enhances bone nodule formation in a significant dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Sarcoma cancer stem cells[1]
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Concentration:0.5 and 2 μM
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Incubation Time:24 hours
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Result:Increased acetylation in a dose-dependent manner, observable as punctuate nuclear staining of acetyl-histone H3.
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Cell Line:Sarcoma cancer stem cells[1]
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Concentration:0.5, 1 and 2 μM
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Incubation Time:24, 48 and 72 hours
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Result:Significantly induced apoptosis of all CSC cultures.
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Cell Line:Sarcoma cancer stem cells[1]
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Concentration:0.025, 0.05, 0.1 and 0.5 μM
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Incubation Time:14 days
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Result:Successfully enhanced bone nodule formation in a significant dose-dependent manner.
Chemical Information
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CAS No. 1776116-74-5
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Appearance Solid
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Masse moléculaire 395.47
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Formule C21H21N3O3S
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Color White to off-white
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SMILES
O=C1N=C(NC(C2=CC=C(C3=CC=CC=C3)C=C2)=C1)SCCCCC(NO)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
Solvant et solubilité
DMSO : 200 mg/mL (505.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5286 mL | 12.6432 mL | 25.2864 mL | 63.2159 mL |
| 5 mM | 0.5057 mL | 2.5286 mL | 5.0573 mL | 12.6432 mL | |
| 10 mM | 0.2529 mL | 1.2643 mL | 2.5286 mL | 6.3216 mL | |
| 15 mM | 0.1686 mL | 0.8429 mL | 1.6858 mL | 4.2144 mL | |
| 20 mM | 0.1264 mL | 0.6322 mL | 1.2643 mL | 3.1608 mL | |
| 25 mM | 0.1011 mL | 0.5057 mL | 1.0115 mL | 2.5286 mL | |
| 30 mM | 0.0843 mL | 0.4214 mL | 0.8429 mL | 2.1072 mL | |
| 40 mM | 0.0632 mL | 0.3161 mL | 0.6322 mL | 1.5804 mL | |
| 50 mM | 0.0506 mL | 0.2529 mL | 0.5057 mL | 1.2643 mL | |
| 60 mM | 0.0421 mL | 0.2107 mL | 0.4214 mL | 1.0536 mL | |
| 80 mM | 0.0316 mL | 0.1580 mL | 0.3161 mL | 0.7902 mL | |
| 100 mM | 0.0253 mL | 0.1264 mL | 0.2529 mL | 0.6322 mL |
MC1742 Related Classifications
HY-110280 Related Classifications
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